Atomic insights into the signaling landscape of E. coli PhoQ histidine kinase from molecular dynamics simulations. [PDF]
Sci RepBacteria rely on two-component systems to sense environmental cues and regulate gene expression for adaptation. The PhoQ/PhoP system exemplifies this crucial role, playing a key part in sensing magnesium (Mg2+) levels, antimicrobial peptides, mild acidic
Lazaridi S, Yuan J, Lemmin T.
europepmc +4 more sources
Interaction of vitamin D, homocystein and dental diseases
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020 The 1,2,4-triazole nucleus is resistant to metabolism and is an important pharmacophore; it can increase solubility and improve the pharmacokinetic and pharmacodynamic profile of drugs.
Ye. O. Karpun +3 more
doaj +1 more source
Mechanism of Regulation of Receptor Histidine Kinases [PDF]
Structure, 2012 Bacterial transmembrane receptors regulate an intracellular catalytic output in response to extracellular sensory input. To investigate the conformational changes that relay the regulatory signal, we have studied the HAMP domain, a ubiquitous intracellular module connecting input to output domains.
Ferris, Hedda U. +8 more
openaire +4 more sources
The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain [PDF]
, 2009 Michel K-P, Schröder A-K, Zimmermann M, et al. The hybrid histidine kinase Slr1759 of the cyanobacterium Synechocystis sp. PCC 6803 contains FAD at its PAS domain. Archives of Microbiology. 2009;191(6):553-559.The cyanobacterium Synechocystis sp.
Zimmermann, Maike +6 more
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FEBS Open Bio, 2014 Two-component signal transduction systems (TCS), consisting of a sensor histidine protein kinase and its cognate response regulator, are an important mode of environmental sensing in bacteria.
Alisha Dhiman +3 more
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The two-component sensor kinase TcsC and its role in stress resistance of the human-pathogenic mold Aspergillus fumigatus. [PDF]
, 2012 Two-component signaling systems are widespread in bacteria, but also found in fungi. In this study, we have characterized TcsC, the only Group III two-component sensor kinase of Aspergillus fumigatus. TcsC is required for growth under hyperosmotic stress,
Ilse D. Jacobsen (149635) +23 more
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Histidine-aspartate phosphotransfer architectures. [PDF]
, 2018 (A) A canonical two-component signaling system consists of a histidine kinase and a response regulator, wherein a signal is transmitted by transfer of a phosphoryl group from a conserved histidine in the HisKA domain (teal oval) to a conserved aspartate ...
N. Luisa Hiller (48998) +5 more
core +1 more source
Interaction Analysis of a Two-Component System Using Nanodiscs. [PDF]
PLoS ONE, 2016 Two-component systems are the major means by which bacteria couple adaptation to environmental changes. All utilize a phosphorylation cascade from a histidine kinase to a response regulator, and some also employ an accessory protein.
Patrick Hörnschemeyer +4 more
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Recent Advances in Histidine Kinase-Targeted Antimicrobial Agents
Frontiers in Chemistry, 2022 The prevalence of antimicrobial-resistant pathogens significantly limited the number of effective antibiotics available clinically, which urgently requires new drug targets to screen, design, and develop novel antibacterial drugs.
Hongtong Chen +11 more
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Xenopus NM23-X4 regulates retinal gliogenesis through interaction with p27Xic1 [PDF]
, 2009 Background. In Xenopus retinogenesis, p27Xic1, a Xenopus cyclin dependent kinase inhibitor, functions as a cell fate determinant in both gliogenesis and neurogenesis in a context dependent manner.
Toshiaki Mochizuki +18 more
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