Results 51 to 60 of about 13,189,508 (152)

Cytokine‐Mediated Responses Across Endplate Subregions in Intervertebral Disc Multi‐Tissue Explants

JOR SPINE, Volume 9, Issue 4, December 2026.
ABSTRACT Background The endplate (EP) is essential for maintaining intervertebral disc (IVD) homeostasis by regulating nutrient transport to the nucleus pulposus (NP). Structural or biochemical alterations in the EP can impair this function and contribute to disc degeneration and low back pain (LBP).
Ahmad Alminnawi, Pablo Tejero, Carla Geeroms, Liesbet Geris, Christine L. Le Maitre   +4 more
wiley   +1 more source

Attachment of Norovirus to Histo Blood Group Antigens: A Cooperative Multistep Process

, 2015
Human noroviruses recognize histo blood group antigens (HBGAs) as cellular attachment factors. Recently, it has been discovered that norovirus infection can be significantly enhanced by HBGA binding.
Mallagaray, A, Alvaro Mallagaray, Grant Hansman, Uetrecht, Charlotte, Lockhauserbaumer, J, Lockhauserbäumer, Julia, Julia Lockhauserbäumer, Uetrecht, C, Peters, Thomas, Mallagaray, Alvaro, Charlotte Uetrecht, Peters, T, Hansman, G, Hansman, Grant, Thomas Peters   +14 more
core   +1 more source

A post-translational modification of human Norovirus capsid protein attenuates glycan binding

Nature Communications, 2019
Attachment of human noroviruses to histo blood group antigens (HBGAs) is essential for infection. Here the authors report that an asparagine residue located near the HBGA-attachment site can convert into an iso-aspartate residue through spontaneous ...
Alvaro Mallagaray, Robert Creutznacher, Jasmin Dülfer, Philipp H. O. Mayer, Lena Lisbeth Grimm, Jose Maria Orduña, Esben Trabjerg, Thilo Stehle, Kasper D. Rand, Bärbel S. Blaum, Charlotte Uetrecht, Thomas Peters   +11 more
doaj   +1 more source

Low Levels of Natural Anti-α-N-Acetylgalactosamine (Tn) Antibodies Are Associated With COVID-19

Frontiers in Microbiology, 2021
Human serum contains large amounts of anti-carbohydrate antibodies, some of which may recognize epitopes on viral glycans. Here, we tested the hypothesis that such antibodies may confer protection against COVID-19 so that patients would be preferentially
Adrien Breiman, Adrien Breiman, Nathalie Ruvoën-Clouet, Nathalie Ruvoën-Clouet, Marie Deleers, Marie Deleers, Tiffany Beauvais, Tiffany Beauvais, Nicolas Jouand, Jézabel Rocher, Nicolai Bovin, Nathalie Labarrière, Hanane El Kenz, Hanane El Kenz, Jacques Le Pendu   +14 more
doaj   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

No association between histo-blood group antigens and susceptibility to clinical infections with genogroup II norovirus [PDF]

, 2008
Noroviruses (NoVs) are a leading cause of viral gastroenteritis in humans. In the present study, the association between NoV susceptibility and the ABO histo-blood group was studied during 2 outbreaks of acute gastroenteritis in military units in Israel ...
Ambar, Ruhama, Kayouf, Raid, Halperin, Tamar, Klement, Eyal, Koopmans, Marion, Sela, Tamar, Vennema, Harry, Bar-Gal, Gila Kahila, Tamar Sela, Marion Koopmans, Harry Vennema, Tamar Halperin, Eyal Klement, Ruhama Ambar, Gila Kahila Bar‐Gal, Raid Kayouf   +15 more
core   +1 more source

Mesothelin as Biomarker and Therapeutic Target for Immunotherapy in Cancer

MedComm, Volume 7, Issue 10, October 2026.
Mesothelin overexpression activate important pathways like nuclear factor k‐light‐chain‐enhancer of activated B cells (NF‐κB) and interleukin‐6 (IL‐6). This in turn causes numerous cancers, such as pancreatic and ovarian cancers. MSLN‐targeting immunotherapies, like monoclonal antibodies, have shown efficacy.
Manoj Kumar Gupta, Ramakrishna Vadde, Ganji Purnachandra Nagaraju   +2 more
wiley   +1 more source

ABO histo-blood group antigen expression on the graft endothelium long term after ABO-compatible, non-identical heart transplantation

, 2006
We recently reported a complete change in the endothelial ABO histo-blood group phenotype of a cardiac allograft long term after B to O mismatched transplantation.
Mohacsi, Paul J, Kappeler, Andreas, Carrel, Thierry P, Schaffner, Thomas, Koestner, Simon C, Kappeler A, Mohacsi PJ, Carrel, Thierry, Schaffner T, Mohacsi, Paul, Koestner SC, Carrel TP, Thierry P. Carrel, Andreas Kappeler, Simon C. Koestner, Thomas Schaffner, Paul J. Mohacsi   +16 more
core   +1 more source

Mechanisms underlying the protective effects of San‐Bai decoction against UV radiation on the skin

International Journal of Cosmetic Science, Volume 48, Issue 5, Page 1006-1017, October 2026.
Combining conventional differential expression analysis with differential network analysis offers a promising strategy to uncover the mechanistic basis of the holistic benefits provided by herbal blends. Our findings demonstrated that San‐Bai decoction modulates multiple pathways—not only those related to skin pigmentation, such as ET‐1 signalling, but
Rui Zhang, Hong Zhang, Chengming Zhang, Wencai Jiang, Luonan Chen, Yimei Tan, Ying Zou, Xuelan Gu   +7 more
wiley   +1 more source

Forssman expression on human erythrocytes: biochemical and genetic evidence of a new histo-blood group system

, 2013
In analogy with histo-blood group A antigen, Forssman (Fs) antigen terminates with alpha 3-N-acetylgalactosamine and can be used by pathogens as a host receptor in many mammals.
Teneberg, Susann,, Jorgensen, Rene, Svensson, Lola, Svensson, Lola,, AK, Hult, Stamps, Robert, Henry, Stephen M., Martin L. Olsson, Rydberg, Lennart, Stephen M. Henry, ML, Olsson, SM, Henry, Hult, Annika,, Rydberg, Lennart,, Storry, Jill,, Storry, Jill, René Jørgensen, Jonas Ångström, Hult, Annika, Susann Teneberg, Olsson, Martin L, Jørgensen, R, Teneberg, Susann, Annika K. Hult, Lennart Rydberg, Robert Stamps, Angstrom, Jonas, R, Stamps, Ångström, Jonas,, Olsson, Martin L,, Jill R. Storry, Lola Svensson, Lund University., JR, Storry   +33 more
core   +1 more source