Results 51 to 60 of about 249,812 (201)
Histo-blood group antigens as mediators of infections [PDF]
Current Opinion in Structural Biology, 2017 The critical first step of a microbial infection is usually the attachment of pathogens to host cell glycans. Targets on host tissues are in particular the histo-blood group antigens (HBGAs), which are present in rich diversity in the mucus layer and on the underlying mucosa.
Heggelund, Julie E. +3 more
openaire +5 more sources
Lewis b antigen is a common ligand for genogroup I norovirus strains
FEBS Open Bio, 2022 Noroviruses are major causative agents of nonbacterial acute gastroenteritis in humans. Ten genogroups of noroviruses have been identified to date, among which genogroup I (GI) and genogroup II (GII) noroviruses are major pathogens for humans. GI and GII
Yuichi Someya
doaj +1 more source
Mathematical Modeling Insights into Improving CAR T cell Therapy for Solid Tumors: Antigen Heterogeneity and Bystander Effects [PDF]
npj Systems Biology and Applications, 10(1), 105 (2024), 2023 As an adoptive cellular therapy, Chimeric Antigen Receptor T-cell (CAR T-cell) therapy has shown remarkable success in hematological malignancies, but only limited efficacy against solid tumors. Compared with blood cancers, solid tumors present a unique set of challenges that ultimately neutralize the function of CAR T-cells.
arxiv +1 more source
Frontiers in Chemistry, 2021 The tandem-repeat Galectin-4 (Gal-4) contains two different domains covalently linked through a short flexible peptide. Both domains have been shown to bind preferentially to A and B histo blood group antigens with different affinities, although the ...
Jon I. Quintana +11 more
doaj +1 more source
Modulating expression of LAMPs and ABH histo-blood group antigens in normal and neoplastic human skin [PDF]
Open Medicine, 2006 Sarafian Victoria +2 more
doaj +2 more sources
Human Vaccines & Immunotherapeutics, 2021 Rotaviruses (RVs) are the leading cause of acute gastroenteritis in children, while histo-blood group antigens (HBGAs) are believed to be host attachment and susceptibility factors of RVs.
Jin-Xia Wang +14 more
doaj +1 more source
Expression of histo-blood group antigens in bronchial squamous metaplasia [PDF]
European Respiratory Journal, 2006 The aim of the present study was to evaluate the expression of blood group antigens in squamous bronchial metaplasia in order to determine whether this factor could identify patients at risk of lung cancer.In total, 100 bronchial biopsies were included in the present study.
M. Herranz Aladro +4 more
openaire +3 more sources
Frontiers in Microbiology, 2023 The FUT2 α1,2fucosyltransferase contributes to the synthesis of fucosylated glycans used as attachment factors by several pathogens, including noroviruses and rotaviruses, that can induce life-threatening gastroenteritis in young children.
Emmanuelle Godefroy +13 more
doaj +1 more source
A spoonful of sugar helps the viruses go down
Journal of Pediatric and Neonatal Individualized Medicine, 2022 Studies that attempt to deepen how pathogens try to circumvent the immune system and stimulate understanding of the mechanisms, can boost our knowledge on the process of viral infection, immune response circumvention and disease development.
Ruggiero Francavilla
doaj +1 more source
BMC Public Health, 2023 Background Histo-blood group antigens (HBGAs) which include the ABO and Lewis antigen systems have been known for determining predisposition to infections. For instance, blood group O individuals have a higher risk of severe illness due to V.
Caroline C. Chisenga +9 more
doaj +1 more source