Roles of Histidine Kinases and Histidine Phosphatases in Cancer
Chinese Journal of Lung Cancer, 2021 Phosphorylation is the most common and important post-translational modification of proteins, which plays an important role in the regulation of cell proliferation, differentiation, development and metabolism, and is closely related to the tumorigenesis ...
Yafang DONG +3 more
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Determinants of Homodimerization Specificity in Histidine Kinases [PDF]
Journal of Molecular Biology, 2011 Two-component signal transduction pathways consisting of a histidine kinase and a response regulator are used by prokaryotes to respond to diverse environmental and intracellular stimuli.
Ashenberg, Orr +3 more
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A Transmembrane Histidine Kinase Functions as a pH Sensor [PDF]
Biomolecules, 2020 The two-component system DesK-DesR regulates the synthesis of unsaturated fatty acids in the soil bacteria Bacillus subtilis. This system is activated at low temperature and maintains membrane lipid fluidity upon temperature variations.
Ana Bortolotti +8 more
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Structural mechanism of signal transduction in a phytochrome histidine kinase [PDF]
Nature Communications, 2022 In this study, authors have solved cryo-EM structures of a bacteriophytochrome in its dark-adapted and illuminated states. The structures reveal the structural mechanism for photoactivation of the phytochrome.
Weixiao Yuan Wahlgren +7 more
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The sensor histidine kinase PhcS participates in the regulation of quorum sensing-dependent virulence genes in Ralstonia pseudosolanacearum strain OE1-1 [PDF]
Microbiology SpectrumRalstonia pseudosolanacearum strain OE1-1 secretes methyl 3-hydroxymyristate (3-OH MAME) as a quorum-sensing (QS) signal. Strain OE1-1 senses the chemical by the sensor histidine kinase PhcS, leading to the activation of the LysR family transcriptional ...
Wakana Senuma +7 more
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PKM2 functions as a histidine kinase to phosphorylate PGAM1 and increase glycolysis shunts in cancer [PDF]
The EMBO JournalPhosphoglycerate mutase 1 (PGAM1) is a key node enzyme that diverts the metabolic reactions from glycolysis into its shunts to support macromolecule biosynthesis for rapid and sustainable cell proliferation.
Yang Wang +18 more
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A Dual Regulatory Role of the PhoU Protein in Salmonella Typhimurium
mBio, 2022 Bacteria utilize two-component regulatory systems to sense and respond to their surroundings. Unlike other two-component systems that directly sense through a sensory domain in the histidine kinase (HK), the PhoB/PhoR two-component system requires ...
Soomin Choi +3 more
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Phytochrome: If It Looks and Smells Like a Histidine Kinase, Is It a Histidine Kinase? [PDF]
Cell, 1997 That's all fine and good for cyanobacterial phytochrome, but the real excitement has to do with potential functional homology of plant phytochromes. Specifically, do plant phytochromes possess histidine kinase activity and what then do we make of phytochrome-associated serine kinase activity? As discussed by Quail 1997xQuail, P.H. BioEssay.
Elich, Tedd D, Chory, Joanne
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Acid-Sensing Histidine Kinase With a Redox Switch
Frontiers in Microbiology, 2021 The EvgS/EvgA two-component signal transduction system in Escherichia coli is activated under mildly acidic pH conditions. Upon activation, this system induces the expression of a number of genes that confer acid resistance.
Shinya Inada +3 more
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Interaction of vitamin D, homocystein and dental diseases
Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2020 The 1,2,4-triazole nucleus is resistant to metabolism and is an important pharmacophore; it can increase solubility and improve the pharmacokinetic and pharmacodynamic profile of drugs.
Ye. O. Karpun +3 more
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