Results 111 to 120 of about 211,384 (368)

Engineering the Immune Response to Biomaterials

Advanced Science, EarlyView.
This paper reviews immune responses to biomaterials, stages of evolution in relation to managing these responses ranging from preventing to modulating them. It also discusses state‐of‐the‐art strategies to modulate these responses and modes of their delivery.
Abolfazl Salehi Moghaddam, Mehran Bahrami, Einollah Sarikhani, Rumeysa Tutar, Yavuz Nuri Ertas, Faleh Tamimi, Ali Hedayatnia, Clotilde Jugie, Houman Savoji, Asma Talib Qureshi, Muhammad Rizwan, Chima V. Maduka, Nureddin Ashammakhi   +12 more
wiley   +1 more source

BOOST: A fast approach to detecting gene-gene interactions in genome-wide case-control studies [PDF]

arXiv, 2010
Gene-gene interactions have long been recognized to be fundamentally important to understand genetic causes of complex disease traits. At present, identifying gene-gene interactions from genome-wide case-control studies is computationally and methodologically challenging.
arxiv  

A Versatile High‐Throughput Single‐Cell Screening Platform for Profiling Antigen‐Specific Long‐Lived B Cells in Blood and Bone Marrow

Advanced Science, EarlyView.
The MoSMAR‐chip platform provides a high‐throughput and cost‐effective tool for identifying and characterizing antigen‐specific antibody‐secreting cells (ASCs) and memory B cells (MBCs) at the single‐cell level. The ASCs from coronavirus disease 2019 (COVID‐19) vaccine‐immunized mice were successfully analyzed, revealing diverse neutralizing antibodies
Tian Zhao, Yuqing Lei, Chang Liu, Dong Zhang, Kaiyi Li, Sisi Shan, Chenyu Li, Zimeng Wei, Yuhan Yang, Ting Zhang, Kai Sun, Haoran Sun, Linqi Zhang, Peng Liu   +13 more
wiley   +1 more source

Combining of Oncolytic Virotherapy and Other Immunotherapeutic Approaches in Cancer: A Powerful Functionalization Tactic

Global Challenges, Volume 7, Issue 1, January 2023., 2023
Combining oncolytic viruses with anti‐checkpoint antibodies such as anti‐PD‐1, anti‐PDL‐1, and anti‐CTLA4 or CAR‐T cells can be effective in cancer therapy in a synergistic fashion. Oncolytic virotherapy induces the expression of PD‐1 and PDL‐1 in the tumor microenvironment components. Virotherapy promotes the infiltration of CD4+ and CD8+ T cells into
Hai Zou, Xiao‐Zhou Mou, Biao Zhu
wiley   +1 more source

Genetic homogeneity between two populations of the parthenogenetic lizard Aspidoscelis cozumela Homogeneidad genética entre dos poblaciones de la lagartija partenogenética Aspidoscelis cozumela

Revista Mexicana de Biodiversidad, 2008
We used skin-grafting to assess the genetic variability between 2 populations of the parthenogenetic lizard Aspidoscelis cozumela. We transplanted 238 skin fragments among individuals of 2 coastal populations at Cozumel Island.
Norma L. Manríquez-Morán, Fausto R. Méndez-de la Cruz   +1 more
doaj  

The Transfer of Allergic Thyroiditis in Histocompatible Guinea Pigs by Lymph Node Cells [PDF]

, 1967
Philip R. B. McMaster, Edwin M. Lerner
openalex   +1 more source

Transcriptome Landscape of Cancer‐Associated Fibroblasts in Human PDAC

Advanced Science, EarlyView.
AP‐1 family members FOS and JUN regulate the malignant phenotype conversion of normal fibroblasts (NFs) to normal‐like cancer‐associated fibroblasts (nCAFs), while transforming growth factor‐β (TGFβ) and interferon‐γ (IFNγ) signals triggers the interconversion between classic myofibroblastic CAFs (myCAFs) and inflammatory CAFs (iCAFs), respectively ...
Mengyu Tao, Wenting Liu, Jianhua Chen, Rujiao Liu, Jianling Zou, Bo Yu, Chenchen Wang, Mingzhu Huang, Qingjian Chen, Zhe Zhang, Zhiyu Chen, Haoyu Sun, Cheng Zhou, Shuguang Tan, Yuxuan Zheng, Hongxia Wang   +15 more
wiley   +1 more source

Circadian modulation of microglial physiological processes and immune responses

Glia, Volume 71, Issue 2, Page 155-167, February 2023., 2023
Main Points Microglia are rhythmic cells with an oscillatory expression in clock genes, cytokines, and other microglial markers. Microglial circadian rhythms determine their physiological function and immune responses. Abstract Microglia is considered the central nervous system (CNS) resident macrophages that establish an innate immune response against
Mara A. Guzmán‐Ruiz, Natalí N. Guerrero‐Vargas, Alejandra Lagunes‐Cruz, Shellye González‐González, Jesús Enrique García‐Aviles, Gabriela Hurtado‐Alvarado, Rebeca Mendez‐Hernández, Anahí Chavarría‐Krauser, Jean‐Pascal Morin, Virginia Arriaga‐Avila, Ruud M. Buijs, Rosalinda Guevara‐Guzmán   +11 more
wiley   +1 more source

Design and Validation of a Multiplex KIR and HLA Class I Genotyping Method Using Next Generation Sequencing

Frontiers in Immunology, 2018
Killer cell immunoglobulin-like receptors (KIR), considered the most polymorphic natural killer (NK) cell regulators, bind HLA class-I molecules or still unknown ligands.
Laia Closa, Laia Closa, Francisco Vidal, Francisco Vidal, Francisco Vidal, Maria J. Herrero, Jose L. Caro, Jose L. Caro   +7 more
doaj   +1 more source

Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Advanced Science, EarlyView.
Baicalin alleviates E. coli‐induced intestinal inflammation through dual mechanisms: direct inhibition of the TLR4/IRF/STAT signaling pathway to modulate macrophage polarization and antigen presentation, thereby regulating Th17/Treg cell differentiation; and microbiota‐mediated indirect effects via increasing Lactobacillus amylovorus abundance and ...
Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen, Hongfu Zhang   +10 more
wiley   +1 more source