Results 211 to 220 of about 453,877 (390)

Purification and characterization of class II histocompatibility antigens from a homozygous human B cell line.

Journal of Biological Chemistry, 1987
J. Gorga, V. Hořejší, D. Johnson, R. Raghupathy, J. Strominger   +4 more
semanticscholar   +1 more source

Antitumor efficacy of intermittent low‐dose erlotinib plus sulindac via MHC upregulation and remodeling of the immune cell niche

International Journal of Cancer, Volume 157, Issue 2, Page 355-370, 15 July 2025.
What's new? Novel immunomodulatory insights derived from experimental models and clinical samples reveal the cancer‐preventive potential of intermittent low‐dose erlotinib plus sulindac (ERL + SUL). This study shows that ERL + SUL treatment upregulates MHC class I and II expression and remodels the immune cell niche, with significant tumor suppression ...
Chakrapani Tripathi, Jorge E. Tovar Perez, Sabeeta Kapoor, Ahmed Muhsin, Wan Mohaiza Dashwood, Yunus Demirhan, Melek Demirhan, Alessandro Shapiro, Altaf Mohammed, Shizuko Sei, Jacklyn Thompson, Mahira Zaheer, Krishna M. Sinha, Powel H. Brown, Michelle I. Savage, Eduardo Vilar, Praveen Rajendran, Roderick H. Dashwood   +17 more
wiley   +1 more source

Engineered strategies for the allergic disease therapy

Interdisciplinary Medicine, EarlyView.
Allergic diseases exist widely across the globe and now there are very limited therapeutics for the treatment of these diseases. In this review, we summarize the recent advances in engineering strategies including nanoemulsion and hydrogel to improve the therapeutic efficacy of allergen‐specific immunotherapy with decreased side effects and long‐term ...
Yun Tian, Xin Wu, Xiaoqi Sun, Lei Rong, Kai Han   +4 more
wiley   +1 more source

Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression

, 1994
Akio Suzumura, Makoto Sawada, Yasuhiro Itoh, Tohru Marunouchi   +3 more
openalex   +1 more source

Expression of Invariant Chain (CD 74) and Major Histocompatibility Complex (MHC) Class II Antigens in the Human Fetus¹ [PDF]

, 2002
Sunil Badve, Charuhas Deshpande, Zhongxue Hua, Lögdberg Lennart   +3 more
openalex   +1 more source

Carbon‐ion irradiation together with autophagy inhibition and immune checkpoint inhibitors protect against pancreatic cancer development in mouse model

Journal of Hepato-Biliary-Pancreatic Sciences, EarlyView.
Abstract Background Pancreatic cancer remains fatal because of resistance to chemo‐, radio‐, and immunotherapies. Carbon‐ion radiotherapy (CIRT) has been beneficial for patients with pancreatic cancer. The purpose of this study was to identify the mechanism by which CIRT exerts its anticancer activity, particularly in combination with immunotherapy ...
Makoto Sudo, Yaoyao Wang, Jingren Wang, Koubun Yasuda, Keiko Mitani, Shuhei Hayashi, Masaki Ohmuraya, Hiroko Tsutsui, Jiro Fujimoto   +8 more
wiley   +1 more source

Thermodynamic Analysis of the Increased Stability of Major Histocompatibility Complex Class II Molecule I-Ek Complexed with an Antigenic Peptide at an Acidic pH [PDF]

, 2003
Keigo Saito, Akinori Sarai, Masayuki Oda, Takachika Azuma, Haruo Kozono   +4 more
openalex   +1 more source

Genital Crohn's disease in pediatrics and genetic associations

JPGN Reports, EarlyView.
Abstract Genital edema is a rare presentation of Crohn's disease (CD), also known as metastatic CD (MCD). This may precede, co‐occur with, or follow gastrointestinal symptoms and present a diagnostic challenge. We aimed to characterize the features, clinical courses, pathogenesis, and outcomes of patients with MCD to increase understanding and promote ...
Erica Chang, Caroline Chinchilla Putzeys, Edward Hoffenberg, Ashish Patel, Elizabeth Hilow, Brad Pasternak   +5 more
wiley   +1 more source

Presentation of Exogenous Antigens on Major Histocompatibility Complex (MHC) Class I and MHC Class II Molecules Is Differentially Regulated during Dendritic Cell Maturation [PDF]

, 2003
Lélia Delamarre, Hilda Holcombe, Ira Mellman   +2 more
openalex   +1 more source

A Preliminary Study on the Therapeutic Role of γδT Cells in Triple‐Negative Breast Cancer

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study was aimed to elucidate the cytotoxic effects of γδT cells on triple‐negative breast cancer (TNBC) cells and assess their antitumor efficacy in a mouse xenograft model. Furthermore, the underlying mechanisms of γδT cell action on TNBC were explored.
Shi Qiu, Qin‐Yu Han, Xian Zhao, Wen‐Jing Li, Xiang‐Qi Li   +4 more
wiley   +1 more source