Results 261 to 270 of about 23,603,276 (341)

Tissue Resident Memory Cells: Friend or Foe?

Immunology, EarlyView.
Tissue‐resident memory T cells (TRM cells) are specialised immune cells in barrier tissues like the lungs, skin and gut, providing rapid host defence and tumour surveillance. Their retention and differentiation are regulated by molecules such as CD69, CD103 and TGF‐β. Dysregulation of TRM cells can lead to chronic activation, driving conditions such as
Chidimma F. Chude, Jude E. Uzonna, Janilyn Arsenio   +2 more
wiley   +1 more source

Clinical applications and methodology updates in HLA typing. [PDF]

BMC Immunol
Feng K, Chang L, Yan Y, Sun H, Liu Y, Song S, Nuermaimaiti A, Halemubieke S, Mei L, Su Q, Liu X, Lu Z, Ji H, Wang L.   +13 more
europepmc   +1 more source

Aire and Fezf2 Shape the Medullary Thymic Epithelial Cell Immunopeptidome for Central Tolerance

Immunology, EarlyView.
Central tolerance is shaped not merely by promiscuous gene expression in medullary thymic epithelial cells (mTECs), but by the subset of self‐peptides ultimately presented on MHC class II molecules. We propose a multilayered framework in which AIRE/Aire and FEZF2/Fezf2, together with specialised differentiation programmes—including thymic mimetic‐cell ...
Geraldo Aleixo Passos, Vitor Marcel Faça, Eduardo Antonio Donadi, Ana Paula Masson, Carlos Crippa Coletto, Gustavo Ronconi Roza   +5 more
wiley   +1 more source

Long-term major histocompatibility complex class I suppression in astronauts and clinical implications. [PDF]

Commun Biol
LeRoy E, Kim J, Ruland H, Schanzer N, Sakharkar A, Innes L, Feinstein Z, Gamboa DZ, Chen R, Arikatla MR, Kurt KC, Crucian BE, Schmidt MA, Mason CE.   +13 more
europepmc   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Identification of Ten New HLA Alleles by Next-Generation Sequencing. [PDF]

HLA
Loginova M, Morozova N, Dudina J, Paramonov I.   +3 more
europepmc   +1 more source

Stem Cells From Dental Pulp, Periodontal Tissues, and Other Oral Sources: Biological Concepts and Regenerative Potential

Journal of Periodontal Research, EarlyView.
A graphical abstract recapping the different sources of dental, periodontal, and other oral‐derived mesenchymal stromal cells (MSCs) and their regenerative mechanisms and potentials. The review's article findings bridge fundamental biological science with translational advances, highlighting the significance of MSCs in craniofacial regenerative ...
Karim M. Fawzy El‐Sayed, Sara El Moshy, Israa Ahmed Radwan, Dina Rady, Aiah A. El‐Rashidy, Marwa M. S. Abbass, Christof E. Dörfer   +6 more
wiley   +1 more source

A Platform for High-throughput and Ultrasensitive Immunopeptidomics. [PDF]

Mol Cell Proteomics
Gul A, Van Moortel L, Willems P, Aernout I, Pedró-Cos L, Ferrell KC, Boucher K, Staes A, Devos S, Lentacker I, Vandekerckhove B, Demangel C, Thery F, Impens F.   +13 more
europepmc   +1 more source

The Role of Viruses in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
This narrative review aimed to summarize current evidence on the presence and potential pathogenic role of viruses in periodontitis. Design: Narrative Review; Population: Patients with periodontitis; Exposure: Detection of viruses in oral samples (biopsies, saliva, gingival crevicular fluid, subgingival plaque, blood); Outcome: Viral prevalence, load ...
Kim Natalie Stolte, Jørgen Slots, Henrik Dommisch   +2 more
wiley   +1 more source

Understanding the structure of swine leukocyte antigen class I molecules. [PDF]

Cell Mol Biol Lett
Gao YY, Li HY, Yang SY, Sang CJ, Cao YD, Tang Y, Li ZB, Hu GX, Gao FS.   +8 more
europepmc   +1 more source