Results 1 to 10 of about 18,587 (159)

Intermediate-dose cytarabine is an effective therapy for adults with non-Langerhans cell histiocytosis

Orphanet Journal of Rare Diseases, 2022
Background Non-Langerhans cell histiocytosis, including Erdheim–Chester disease (ECD), Rosai–Dorfman disease (RDD), indeterminate cell histiocytosis (ICH), and unclassified histiocytosis, is a rare disorder lacking a standard treatment strategy.
Ting Liu, Hua-cong Cai, Hao Cai, Miao Chen, Wei Zhang, Jian Li, Dao-bin Zhou, Xin-xin Cao   +7 more
doaj   +2 more sources

Histiocyte Society blueprint for non-Langerhans cell histiocytosis research: unraveling complex diseases through collaboration. [PDF]

Haematologica
Histiocytic neoplasms are rare hematologic disorders characterized by pathological infiltration of myeloid-derived cells in various organs, resulting in diverse manifestations.
Hershkovitz-Rokah O, Abeykoon JP, Ravindran A, Goyal G.   +3 more
europepmc   +2 more sources

Beyond Hepatitis: A Rare Case of Multisystem Langerhans Cell Histiocytosis in a Child. [PDF]

Clin Case Rep
ABSTRACT Langerhans cell histiocytosis (LCH) is a rare neoplastic disorder involving abnormal proliferation of dendritic cells, with clinical presentations ranging from isolated lesions to life‐threatening multisystem involvement. This case report describes a 26‐month‐old girl who presented with progressive jaundice, fever, hepatomegaly, pruritic scalp
Neupane D, Banjade RR, Joshi D, Awasthi PR, Mishra S.   +4 more
europepmc   +2 more sources

Successful Treatment of Non-Langerhans Cell Histiocytosis With Topical Rapamycin in Two Pediatric Cases

Clinical, Cosmetic and Investigational Dermatology, 2022
Raden Mohamad Rendy Ariezal Effendi, Trustia Rizqandaru, Renata Yuliasari, Srie Prihianti Gondokaryono, Inne Arline Diana, Reiva Farah Dwiyana Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran - Dr.
Effendi RMRA, Rizqandaru T, Yuliasari R, Gondokaryono SP, Diana IA, Dwiyana RF   +5 more
doaj   +2 more sources

The Clinicopathologic Spectrum of Rosai-Dorfman-Destombes Disease in Adults: An Analysis of 16 Cases. [PDF]

Eur J Haematol
ABSTRACT Rosai–Dorfman–Destombes disease (RDD) is a rare histiocytic proliferation with protean clinical manifestations, resulting from the accumulation of activated histiocytes within nodal and extra‐nodal tissues. The diagnosis can be missed, particularly when biopsies are obtained from extra‐nodal sites, where histological features may be less ...
Trinder M, Pryma C, Leung E, Slack GW, Farinha P, Young S, Ozkaya N, Carruthers M, Chen LYC.   +8 more
europepmc   +2 more sources

Tissue-Resident Myeloid and Histiocytic Cells in Health and Disease: Novel Emerging Concepts. [PDF]

Am J Hematol
ABSTRACT Although all myeloid cells are considered to derive from hematopoietic stem cells, the cells in each myeloid lineage are heterogeneous populations, and their distribution and functions vary, depending on underlying physiologic and pathologic processes, age, sex, and genetic and epigenetic signatures.
Valent P, Wojta J, Kovanen PT, Hermine O, Fend F, Sotlar K, Greinix H, Geissler K, Hartmann K, Schwaab J, Herling M, Boccuni L, Kazianka L, John MV, Sperr WR, Zierfuss C, Tzankov A, Sillaber C, Minkov M, Hoermann G, Collin M, Horny HP, Haferlach T, Sibilia M, Haroche J, La Rosée P, Orfao A, Arock M.   +27 more
europepmc   +2 more sources

A Rare Case of Erdheim-Chester Disease (Non-Langerhans Cell Histiocytosis) with Concurrent Langerhans Cell Histiocytosis: A Diagnostic and Therapeutic Challenge

Case Reports in Hematology, 2018
Erdheim-Chester disease (ECD) is a rare non-Langerhans cell histiocyte disorder most commonly characterized by multifocal osteosclerotic lesions of the long bones demonstrating sheets of foamy histiocyte infiltrates on biopsy with or without histiocytic ...
Hamza Hashmi, Drew Murray, John Greenwell, Marwan Shaikh, Soumit Basu, Maxwell Krem   +5 more
doaj   +2 more sources

Langerhans cell histiocytosis of the thyroid mimicking thyroiditis in a boy: a case report and literature review

BMC Pediatrics
Background Langerhans cell histiocytosis affecting the thyroid commonly presents with nonspecific clinical and radiological manifestations. Thyroid Langerhans cell histiocytosis is typically characterized by non-enhancing hypodense lesions with an ...
Yu Fan Cheng, Ching Che Wang, Pei Shan Tsai, Dao Chen Lin, Wen Hui Huang   +4 more
doaj   +2 more sources

Erdheim–Chester Disease Manifesting Without Long Bone Involvement [PDF]

Respirology Case Reports
Erdheim–Chester Disease (ECD) is an extremely rare, non‐Langerhans cell histiocytosis characterised by the proliferation of foamy histiocytes infiltrating various organs.
Dhiran Sivasubramanian, Karthick Balasubramanian, Mohamed Raghib Hussain Mohamed Kalifa, Sathwik Sanil, Smrti Aravind, Nithish Nanda Palanisamy, Virushnee Senthilkumar   +6 more
doaj   +2 more sources

Successful treatment of non-Langerhans cell histiocytosis with the MEK inhibitor trametinib: a multicenter analysis

Blood Advances, 2023
Key Points • MAPK alterations are a hallmark of ECD and RDD.• The MEK inhibitor trametinib is active in non-LCHs, including those without BRAF V600E mutations.
A. Aaroe, R. Kurzrock, G. Goyal, A. Goodman, H. Patel, G. Ruan, G. Ulaner, J. Young, Ziyi Li, D. Dustin, R. Go, E. Diamond, F. Janku   +12 more
semanticscholar   +1 more source