Use of OKT3 with ciclosporin and steroids for reversal of acute kidney and liver allograft rejection [PDF]
, 1987 OKT3 monoclonal antibody therapy was added to preexisting baseline immunosuppressive treatment with ciclosporin and steroids to treat rejection in 52 recipients of cadaveric livers and 10 recipients of cadaveric kidneys.
Demetris, AJ, Fung, JJ, Porter, KA
core +1 more source
Functional immunomics: Microarray analysis of IgG autoantibody repertoires predicts the future response of NOD mice to an inducer of accelerated diabetes [PDF]
, 2004 One's present repertoire of antibodies encodes the history of one's past immunological experience. Can the present autoantibody repertoire be consulted to predict resistance or susceptibility to the future development of an autoimmune disease? Here we developed an antigen microarray chip and used bioinformatic analysis to study a model of type 1 ...
arxiv +1 more source
Mother-child histocompatibility and risk of rheumatoid arthritis and systemic lupus erythematosus among mothers. [PDF]
, 2020 The study objective was to test the hypothesis that having histocompatible children increases the risk of rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE), possibly by contributing to the persistence of fetal cells acquired during ...
Barcellos, Lisa F +16 more
core
A comparison of methods for purification and concentration of norovirus GII-4 capsid virus-like particles [PDF]
, 2010 Noroviruses (NoVs) are one of the leading causes of acute gastroenteritis worldwide. NoV GII-4 VP1 protein was expressed in a recombinant baculovirus system using Sf9 insect cells.
A Bertolotti-Ciarlet +25 more
core +2 more sources
Interaction between noroviruses and human histo-blood group antigens
Uirusu, 2007 Norovirus (NOV), a member of the family Caliciviridae, is a major cause of water and food-borne acute nonbacterial gastroenteritis, and forms many morphologically similar but antigenically diverse groups of viruses. The virus-like particles (VLPs) derived from the prototype strain of NoV, Norwalk virus (NV/68), bind to histo-blood group antigens (HBGAs)
Haruko Shirato-Horikoshi, Naokazu Takeda
openaire +4 more sources
Molecular tug of war reveals adaptive potential of an immune cell repertoire [PDF]
arXiv, 2022 The adaptive immune system constantly remodels its lymphocyte repertoire for better protection against future pathogens. Its ability to improve antigen recognition on the fly relies on somatic mutation and selective expansion of B lymphocytes expressing high-affinity antigen receptors.
arxiv
ABO histo-blood group might modulate predisposition to Crohn's disease and affect disease behavior [PDF]
, 2014 BACKGROUND AND AIMS: ABO encodes a glycosyltranferase which determines the major human histo-blood group. The FUT2 fucosyltransferase allows expression of ABO antigens on the gastrointestinal mucosa and in bodily secretions (secretor phenotype).
A. Cassinotti +14 more
core +1 more source
Matching with multiple criteria and its application to health disparities research [PDF]
arXiv, 2023 Matching is a popular nonparametric covariate adjustment strategy in empirical health services research. Matching helps construct two groups comparable in many baseline covariates but different in some key aspects under investigation. In health disparities research, it is desirable to understand the contributions of various modifiable factors, like ...
arxiv
Regulation of T cell expansion by antigen presentation dynamics [PDF]
PNAS 2019, 116 (13) 5914-5919, 2018 An essential feature of the adaptive immune system is the proliferation of antigen-specific lymphocytes during an immune reaction to form a large pool of effector cells. This proliferation must be regulated to ensure an effective response to infection while avoiding immunopathology.
arxiv +1 more source
Genetic Diversity and Histo-Blood Group Antigen Interactions of Rhesus Enteric Caliciviruses [PDF]
Journal of Virology, 2010 ABSTRACTRecently, we reported the discovery and characterization of Tulane virus (TV), a novel rhesus calicivirus (CV) (T. Farkas, K. Sestak, C. Wei, and X. Jiang, J. Virol.82:5408-5416, 2008). TV grows well in tissue culture, and it represents a new genus withinCaliciviridae, with the proposed name ofRecovirus. We also reported a high prevalence of CV
Robert W. Cross +7 more
openaire +3 more sources