Results 241 to 250 of about 23,603,276 (341)

EXPRESSION AND FUNCTION OF A NONGLYCOSYLATED MAJOR HISTOCOMPATIBILITY CLASS I ANTIGEN

EXPRESSION AND FUNCTION OF A NONGLYCOSYLATED MAJOR HISTOCOMPATIBILITY CLASS I ANTIGEN
The major histocompatibility class I antigens, expressed in most somatic cells, have carbohydrate moieties. We constructed mutant mouse MHC class I genes in which codons for the N-linked glycosylation sites were replaced by those of other amino acids.
openaire   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, EarlyView.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

HLA Class I Histocompatibility Antigen, A-1 Alpha Chain [PDF]

, 2020
openaire   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Association between Alzheimer's disease and MHC-I antigen processing and presentation pathway: a narrative review. [PDF]

Front Immunol
Wang C, Yun Q, Zhang Z, Zhao H, Lin F, Cao H.   +5 more
europepmc   +1 more source

The Role of IGF2BP3‐Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer

Cancer Science, EarlyView.
Koumine binds IGF2BP3 and promotes its proteasomal degradation, reducing m6A on EED mRNA, accelerating EED decay, lowering H3K27me3, and promoting IRF transcription, thereby restoring MHC‐I and enhancing CD8+ T cell killing. ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I
Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng   +10 more
wiley   +1 more source

Identification of the Novel HLA-C*03:536:02 Allele in a Chinese Cord Blood Donor. [PDF]

HLA
Dong L, Wang F, Li Q, He Y, Zhu F.
europepmc   +1 more source

HLA Class I Histocompatibility Antigen, A-24 Alpha Chain [PDF]

, 2020
openaire   +1 more source

Treatment‐Free Remission in Chronic Myeloid Leukemia: Toward Precision and Personalized Approaches to Functional Cure

Cancer Science, EarlyView.
Immune surveillance of residual leukemic stem cells after tyrosine kinase inhibitor discontinuation involves coordinated NK‐cell, CTL, Treg, pDC, and neutrophil activity that predicts treatment‐free remission, while exhausted CTLs and Treg expansion predict relapse in chronic myeloid leukemia.
Hiroshi Ureshino, Shinya Kimura
wiley   +1 more source

Detection of RBC-bound antibodies using flow cytometry and their correlation with HLA polymorphism. [PDF]

Front Immunol
Ullah A, Liu L, Qi X, Liu H.
europepmc   +1 more source