Results 131 to 140 of about 453,877 (390)

Iron Deficiency Impairs Dendritic Cell Development and Function, Compromising Host Anti‐Infection Capacity

Advanced Science, EarlyView.
Iron deficiency reduces monocyte dendritic cell progenitor (MDP) numbers by inhibiting migration and proliferation while promoting apoptosis, subsequently reducing downstream common dendritic cell precursors (CDP) and dendritic cell (DC). Impaired DCs enter the lungs via blood circulation, where reduced antigen presentation impairs T‐cell activation ...
Quanzhong Ren, Xiaotong Xu, Zheng Dong, Jiahuang Qiu, Qing'e Shan, Rui Chen, Yajun Liu, Juan Ma, Sijin Liu   +8 more
wiley   +1 more source

Non-canonical Functions of Macroautophagy Proteins During Endocytosis by Myeloid Antigen Presenting Cells

Frontiers in Immunology, 2018
Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation.
Christian Münz
doaj   +1 more source

Temporal dynamics in immunological synapse: Role of thermal fluctuations in signaling [PDF]

, 2016
The article analyzes the contribution of stochastic thermal fluctuations in the attachment times of the immature T-cell receptor TCR: peptide-major-histocompatibility-complex pMHC immunological synapse bond. The key question addressed here is the following: how does a synapse bond remain stabilized in the presence of high frequency thermal noise that ...
arxiv   +1 more source

Murine liver allograft transplantation: Tolerance and donor cell chimerism [PDF]

, 1994
Nonarterialized orthotopic liver transplantation with no immunosuppression was performed in 13 mouse‐strain combinations. Two strain combinations with major histocompatibility complex class I and class II and minor histocompatibility complex disparity ...
Arnold, Billingham, Billingham, Billingham, Calne, Calne, Cohen, Corry, Coutinho, Dahmen, Davies, Demetris, Demetris, Garnier, Goulmy, Hoffmann, Houssaint, Jerne, Kamada, Liegeois, Liegeois, Mayumi, Monaco, Monaco, Murase, Ono, Peacock, Perelson, Qian, Rao, Russell, Russell, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Starzl, Steinman, Steinman, Strelein, Thomas, Wood, Zimmerman   +45 more
core   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

LincNEAT1 Encoded‐NEAT1‐31 Promotes Phagocytosis by Directly Activating the Aurora‐A–PI3K–AKT Pathway

Advanced Science, EarlyView.
LincNEAT1 Encoded‐NEAT1‐31 micropeptide directly binds with Aurora‐A and enhanced AKT pathways to pormotes phagocytosis against multi cancer cells. Abstract Macrophages play vital roles in innate and adaptive immunity, and their essential functions are mediated by phagocytosis and antigen presentation.
Jie Li, Jing Zhang, Xixi Li, Xin Liu, Bo Zeng, Jiayue Luo, Huijin Wang, Hanbing Zhang, Xinya Gao   +8 more
wiley   +1 more source

Lateral diffusion of wild-type and mutant Ld antigens in L cells [PDF]

, 1984
We have compared the lateral diffusion of intact transmembrane proteins, wild-type H-2Ld antigens, with that of mutants truncated in the cytoplasmic domain.
Edidin, Michael, Zuñiga, Martha
core   +1 more source

The natural immune response to inhaled soluble protein antigens involves major histocompatibility complex (MHC) class I-restricted CD8+ T cell-mediated but MHC class II-restricted CD4+ T cell-dependent immune deviation resulting in selective suppression of immunoglobulin E production

Journal of Experimental Medicine, 1993
The immunological basis for atopy is currently ascribed to an inherent bias in the CD4+ T cell response to nonreplicating antigens presented at mucosal surfaces, resulting in dominance of the T helper 2 (Th2) interleukin 4 (IL-4)-producing phenotype ...
C. Mcmenamin, P. Holt
semanticscholar   +1 more source

Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas

Advanced Science, EarlyView.
Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang, Guangmin Zheng, Xiaoyong Hu, Feng Tian, Tuo Li, Zheng Zhang, Kan Gong, Shiwei Chen, Lin Yuan, Yu Qi, Lin Li, Daofu Cheng, Liu Liu, Fuqiang Liu, Yujing Sun, Xiangdong Fang, Ruxing Zhao, Bing Liu, Chao Zhang   +18 more
wiley   +1 more source

A lentiviral vector encoding fusion of light invariant chain and mycobacterial antigens induces protective CD4+ T cell immunity

Cell Reports, 2022
Summary: Lentiviral vectors (LVs) are highly efficient at inducing CD8+ T cell responses. However, LV-encoded antigens are processed inside the cytosol of antigen-presenting cells, which does not directly communicate with the endosomal major ...
Jodie Lopez, François Anna, Pierre Authié, Alexandre Pawlik, Min-Wen Ku, Catherine Blanc, Philippe Souque, Fanny Moncoq, Amandine Noirat, David Hardy, Wladimir Sougakoff, Roland Brosch, Françoise Guinet, Pierre Charneau, Laleh Majlessi   +14 more
doaj