Results 221 to 230 of about 66,572 (262)
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Tolerance of class I histocompatibility antigens expressed extrathymically
Nature, 1989Although convincing evidence has been obtained for the imposition of self-tolerance by the intrathymic deletion of self-reactive T cells, the development of tolerance to antigens which are expressed only in the periphery is not so well understood.
G, Morahan, J, Allison, J F, Miller
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Proteolysis and class I major histocompatibility complex antigen presentation
Immunological Reviews, 1999Summary: The class I major histocompatibility complex (MHC class 1) presents 8–10 residue peptides to cytotoxic T lymphocytes. Most of these antigenic peptides are generated during protein degradation in the cytoplasm and are then transported into the endoplasmic reticulum by the transporter associated with antigen processing (TAP), Several lines of ...
I A, York +3 more
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Structure of the human class I histocompatibility antigen, HLA-A2
Nature, 1987The class I histocompatibility antigen from human cell membranes has two structural motifs: the membrane-proximal end of the glycoprotein contains two domains with immunoglobulin-folds that are paired in a novel manner, and the region distal from the membrane is a platform of eight antiparallel beta-strands topped by alpha-helices.
P J, Bjorkman +5 more
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ANTIGEN PROCESSING AND PRESENTATION BY THE CLASS I MAJOR HISTOCOMPATIBILITY COMPLEX
Annual Review of Immunology, 1996▪ Abstract Major histocompatibility complex (MHC) class I molecules bind peptides derived from cellular proteins and display them for surveillance by the immune system. These peptide-binding molecules are composed of a heavy chain, containing an antigen-binding groove, which is tightly associated with a light chain (β2-microglobulin).
I A, York, K L, Rock
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Structure of Class I Major Histocompatibility Antigens
1983H-2 antigens were discovered by Gorer (1936) as a blood group system associated with histocompatibility between mouse strains. Later research indicated that H-2 antigens were encoded by a series of genes, hence the designation H-2 complex (J. Klein, 1975).
E S, Kimball, J E, Coligan
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Generation of major histocompatibility complex class I antigens
Microbes and Infection, 2003Presentation of antigenic peptides by major histocompatibility complex (MHC) class I molecules on the surface of antigen-presenting cells is an effective extracellular representation of the intracellular antigen content. The intracellular proteasome-dependent proteolytic machinery is required for generating MHC class I-presented peptides.
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Expression of class I and class II major histocompatibility complex antigens on human hepatocytes
Hepatology, 1988We analyzed whether normal human hepatocytes, which normally do not display Class II major histocompatibility complex antigens, can be induced to express them in vitro, and whether this induction has an in vivo counterpart in chronic liver diseases.
A. Franco +5 more
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Presentation of Exogenous Antigen with Class I Major Histocompatibility Complex Molecules
Science, 1990Soluble antigens (Ags) in the extracellular fluids are excluded from the class I major histocompatibility complex (MHC)-restricted pathway of Ag presentation in most cells. However, an exogenous Ag can be internalized, processed, and presented in association with class I MHC molecules on specialized Ag-presenting cells (APCs).
K L, Rock, S, Gamble, L, Rothstein
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The rat placenta expresses paternal class I major histocompatibility antigens
Journal of Reproductive Immunology, 1986The expression of paternally inherited class I MHC antigens on the placental trophoblast of the rat has been investigated using a mouse anti-rat monoclonal antibody (MN4-91-6) in an indirect immunoperoxidase labelling assay on cryostat sections. Strong specific staining was obtained on the spongy zone trophoblast of the mature placenta from DA male ...
W D, Billington, F J, Burrows
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Antigen Presentation by Major Histocompatibility Complex Class I-B Molecules
Annual Review of Immunology, 1994Class I-b genes constitute the majority of MHC class I loci. These monomorphic or oligomorphic molecules have been described in many organisms; they are best characterized in the mouse, which contains a substantial number of potentially intact genes.
S M, Shawar +3 more
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