Results 51 to 60 of about 68,749 (310)

The Clinical Application of Neoantigens in Esophageal Cancer

Frontiers in Oncology, 2021
Esophageal cancer (EC) is a common malignant tumor with poor prognosis, and current treatments for patients with advanced EC remain unsatisfactory. Recently, immunotherapy has been recognized as a new and promising approach for various tumors.
Yi-Min Gu, Yue Zhuo, Long-Qi Chen, Yong Yuan   +3 more
doaj   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Prognostic significance of tumor microenvironment assessed by machine learning algorithm in surgically resected non‐small cell lung cancer

Cancer Reports, EarlyView., 2023
Abstract Background A methodology to assess the immune microenvironment (IME) of non‐small cell lung cancer (NSCLC) has not been established, and the prognostic impact of IME factors is not yet clear. Aims This study aimed to assess the IME factors and evaluate their prognostic values. Methods and Results We assessed CD8+ tumor‐infiltrating lymphocyte (
Yukihiro Terada, Mitsuhiro Isaka, Akira Ono, Takuya Kawata, Masakuni Serizawa, Keita Mori, Koji Muramatsu, Kiyoshi Tone, Hirotsugu Kenmotsu, Keiichi Ohshima, Kenichi Urakami, Takeshi Nagashima, Masatoshi Kusuhara, Yasuto Akiyama, Takashi Sugino, Toshiaki Takahashi, Yasuhisa Ohde   +16 more
wiley   +1 more source

Expression of CD163 and major histocompatibility complex class I as diagnostic markers for idiopathic inflammatory myopathies

Arthritis Research & Therapy
Background To develop an inflammation-related immunohistochemistry marker-based algorithm that confers higher diagnostic ability for idiopathic inflammatory myopathies (IIMs) than IIM-related histopathologic features.
Byeongzu Ghang, So Hye Nam, Wonho Choi, Hwa Jung Kim, Jungsun Lee, Doo-Ho Lim, Soo Min Ahn, Ji Seon Oh, Seokchan Hong, Yong-Gil Kim, Chang-Keun Lee, Jinseok Kim, Bin Yoo, Soo Jeong Nam   +13 more
doaj   +1 more source

HLA class I-restricted minor histocompatibility antigens.

, 2016
HLA class I-restricted minor histocompatibility antigens.
Marieke Griffioen (119817), Dyantha I. van der Lee (3115227), Margot J. Pont (3115230), J. H. Frederik Falkenburg (210432)   +3 more
core   +1 more source

Clinical Spectrum and Outcomes of SOX1 Antibody‐Associated Paraneoplastic Neurological Syndromes: A Chinese Cohort Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background SOX1 antibody‐positive paraneoplastic neurological syndromes (PNS) exhibit significant population‐specific clinical heterogeneity. While Western cohorts predominantly manifest Lambert‐Eaton myasthenic syndrome (65%–80%), comprehensive clinical characterization and treatment response data in Asian populations remain critically ...
Jin‐Long Ye, Zu‐Ying Kuang, Bo Li, Meng‐Qiu Pan, Li‐Hua Zhou, Yang‐Yang Dai, Si‐Fen Xie, Xian‐Guang Lin, Ye‐Peng Hu, Li‐Hong Jiang, Zhan‐Hang Wang, Wei‐Jing Zhang   +11 more
wiley   +1 more source

Decoupling peptide binding from T cell receptor recognition with engineered chimeric MHC-I molecules

Frontiers in Immunology, 2023
Major Histocompatibility Complex class I (MHC-I) molecules display self, viral or aberrant epitopic peptides to T cell receptors (TCRs), which employ interactions between complementarity-determining regions with both peptide and MHC-I heavy chain ...
Georgia F. Papadaki, Georgia F. Papadaki, Omar Ani, Tyler J. Florio, Tyler J. Florio, Michael C. Young, Michael C. Young, Julia N. Danon, Julia N. Danon, Yi Sun, Yi Sun, Devin Dersh, Nikolaos G. Sgourakis, Nikolaos G. Sgourakis   +13 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, EarlyView.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

Antigen processing for MHC class II presentation via autophagy

Frontiers in Immunology, 2012
T cells recognize proteolytic fragments of antigens that are presented to them on major histocompatibility complex (MHC) molecules. MHC class I molecules present primarily products of proteasomal proteolysis to CD8+ T cells, while MHC class II molecules ...
Christian eMunz
doaj   +1 more source

HLA‐A*24:02 increase the risk of allopurinol‐induced drug reaction with eosinophilia and systemic symptoms in HLA‐B*58:01 carriers in a Korean population; a multicenter cross‐sectional case‐control study

Clinical and Translational Allergy, 2022
Background HLA‐B*58:01 is a well‐known risk factor for allopurinol‐induced severe cutaneous adverse reactions (SCARs). However, only a minority of HLA‐B*58:01 carriers suffer SCARs after taking allopurinol.
Mi‐Yeong Kim, James Yun, Dong‐Yoon Kang, Tae Hee Kim, Min‐Kyung Oh, Sunggun Lee, Min‐Gyu Kang, Young‐Hee Nam, Jeong‐Hee Choi, Min‐Suk Yang, Seung Seok Han, Hajeong Lee, Hyun‐Jai Cho, Jaeseok Yang, Kook‐Hwan Oh, Yon Su Kim, Jae Woo Jung, Kye Hwa Lee, Hye‐Ryun Kang   +18 more
doaj   +1 more source