Results 81 to 90 of about 13,139 (185)

Identification of Histone Deacetylase Inhibitor Targeting Type I Interferon and B Cell Abnormalities in Systemic Lupus Erythematosus

Arthritis &Rheumatology, Volume 78, Issue 4, Page 880-895, April 2026.
Objective Systemic lupus erythematosus (SLE) is characterized by increased Type I interferon (IFN‐I) and autoantibody production. This study aimed to identify drugs that can inhibit both IFN‐I and autoantibody production. Methods We identified an inhibitor of IFN‐I production from a chemical library.
Takehiro Hirayama, Hachiro Konaka, Yasuhiro Kato, Takayuki Shibahara, Chisato Nishizawa, Kohei Tsujimoto, JeongHoon Park, Eri Itotagawa, Tatsunori Jo, Masayuki Nishide, Sumiyuki Nishida, Yoshihito Shima, Masashi Narazaki, Wataru Aoki, Ken J Ishii, Hyota Takamatsu, Atsushi Kumanogoh   +16 more
wiley   +1 more source

Carbohydrate-carbohydrate interaction provides adhesion force and specificity for cellular recognition and adhesion [PDF]

, 2004
Carbohydrates at the cell surface have been proposed as mediators in cell-cell recognition events involved in embryogenesis, metastasis, and other proliferation processes by calcium-dependent carbohydrate to carbohydrate interactions.
Bucior, Iwona
core   +1 more source

Knockout of Low‐Density Lipoprotein Receptor‐Related Protein 1 From Astrocytes in Adult Mice Accelerates Long‐Term Functional Recovery After Ischemic Stroke

Brain and Behavior, Volume 16, Issue 4, April 2026.
We find that loss of LRP1 in astrocytes improves long‐term outcomes after ischemic stroke and is associated with reduced gliosis. Our findings suggest a role for LRP1 in astrocyte reactivity and response to stroke. ABSTRACT Purpose Ischemic stroke is a primary cause of death and disability worldwide; however, therapeutic opportunities are limited ...
Meng Wang, Sadiya N. Ahmad, Pamela Reed, Shane Sprague, Naomi L. Sayre   +4 more
wiley   +1 more source

Forssman expression on human erythrocytes: biochemical and genetic evidence of a new histo-blood group system

, 2013
In analogy with histo-blood group A antigen, Forssman (Fs) antigen terminates with alpha 3-N-acetylgalactosamine and can be used by pathogens as a host receptor in many mammals.
Teneberg, Susann,, Jorgensen, Rene, Svensson, Lola, Svensson, Lola,, AK, Hult, Stamps, Robert, Henry, Stephen M., Martin L. Olsson, Rydberg, Lennart, Stephen M. Henry, ML, Olsson, SM, Henry, Hult, Annika,, Rydberg, Lennart,, Storry, Jill,, Storry, Jill, René Jørgensen, Jonas Ångström, Hult, Annika, Susann Teneberg, Olsson, Martin L, Jørgensen, R, Teneberg, Susann, Annika K. Hult, Lennart Rydberg, Robert Stamps, Angstrom, Jonas, R, Stamps, Ångström, Jonas,, Olsson, Martin L,, Jill R. Storry, Lola Svensson, Lund University., JR, Storry   +33 more
core   +1 more source

Plasmodium falciparum antigens on the surface of the gametocyte-infected erythrocyte. [PDF]

, 2008
BACKGROUND: The asexual blood stages of the human malaria parasite Plasmodium falciparum produce highly immunogenic polymorphic antigens that are expressed on the surface of the host cell.
Christopher J. Drakeley, Saeed Maha, Saeed, Maha, Alexander Neal, Saeed, M., Geoffrey A T Targett, Sutherland, Colin J, Drakeley Christopher J., Targett Geoffrey A. T., Roeffen Will, Geoffrey A. T. Targett, Colin J. Sutherland, Targett, Geoffrey AT, Alexander, N., Neal Alexander, Colin J Sutherland, Sutherland Colin J., Targett, G.A.T., Roeffen, W.F.G., Roeffen, Will, Maha Saeed, Alexander, Neal, Drakeley, Christopher J, Drakeley, C., Will Roeffen, Christopher J Drakeley, Sutherland, C.J.   +26 more
core   +1 more source

Sequence‐Based and Functional Analysis for the Discovery of N‐Glycan Degrading Glycosidases From the Microbial Metagenome of the Infant Gut

MicrobiologyOpen, Volume 15, Issue 2, April 2026.
This research offers valuable understanding of how N‐glycans are broken down by the gut microbiota of infants, focusing on glycoside hydrolase families GH2, GH20, and GH18. It reveals that the gut microbiota of breastfed infants has a diverse array of genes coding for these enzymes.
Irene Boscá‐Sánchez, Jesús Rodríguez‐Díaz, María J. Yebra   +2 more
wiley   +1 more source

Histo-blood group antigens and rotavirus vaccine virus shedding in Australian infants

, 2023
Rotavirus vaccine performance varies between high and low income countries. One possible explanation is inherited histo-blood group antigens (HBGAs) the expression of which differs between populations.
D M Whiley (13307013), C Cheung (9858590), Peter Sly (13095165), Claire Y. T. Wang (10581691), Robert Ware (12793483), A El-Heneidy (13307007), K Grimwood (10975860), S B Lambert (13307010)   +7 more
core  

Chronic cerebral hypoperfusion exacerbates amyloid and tau pathology by impairing glymphatic transport via AQP4‐ and VEGF‐mediated pathways: insights from a vascular to mixed‐type dementia model

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Chronic cerebral hypoperfusion (CCH) is a major contributor to cognitive impairment; however, its underlying mechanisms remain poorly understood. METHODS We investigated CCH‐induced glymphatic dysfunction and neurodegeneration in amyloid precursor protein (APP)/presenilin 1 (PS1) and wild‐type mice.
Jia‐Hung Chen, Ching‐Wen Chang, You‐Yin Chen, Chih‐Hao Yang, Wen‐Bin Yang, Yi‐Chen Hsieh, Yao‐Wen Liang, Ssu‐Ju Li, Chaur‐Jong Hu   +8 more
wiley   +1 more source

Histo-Blood Group Antigen-Producing Bacterial Cocktail Reduces Rotavirus A, B, and C Infection and Disease in Gnotobiotic Piglets

Viruses
The suboptimal performance of rotavirus (RV) vaccines in developing countries and in animals necessitates further research on the development of novel therapeutics and control strategies.
Sergei A. Raev, Maryssa K. Kick, Maria Chellis, Joshua O. Amimo, Linda J. Saif, Anastasia N. Vlasova   +5 more
doaj   +1 more source

Norovirus–host interaction: Multi-selections by human histo-blood group antigens [PDF]

Trends in Microbiology, 2011
The discovery of human histo-blood group antigens (HBGAs) as receptors or ligands of noroviruses (NoVs) raises a question about the potential role of host factors in the evolution and diversity of NoVs. Recent structural analysis of selected strains in the two major genogroups of human NoVs (GI and GII) demonstrated highly conserved HBGA binding ...
Ming, Tan, Xi, Jiang
openaire   +2 more sources