Results 261 to 270 of about 159,586 (333)

Trypanosoma cruziInfection Modulates In Vivo Expression of Major Histocompatibility Complex Class II Molecules on Antigen-Presenting Cells and T-Cell Stimulatory Activity of Dendritic Cells in a Strain-Dependent Manner

, 2003
Catalina D. Alba Soto, Gerardo A. Mirkin, María Elisa Solana, S. M. González Cappa   +3 more
openalex   +1 more source

Extracellular vesicles released from melanoma cells constitutively expressing MHC class II promote immune evasion and cancer progression

The FEBS Journal, EarlyView.
Here, we report the role of extracellular vesicles (EVs) released from melanoma cells constitutively expressing MHC class II in the regulation of immune cell functions and melanoma metastasis. In particular, we observed an increased localization of HLA‐DRα, CAM receptors, PD‐L1, and STAT3 signaling proteins in the EVs.
Francesca Costantini, Caterina Di Sano, Samuele Raccosta, Mauro Manno, Giovanna Barbieri   +4 more
wiley   +1 more source

Genetic basis of disease resistance to coccidiosis and necrotic enteritis in chickens. [PDF]

Poult Sci
Niraula A, Dalloul RA.
europepmc   +1 more source

TNF‑α Gene Polymorphisms as Determinants of Alloantibody Emergence in Hemophilia: A Systematic Review and Meta‐Analysis

Haemophilia, EarlyView.
ABSTRACT Introduction Inhibitor development remains one of the most serious complications of replacement therapy in patients with hemophilia. Tumour necrosis factor‐alpha (TNF‐α) is a key pro‐inflammatory cytokine, and its genetic variants have been implicated in immune‐related conditions.
Alessandra Faustino da Conceição Bezerra, Natã Abner Andrade Carito de Sousa, Suely Meireles Rezende, Renan Pedra de Souza   +3 more
wiley   +1 more source

Controlling intracellular processing to enhance spherical nucleic acid immune stimulation. [PDF]

Proc Natl Acad Sci U S A
Kang J, Teplensky MH, Dittmar JW, Evangelopoulos M, Hwang J, Mirkin CA.   +5 more
europepmc   +1 more source

The geometry of pMHC‐coated nanoparticles and T‐cell receptor clusters governs the sensitivity‐specificity trade‐off in T‐cell response: a modeling investigation

Immunology &Cell Biology, EarlyView.
Using numerical Monte Carlo simulations of nanoparticle‐T‐cell receptors binding, we show that the spatial organization of surface receptors is important for affinity‐based discrimination of peptide‐major histocompatibility complex ligands. Interaction geometry modulates the sensitivity of the T‐cell response to both ligand concentration and binding ...
Louis Richez, Anmar Khadra
wiley   +1 more source

Principles of whole organ transplantation [PDF]

, 1984
Iwatsuki, S, Shaw, BW, Starzl, TE
core  

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Clustering-based identification of immune-related gene signatures in hepatocellular carcinoma. [PDF]

Ecancermedicalscience
Brahmaiah J, Adiga U, Augustine AJ, Vasishta S.   +3 more
europepmc   +1 more source

Interferon Regulatory Factor 2 (IRF2) Suppression Enhances Murine Cardiac Allograft Survival Through Immune Evasion

Immunology, EarlyView.
Our data show that suppressing IRF2, genetically or by siRNA, modulates PD‐L1 and MHC‐I levels. This induced immune‐evasive state critically underlies the significantly prolonged survival of cardiac allografts, revealing a novel therapeutic avenue.
Li Tian, Man Zhang, Yuliang Guo, Sheng Chang, Zhonghua Klaus Chen, Hongmin Zhou   +5 more
wiley   +1 more source