Results 121 to 130 of about 64,134 (148)

Tolerance of class I histocompatibility antigens expressed extrathymically

Nature, 1989
Although convincing evidence has been obtained for the imposition of self-tolerance by the intrathymic deletion of self-reactive T cells, the development of tolerance to antigens which are expressed only in the periphery is not so well understood.
G, Morahan, J, Allison, J F, Miller
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Proteolysis and class I major histocompatibility complex antigen presentation

Immunological Reviews, 1999
Summary: The class I major histocompatibility complex (MHC class 1) presents 8–10 residue peptides to cytotoxic T lymphocytes. Most of these antigenic peptides are generated during protein degradation in the cytoplasm and are then transported into the endoplasmic reticulum by the transporter associated with antigen processing (TAP), Several lines of ...
I A, York, A L, Goldberg, X Y, Mo, K L, Rock   +3 more
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Structure of Class I Major Histocompatibility Antigens

1983
H-2 antigens were discovered by Gorer (1936) as a blood group system associated with histocompatibility between mouse strains. Later research indicated that H-2 antigens were encoded by a series of genes, hence the designation H-2 complex (J. Klein, 1975).
E S, Kimball, J E, Coligan
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Generation of major histocompatibility complex class I antigens

Microbes and Infection, 2003
Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules on the surface of antigen-presenting cells is an effective extracellular representation of the intracellular antigen content. The intracellular proteasome-dependent proteolytic machinery is required for generating MHC class I-presented peptides.
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Molecules Related To Class-I Major Histocompatibility Complex Antigens

Annual Review of Immunology, 1990
Article de synthese sur la structure et l'expression de molecules apparentees aux molecules de classe I chez la souris. Etat de la recherche sur les molecules solubles, liees a des phospholipides et membranaires comprises dans ce groupe; etude comparative des structures de ces ...
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Structure of the human class I histocompatibility antigen, HLA-A2

Nature, 1987
The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices.
P J, Bjorkman, M A, Saper, B, Samraoui, W S, Bennett, J L, Strominger, D C, Wiley   +5 more
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ALLOSPECIFIC MONOCLONAL ANTIBODIES RECOGNIZING RAT CLASS I AND CLASS II HISTOCOMPATIBILITY ANTIGENS

Transplantation, 1982
Rat-mouse hybridomas have been developed producing monoclonal antibodies which recognize rat major histocompatibility complex specificities. Splenic lymphocytes from a LEW (RT1l) rat alloimmunized against ACI (Rt1a) splenocytes were used for hybridoma production.
E E, Engel, R D, Guttmann, A, Fuks
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Antigen Presentation by Major Histocompatibility Complex Class I-B Molecules

Annual Review of Immunology, 1994
Class I-b genes constitute the majority of MHC class I loci. These monomorphic or oligomorphic molecules have been described in many organisms; they are best characterized in the mouse, which contains a substantial number of potentially intact genes.
S M, Shawar, J M, Vyas, J R, Rodgers, R R, Rich   +3 more
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The rat placenta expresses paternal class I major histocompatibility antigens

Journal of Reproductive Immunology, 1986
The expression of paternally inherited class I MHC antigens on the placental trophoblast of the rat has been investigated using a mouse anti-rat monoclonal antibody (MN4-91-6) in an indirect immunoperoxidase labelling assay on cryostat sections. Strong specific staining was obtained on the spongy zone trophoblast of the mature placenta from DA male ...
W D, Billington, F J, Burrows
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Post-proteasomal antigen processing for major histocompatibility complex class I presentation

Nature Immunology, 2004
Peptides presented by major histocompatibility complex class I molecules are derived mainly from cytosolic oligopeptides generated by proteasomes during the degradation of intracellular proteins. Proteasomal cleavages generate the final C terminus of these epitopes.
Kenneth L, Rock, Ian A, York, Alfred L, Goldberg   +2 more
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