Results 11 to 20 of about 87,659 (287)
Roles of Histidine Kinases and Histidine Phosphatases in Cancer
Chinese Journal of Lung Cancer, 2021 Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis ...
Yafang DONG +3 more
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Cell fate regulation governed by a repurposed bacterial histidine kinase. [PDF]
PLoS Biology, 2014 One of the simplest organisms to divide asymmetrically is the bacterium Caulobacter crescentus. The DivL pseudo-histidine kinase, positioned at one cell pole, regulates cell-fate by controlling the activation of the global transcription factor CtrA via ...
W Seth Childers +6 more
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Split histidine kinases enable ultrasensitivity and bistability in two-component signaling networks. [PDF]
PLoS Computational Biology, 2013 Bacteria sense and respond to their environment through signaling cascades generally referred to as two-component signaling networks. These networks comprise histidine kinases and their cognate response regulators.
Munia Amin +2 more
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Visualizing autophosphorylation in histidine kinases [PDF]
Nature Communications, 2014 Reversible protein phosphorylation is the most widespread regulatory mechanism in signal transduction. Autophosphorylation in a dimeric sensor histidine kinase is the first step in two-component signalling, the predominant signal-transduction device in bacteria.
Casino, Patricia +2 more
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Sequential conformational transitions and α-helical supercoiling regulate a sensor histidine kinase [PDF]
Nature Communications, 2017 Sensor histidine kinases (SHK) consist of sensor, linker and kinase modules and different models for SHK signal transduction have been proposed. Here the authors present nano- to millisecond time-resolved X-ray scattering measurements, which reveal a ...
Oskar Berntsson +19 more
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Histidine residue 94 is involved in pH sensing by histidine kinase ArsS of Helicobacter pylori. [PDF]
PLoS ONE, 2009 The ArsRS two-component system is the master regulator of acid adaptation in the human gastric pathogen Helicobacter pylori. Low pH is supposed to trigger the autophosphorylation of the histidine kinase ArsS and the subsequent transfer of the phosphoryl ...
Stefanie Müller +2 more
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A Transmembrane Histidine Kinase Functions as a pH Sensor [PDF]
Biomolecules, 2020 The two-component system DesK-DesR regulates the synthesis of unsaturated fatty acids in the soil bacteria Bacillus subtilis. This system is activated at low temperature and maintains membrane lipid fluidity upon temperature variations.
Ana Bortolotti +8 more
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Histidine Kinase Regulation by a Cyclophilin-like Inhibitor [PDF]
Journal of Molecular Biology, 2008 The sensor histidine kinase A (KinA) from Bacillus subtilis triggers a phosphorelay that activates sporulation. The antikinase KipI prevents sporulation by binding KinA and inhibiting the autophosphorylation reaction. Using neutron contrast variation, mutagenesis, and fluorescence data, we show that two KipI monomers bind via their C-domains at a ...
Jacques, DA +6 more
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Phytochrome: If It Looks and Smells Like a Histidine Kinase, Is It a Histidine Kinase? [PDF]
Cell, 1997 That's all fine and good for cyanobacterial phytochrome, but the real excitement has to do with potential functional homology of plant phytochromes. Specifically, do plant phytochromes possess histidine kinase activity and what then do we make of phytochrome-associated serine kinase activity? As discussed by Quail 1997xQuail, P.H. BioEssay.
Elich, Tedd D, Chory, Joanne
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Acid-Sensing Histidine Kinase With a Redox Switch
Frontiers in Microbiology, 2021 The EvgS/EvgA two-component signal transduction system in Escherichia coli is activated under mildly acidic pH conditions. Upon activation, this system induces the expression of a number of genes that confer acid resistance.
Shinya Inada +3 more
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