Results 261 to 270 of about 135,178 (348)

The two-component system histidine kinase EnvZ contributes to Avian pathogenic Escherichia coli pathogenicity by regulating biofilm formation and stress responses. [PDF]

Poult Sci, 2023
Fu D, Wu J, Wu X, Shao Y, Song X, Tu J, Qi K.   +6 more
europepmc   +1 more source

Unlocking T‐Cell Plasticity in the Tumor Microenvironment: Implications for Cancer Progression and Therapeutic Strategies

MedComm – Oncology, Volume 4, Issue 2, June 2025.
The tumor microenvironment (TME) shapes T‐cell plasticity, influencing cancer progression and therapeutic outcomes. Here, we summarize the phenotypic transitions and spatial distribution of T cells within the TME, highlighting their dual roles in therapeutic efficacy and resistance.
Xiao‐Hong Ding, Xue‐Pei Li, Fenfang Chen, Han Wang, Yi‐Zhou Jiang   +4 more
wiley   +1 more source

Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ. [PDF]

Elife, 2021
Mensa B, Polizzi NF, Molnar KS, Natale AM, Lemmin T, DeGrado WF.   +5 more
europepmc   +1 more source

Phosphorylation of ITIM motifs drives the structural transition of indoleamine 2,3‐dioxygenase 1 between enzymatic and non‐enzymatic states

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Indoleamine 2,3‐dioxygenase 1 (IDO1) is the rate‐limiting enzyme in tryptophan metabolism that plays a central role in immune regulation across a range of diseases, including cancer. Beyond its enzymatic role, IDO1 has a non‐enzymatic function that remains poorly understood.
Gyula Hoffka, Lilla Hornyák, Lóránt Székvölgyi, Márton Miskei   +3 more
wiley   +1 more source

ADP reduces the oxygen-binding affinity of a sensory histidine kinase, FixL: The possibility of an enhanced reciprocating kinase reaction [PDF]

, 2004
Hiro Nakamura, Hideyuki Kumita, Kiyohiro Imai, Tetsutarō Iizuka, Yoshitsugu Shiro   +4 more
openalex   +1 more source

Identification, validation, and characterization of approved and investigational drugs interfering with the SARS‐CoV‐2 endoribonuclease Nsp15

Protein Science, Volume 34, Issue 6, June 2025.
Abstract Since the emergence of SARS‐CoV‐2 at the end of 2019, the virus has caused significant global health and economic disruptions. Despite the rapid development of antiviral vaccines and some approved treatments such as remdesivir and paxlovid, effective antiviral pharmacological treatments for COVID‐19 patients remain limited. This study explores
Spyros D. Chatziefthymiou, Maria Kuzikov, Sara Afandi, Greta Kovacs, Sukrit Srivastava, Andrea Zaliani, Andrey Gruzinov, Guillaume Pompidor, Michele Lunelli, Golam Rizvee Ahmed, Jörg Labahn, Johanna Hakanpää, Björn Windshügel, Michael Kolbe   +13 more
wiley   +1 more source

Targeting multidrug resistant Staphylococcus infections with bacterial histidine kinase inhibitors. [PDF]

Chem Sci, 2023
Espinasse A, Goswami M, Yang J, Vorasin O, Ji Y, Carlson EE.   +5 more
europepmc   +1 more source

Regulation of polyphenol oxidase activities and melanin synthesis in Marinomonas mediterranea: identification of ppoS, a gene encoding a sensor histidine kinase a aThe GenBank accession number for the sequence reported in this paper is AF398464.

, 2002
Patricia Lucas-Elı́o, Francisco Solano, Antonio Sánchez-Amat   +2 more
openalex   +1 more source

A putative multi-sensor hybrid histidine kinase, BarA _Ac , inhibits the expression of the type III secretion system regulator HrpG in Acidovorax citrulli. [PDF]

Front Microbiol, 2022
Qiao P, Zhao M, Guan W, Walcott R, Ye Y, Yang Y, Zhao T.   +6 more
europepmc   +1 more source

The Pseudoenzyme β‐Amylase9 From Arabidopsis Activates α‐Amylase3: A Possible Mechanism to Promote Stress‐Induced Starch Degradation

Proteins: Structure, Function, and Bioinformatics, Volume 93, Issue 6, Page 1189-1201, June 2025.
ABSTRACT Starch accumulation in plants provides carbon for nighttime use, for regrowth after periods of dormancy, and for times of stress. Both ɑ‐ and β‐amylases (AMYs and BAMs, respectively) catalyze starch hydrolysis, but their functional roles are unclear.
Christopher E. Berndsen, Amanda R. Storm, Angelina M. Sardelli, Sheikh R. Hossain, Kristen R. Clermont, Luke M. McFather, Mafe A. Connor, Jonathan D. Monroe   +7 more
wiley   +1 more source