Results 201 to 210 of about 23,603,276 (341)

Genomic Assessment of Reintroduced African Wild Dogs Informs Conservation Translocations

open access: yesAnimal Conservation, EarlyView.
Few reintroduction and translocation programs incorporate genomic assessments into management planning, despite ongoing debate over how founder individuals should be selected. Here, we assess the genomic composition of reintroduced African wild dog (Lycaon pictus) populations in private reserves in South Africa, comparing them with a free‐roaming ...
Michou Weimar   +4 more
wiley   +1 more source

Novel Bispecific Engagers Targeting the CεmX Domain of mIgE‐Expressing Cells

open access: yesAllergy, EarlyView.
We developed bispecific TCE & NKCE targeting the CεmX domain of mIgE to eliminate IgE‐producing cells. Both constructs demonstrated potent, specific, dose‐dependent cytotoxicity and selective immune activation in vitro. These results highlight their promise as off‐the‐shelf, potentially curative therapeutics for IgE‐associated allergic diseases ...
Constantin Möller   +16 more
wiley   +1 more source

Mapping Allergen B‐ and T‐Cell Epitopes: Technological Advances and Their Role in Precision Allergy Therapy

open access: yesAllergy, EarlyView.
ABSTRACT Allergic diseases arise from aberrant immune recognition of otherwise harmless environmental proteins and are driven by epitope‐specific interactions between allergens and the adaptive immune system. Although component‐resolved diagnostics have improved molecular characterisation of sensitization, they remain limited to whole‐allergen ...
Mark Møiniche   +11 more
wiley   +1 more source

Expression of major histocompatibility complex class I antigens as a strategy for the potentiation of immune recognition of tumor cells.

open access: yesProceedings of the National Academy of Sciences of the United States of America, 1986
Ken-ichi Tanaka   +4 more
semanticscholar   +1 more source

Nomenclature on Immune‐Mediated Drug Reactions: An EAACI Position Paper

open access: yesAllergy, EarlyView.
ABSTRACT Over the past several decades, there have been significant advances in our understanding of both immunological and pharmacological mechanisms of adverse drug reactions (ADRs). Immune‐mediated drug reactions (IMDRs) represent a small proportion of ADRs and are caused by a pathological activation of the immune system or inflammatory pathways ...
Maria J. Torres   +19 more
wiley   +1 more source

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