Direct Blockade of the Norovirus Histo-Blood Group Antigen Binding Pocket by Nanobodies
Journal of Virology, 2023 Human noroviruses are highly contagious and a major problem in closed institutions, such as schools, hospitals, and cruise ships. Reducing norovirus infections is challenging on multiple levels and includes the frequent emergence of antigenic variants, which complicates designing effective, broadly reactive capsid therapeutics.
Gargi Kher +8 more
openaire +4 more sources
The effects of symmetry on the dynamics of antigenic variation [PDF]
J. Math. Biol. 66, 115-137 (2013), 2012 In the studies of dynamics of pathogens and their interactions with a host immune system, an important role is played by the structure of antigenic variants associated with a pathogen. Using the example of a model of antigenic variation in malaria, we show how many of the observed dynamical regimes can be explained in terms of the symmetry of ...
arxiv +1 more source
Norovirus–host interaction: Multi-selections by human histo-blood group antigens [PDF]
Trends in Microbiology, 2011 The discovery of human histo-blood group antigens (HBGAs) as receptors or ligands of noroviruses (NoVs) raises a question about the potential role of host factors in the evolution and diversity of NoVs. Recent structural analysis of selected strains in the two major genogroups of human NoVs (GI and GII) demonstrated highly conserved HBGA binding ...
Xi Jiang, Xi Jiang, Ming Tan
openaire +3 more sources
The possibility of positive selection for both F18(+) Escherichia coli and stress resistant pigs opens new perspectives for pig breeding [PDF]
, 2007 International ...
Coddens, Annelies +7 more
core +2 more sources
Immunofluorescent Examination of Biopsies from Long-Term Renal Allografts [PDF]
, 1970 Immunofluorescent examination of open renal biopsies revealed clear-cut glomerular localization of immunoglobulins not related clearly to the quality of donor-recipient histocompatibility in 19 of 34 renal allografts.
Busch +9 more
core +1 more source
Attachment of Norovirus to Histo Blood Group Antigens: A Cooperative Multistep Process
Angewandte Chemie, 2015 AbstractHuman noroviruses recognize histo blood group antigens (HBGAs) as cellular attachment factors. Recently, it has been discovered that norovirus infection can be significantly enhanced by HBGA binding. Yet the attachment process and how it promotes host‐cell entry is only poorly understood.
Mallagaray, A +4 more
openaire +5 more sources
Absence of Neu5Gc and Presence of Anti-Neu5Gc Antibodies in Humans-An Evolutionary Perspective. [PDF]
, 2019 The glycocalyx of human cells differs from that of many other mammals by the lack of the sialic acid N-glycolylneuraminic acid (Neu5Gc) and increased abundance of its precursor N-acetylneuraminic acid (Neu5Ac).
Altman, Meghan O, Gagneux, Pascal
core +1 more source
The Hidden Conformation of Human Histo-blood Group Antigen is a Determinant for Recognition by Pathogen Lectins [PDF]
, 2016 International audienceHisto-blood group epitopes are fucosylated branched oligosaccharides with well-defined conformations in solution that are recognized by receptors, such as lectins from pathogens.
Arnaud, Julie +6 more
core +2 more sources
Expression of the gene encoding secretor type galactoside 2 ? fucosyltransferase (FUT2) and ABH antigens in patients with oral lesions [PDF]
, 2011 Objective: The aim of this work was to evaluate the expression of FUT2 gene in saliva and histo ABH antigens of patients with oral lesions. Study Design: In total 178 subjects were examined, half of whom suffered from oral pre-cancerous and cancerous ...
Biondi, Claudia +6 more
core +1 more source
Antibodies against Lewis antigens inhibit the binding of human norovirus GII.4 virus-like particles to saliva but not to intestinal Caco-2 cells. [PDF]
, 2016 BACKGROUND: Human noroviruses (NoVs) are the main cause of gastroenteritis worldwide. The most commonly detected NoV strains belong to the genetically diverse GII.4 genotype, with new pandemic variants emerging periodically.
Allen, David J +4 more
core +2 more sources