Results 91 to 100 of about 63,510 (311)

Expression of MHC class I and class II antigens in pancreatic adenocarcinomas

, 1996
The antigens encoded by the major histocompatibility complex (MHC) are cell surface glycoproteins that play a fundamental role in the regulation of the immune response.
SARTORIS S, ENNAS, MARIA GRAZIA, MARTIGNONI G, SCARPA A, SCUPOLI MT, CESTARI T, ACCOLLA RS, LEMOINE NR, NICOLIS M, ZAMBONI G, TOSI G   +10 more
core   +1 more source

High-throughput high-resolution class I HLA genotyping in East Africa. [PDF]

, 2010
HLA, the most genetically diverse loci in the human genome, play a crucial role in host-pathogen interaction by mediating innate and adaptive cellular immune responses. A vast number of infectious diseases affect East Africa, including HIV/AIDS, malaria,
Leonard Maboko, Eller, Michael, Jerome Kim, Rebecca N Koehler, Francine E McCutchan, Michael Eller, Christian T Bautista, Hoelscher Michael, Eller, Leigh Anne, Jeffrey R Currier, Currier Jeffrey R., Nelson L Michael, Michael, Nelson L., Kijak, Gustavo H, Maboko Leonard, Michael, Nelson L, McCutchan, Francine E., Michael Nelson L., Maboko, Leonard, Walsh, Anne M, Wabwire-Mangen Fred, Fred Wabwire-Mangen, Wabwire-Mangen, Fred, Currier, Jeffrey R, Eller Michael, McCutchan, Francine E, Eric E Sanders-Buell, Sanders-Buell, Eric E., Robb, Merlin L, Robb Merlin L., Kijak Gustavo H., Leigh Anne Eller, Kim Jerome, Robb, Merlin L., Bautista Christian T., Anne M Walsh, Hoelscher, Michael, Kijak, Gustavo H., Bautista, Christian T, Michael Hoelscher, McCutchan Francine E., Kim, Jerome, Eller Leigh Anne, Koehler, Rebecca N, Merlin L Robb, Bautista, Christian T., Koehler, Rebecca N., Koehler Rebecca N., Sanders-Buell, Eric E, Sanders-Buell Eric E., Walsh, Anne M., Currier, Jeffrey R., Gustavo H Kijak, Walsh Anne M.   +53 more
core   +1 more source

Non-canonical Functions of Macroautophagy Proteins During Endocytosis by Myeloid Antigen Presenting Cells

Frontiers in Immunology, 2018
Endocytosis by myeloid antigen presenting cells such as dendritic cells and macrophages regulates both antigen processing and major histocompatibility complex (MHC) molecule trafficking during antigen presentation.
Christian Münz
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

Immunological basis of differences in disease resistance in the chicken

, 2002
Genetic resistance to diseases is a multigenic trait governed mainly by the immune system and its interactions with many physiologic and environmental factors.
Rebel, J.M.J., Zekarias, B., Huurne, A.A.H.M., ter, Landman, W.J.M., Gruys, E., Pol, J.M.A.   +5 more
core   +1 more source

Humanized immune system animal models and their recent applications

Animal Models and Experimental Medicine, EarlyView.
In this review, we provide an updated and comprehensive overview of the current state of humanized immune system animal model research. We discuss the variety of techniques used to produce humanized mice with their respective strengths and weaknesses, and evaluate the advantages and limitations of these models, including issues with incomplete immune ...
Nicolas Skuli, Rudra B. Amin, A’ishah Bakayoko, Marisa Kruidenier, Sahara Aqui, Sarah J. Skuli, Terence P. Gade   +6 more
wiley   +1 more source

Interferon y Stimulation Modulates the Proteolytic Activity and Cleavage Site Preference of 20S Mouse Proteasomes [PDF]

, 1994
The proteasome is a 700-kD multisubunit enzyme complex with several proteolytically active sites. The enzyme complex is involved in both ubiquitin-dependent and -independent protein degradation and may contribute to the processing of antigens presented ...
Multhaupt, Gerd, Koszinowski, Ulrich H., Kloetzel, Peter-M., Boes, Bettina, Ruppert, Thomas, Hengel, Hartmut   +5 more
core  

Recent advances in the construction of humanized animal models and applications in translational medicine

Animal Models and Experimental Medicine, EarlyView.
Substantial advances have been achieved in the development of humanized mouse models, which have proven highly valuable in evaluating cancer immunotherapies and elucidating the mechanisms of infectious diseases. There is now a growing shift in research toward larger animal models—such as pigs—that offer greater physiological similarity to humans ...
Yanan Lyu, Yong‐Guang Yang, Zheng Hu
wiley   +1 more source

Expression of major histocompatibility complex class I and class II antigens in canine masticatory muscle myositis.

, 2007
Studies in human immune-mediated inflammatory myopathies have documented expression of major histocompatibility complex class I (MHC class I) and class II (MHC class II) antigens on muscle fiber membranes in the presence or absence of cellular ...
PAPPARELLA, SERENELLA, G.D. Shelton, PACIELLO, ORLANDO   +2 more
core  

Molecular basis for cytolytic T-lymphocyte recognition of the murine cytomegalovirus immediate-early protein pp89 [PDF]

, 1988
The murine cytomegalovirus protein pp89, which is encoded by gene ieI, is a nonstructural regulatory protein expressed in the immediate-early phase of the viral replication cycle and located mainly in the nucleus of infected cells.
Reddehase, Matthias J., Del Val, Margarita, Koszinowski, Ulrich H., Schickedanz, Jörg, Volkmer, Hansjürgen, Messerle, Martin, Jonjic, Stipan, Rothbard, Jonathan B.   +7 more
core