Results 111 to 120 of about 63,510 (311)
Exploiting the retrograde transport of disarmed toxins for the delivery of exogenous antigens into MHC class 1 presentation pathway [PDF]
The targeting of exogenous antigen into the MHC class 1-restricted presentation pathway is required for the induction of cytotoxic T lymphocytes (CTL) which have been shown to be an important component of the protective response to intracellular ...
Noakes, Karen
core
The transmembrane domain of the adenovirus E3/19K protein acts as an ER retention signal and contributes to intracellular sequestration of MHC class I molecules [PDF]
, 2013 The human adenovirus E3/19K-protein is a type-I transmembrane glycoprotein of the endoplasmic reticulum (ER) that abrogates cell-surface transport of MHC class-I (MHC-I) and MICA/B-molecules.
Ruszics, Zsolt +3 more
core
Arthritis &Rheumatology, EarlyView.Objective Rituximab, a CD20+ B cell depletion therapy, is frequently used to treat systemic lupus erythematosus (SLE). However, variability in patient response highlights the need for a deeper understanding of the underlying immune cell dynamics of B cell depletion and repopulation.
Haerin Jang +9 more
wiley +1 more source
, 2005 After the initiation of the human genome sequencing project and the introduction of the field of 'bioinformatics', interest in human genetic diversity studies has been increased.
Dunn, David Suliman
core
, 1999 Expression of major histocompatibility class II antigens on polymorphonuclear neutrophils in patients with Wegener's granulomatosis.BackgroundWegener's granulomatosis is a systemic inflammatory disease of unknown etiology.
Wagner, Christof +6 more
core +1 more source
Revista Cubana de Hematología, Inmunología y Hemoterapia, 2005 Se realizó un estudio de la frecuencia fenotípica y génica de los antígenos del sistema principal de histocompatibilidad HLA en personas no relacionadas, supuestamente sanas, tomadas como muestra de la población cubana.
Luz M Morera Barrios +8 more
doaj
Resting Porcine T Lymphocytes Expressing Class II Major Histocompatibility Antigen
Immunobiology, 1991 The immune system of swine is unique in that the expression of CD4 and CD8 antigens defines four subpopulations of resting, extrathymic (CD1-) T lymphocytes in the circulation as well as in lymphoid tissue. Here it is documented that the specialty of the porcine T lymphocyte compartment extends to the expression of class II MHC (SLA) antigens.
A, Saalmüller +2 more
openaire +2 more sources
T cells, the Next Big Target in Axial Spondyloarthritis?
Arthritis &Rheumatology, EarlyView.Axial spondyloarthritis (axSpA) is a chronic inflammatory disease characterized by complex immune dysregulation, with T cells playing a central role in its pathogenesis. In this review, we synthesize current knowledge on diverse T cell subsets in axSpA, their pathogenic mechanisms, and emerging therapeutic strategies targeting these cells. We highlight
Mansi K. Aparnathi, Nigil Haroon
wiley +1 more source
Arthritis &Rheumatology, Accepted Article.Objective Anti‐homocitrullinated protein/peptide antibodies are specific to rheumatoid arthritis (RA) and predictive of worse prognosis, suggesting a pathogenic role for autoreactivity to homocitrullinated peptides (HomoCitP). However, T‐cell responses to HomoCitP remain largely unexplored.
Sofya Ulanova +6 more
wiley +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source