Healthy Aging Metabolomic and Proteomic Signatures Across Multiple Physiological Compartments
Aging Cell, EarlyView.The association of the aging scores with the clinical covariates suggests increased inflammation, strong predisposition to iron deficiency anemia, decline in muscle mass, and renal and hepatic functions with accelerated aging. ABSTRACT The study of biomarkers in biofluids and tissues expanded our understanding of the biological processes that drive ...
R. Moaddel +17 more
wiley +1 more source
A bacterial basic region leucine zipper histidine kinase regulating toluene degradation [PDF]
, 1997 Peter C. K. Lau +7 more
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Quantum walks and signal transduction pathways [PDF]
arXiv, 2012 Signal transduction pathways recover a crucial role in cellular processes: they represent a connection between environmental conditions and cellular reactions. There are many pathways and they all are related to create a network. But how can every protein find the right way more fast than possible? How can it find the right down-streaming kinase in the
arxiv
K2P channels and their protein partners. [PDF]
, 2005 A decade since their discovery, the K2P channels are recognized as pathways dedicated to regulated background leakage of potassium ions that serve to control neuronal excitability. The recent identification of protein partners that directly interact with
Goldstein, Steve AN +2 more
core +1 more source
Characterization of the genes encoding a receptor-like histidine kinase and a cognate response regulator from a biphenyl/polychlorobiphenyl-degrading bacterium, Rhodococcus sp. strain M5 [PDF]
, 1997 Diane Labbé +2 more
openalex +1 more source
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose The C‐type lectin‐like receptor‐2 (CLEC‐2) is a platelet receptor for the endogenous ligand podoplanin. This interaction contributes to several (patho)physiological processes, such as lymphangiogenesis, preservation of blood and lymphatic vessel integrity organ development, and tumour metastasis.
Marcin A. Sowa +8 more
wiley +1 more source
Crystal structure of a histidine kinase domain of the anaerobic sensor protein ArcB fromE. Coli [PDF]
, 1996 Toshio Hakoshima +4 more
openalex +1 more source
MD and EPR studies of the structure and dynamics of the MTSL spin-labelled activation loop of the Aurora-A kinase [PDF]
arXiv, 2015 The understanding of kinase structure is mostly based on protein crystallography, which is limited by the requirement to trap molecules within a crystal lattice. Therefore, characterisations of the conformational dynamics of the activation loop in solution are important to enhance the understanding of molecular processes related to diseases and to ...
arxiv
Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation
Biological Reviews, EarlyView.ABSTRACT Diatoms are a prominent microalgae family that has attracted interest for its production of molecules of biotechnological interest. Their fatty acid profile is rich in health‐beneficial omega‐3 eicosapentaenoic acid (EPA). Furthermore, under nutrient‐deprived conditions, many diatom species, notably Phaeodactylum tricornutum, Thalassiosira ...
Victor Murison +3 more
wiley +1 more source
A KaiC-Interacting Sensory Histidine Kinase, SasA, Necessary to Sustain Robust Circadian Oscillation in Cyanobacteria [PDF]
, 2000 Hideo Iwasaki +5 more
openalex +1 more source