Results 11 to 20 of about 22,368 (237)

MEK Inhibition with Trametinib in Patients with Non-Langerhans Cell Histiocytosis

Blood, 2019
Background: Activation of the MAPK pathway through BRAF mutations or other molecular alterations is a hallmark of the non-Lagerhans cell histiocytosis (non-LCH) such Erdheim-Chester disease (ECD) or Rosai-Dorfman disease (RDD).
F. Janku, H. Patel, Vaijayanthi Raghavan, A. Goodman, T. Barnes, R. Kurzrock   +5 more
semanticscholar   +2 more sources

Langerhans Cell Histiocytosis Presenting With Diabetes Insipidus in a 2 Years Old Child: A Case Report. [PDF]

Clin Case Rep
ABSTRACT This case report highlights that Langerhans cell histiocytosis should be suspected in the differential diagnosis for children who exhibit failure to thrive, diabetes insipidus, and skin lesions. Early recognition and timely management are crucial for preventing irreversible hypothalamic–pituitary damage and improving outcomes.
Yohannes KG, Kassa NB, Tesso ZG, Digga AM.   +3 more
europepmc   +2 more sources

High prevalence of myeloid neoplasms in adults with non-Langerhans cell histiocytosis. [PDF]

Blood, 2017
Key Points Some 10.1% of adults with non–Langerhans cell histiocytosis have a concomitant myeloid neoplasm with each often harboring distinct mutations. The presence of distinct kinase mutations in histiocytosis and myeloid neoplasms resulted in discordant responses to targeted therapy.
M. Papo, E. Diamond, F. Cohen-Aubart, J. Emile, Damien Roos-Weil, N. Gupta, B. Durham, N. Ozkaya, A. Dogan, G. Ulaner, R. Rampal, J. Kahn, T. Sené, F. Charlotte, B. Hervier, C. Besnard, O. Bernard, C. Settegrana, N. Droin, Z. Hélias-Rodzewicz, Z. Amoura, O. Abdel-Wahab, J. Haroche   +22 more
semanticscholar   +4 more sources

Refractory Periorbital Necrobiotic Xanthogranuloma Treated With Plasma Cell-Directed Therapy. [PDF]

EJHaem
eJHaem, Volume 7, Issue 1, February 2026.
Trando A, Jeong AR, Goodman AM.
europepmc   +2 more sources

Clinical periodontal diagnosis

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases include pathological conditions elicited by the presence of bacterial biofilms leading to a host response. In the diagnostic process, clinical signs such as bleeding on probing, development of periodontal pockets and gingival recessions, furcation involvement and presence of radiographic bone loss should be assessed prior ...
Giovanni E. Salvi, Andrea Roccuzzo, Jean‐Claude Imber, Alexandra Stähli, Björn Klinge, Niklaus P. Lang   +5 more
wiley   +1 more source

Non-Langerhans cell histiocytosis in a child with Kawasaki disease

BMJ Case Reports, 2009
Polymorphous skin rashes are one of the major presentations in children with Kawasaki disease. This report describes an unusual presentation of a skin rash (non-Langerhans cell histiocytosis) in a 4-month-old baby with resistance to intravenous immunoglobulin (IVIG) treatment and coronary artery dilatation.
Ho‐Chang Kuo, Chih-Chiang Wu, Tsung-Hsien Yang, Hong-Ren Yu, C. Liang, Yi-Ju Chen, Kuender D Yang   +6 more
semanticscholar   +4 more sources

Case of Non-Langerhans Cell Histiocytosis in a Person Living with HIV - Clinical and Therapeutic Challenge

Journal of the International Association of Providers of AIDS Care, 2022
Non-Langerhans cell histiocytosis is a rare disease which seldom affects adults. We report a case of a 32-year-old Bulgarian woman living with HIV. She developed severe anemia, extreme splenomegaly, requiring splenectomy and vertebral tumor formations ...
Nina Yancheva, Dimitar Strashimirov, Dragomir Dardanov, Bojidar Kamenov, Atanas Radinoff   +4 more
doaj   +1 more source

Cutaneous Rosai-Dorfman Disease - A Rare Non-Langerhans Cell Histiocytosis

JK Science
Cutaneous Rosai-Dorfman disease is classified as non-Langerhans cell histiocytosis. It is a benign lymphoproliferative disorder involving only skin and subcutaneous tissue, which is rare and not well documented.
Afthab Jameela Wahab, S. Athilakshmi, Nivvedhetha S   +2 more
doaj   +1 more source

Langerhans-Cell Histiocytoses - Epidemiology, Classification, Clinical Features, Diagnosis, Complications, Treatment and Prognosis [PDF]

Journal of Biomedical & Clinical Research, 2016
Histiocytoses comprise a group of diverse diseases of unknown etiology with various clinical presentation and evolution. The underlying pathology is characterised by accumulation and infiltration of variable numbers of cells of the monocyte-macrophage ...
Vera Papochieva, Dimitrinka Miteva, Penka Perenovska, Guergana Petrova   +3 more
doaj   +3 more sources

Adult Langerhans cell histiocytosis with pulmonary and colorectoanal involvement: a case report

Journal of Medical Case Reports, 2017
Background Langerhans cell histiocytosis is a rare systemic disease characterized by the abnormal overproduction of histiocytes that tend to infiltrate single or multiple organ systems leading to significant tissue damage. It mainly affects – by order of
Mohamad Jihad Mansour, Elias Mokbel, Eddy Fares, Janah Maddah, Fadi Nasr   +4 more
doaj   +1 more source