Results 211 to 220 of about 8,473,299 (309)

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, EarlyView.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

Major histocompatibility complex class II deficiency in Morocco: a 26-year retrospective cohort study. [PDF]

Front Immunol
Kattra AB, Ailal F, Benhsaien I, Rada N, Admou B, Hazime R, Benajiba N, El Hafidi N, Hbibi M, Hida M, Rkain M, El Boussaadni Y, Oulmaati A, Bousfiha AA, El Bakkouri J.   +14 more
europepmc   +1 more source

Bioengineered microbiotic levodopa therapy improves cognition and reduces pathology in a rat model of Alzheimer's disease

British Journal of Pharmacology, EarlyView.
Background and Purpose Degeneration of the pontine noradrenergic and midbrain dopaminergic systems contributes to cognitive‐behavioural disturbances during the prodromal stages of Alzheimer's disease (AD). We developed a genetically engineered, programmable probiotic Escherichia coli Nissle 1917 strain (EcNrhaL‐DOPA) capable of producing L‐3,4 ...
Mona Abdelhamid, Piyush Padhi, Mahsa Gifani, John S. Beck, Jacob P. Thomas, Gargi Khadse, Catherine Kudela, Gregory J. Phillips, Anumantha G. Kanthasamy, Scott E. Counts   +9 more
wiley   +1 more source

Unbiased avidity-based isolation of antigen-specific T cells. [PDF]

J Immunother Cancer
Montoya A, Frank ML, Jiang P, Nie H, Zhang M, Bontekoe E, Slone JK, La Posta L, Sorice SRC, Cascone T, Gillison M, Gibbons DL, Zhang J, Dondossola E, Kavraki L, Wenzel PL, Heymach JV, Reuben A.   +17 more
europepmc   +1 more source

Genomic Evolution and Immune Contexture With Therapeutic Relevance in Pancreatic Neuroendocrine Neoplasms

Cancer Science, EarlyView.
Lineage‐dependent immunogenomic landscapes and biologically informed therapy in pancreatic neuroendocrine neoplasms. Pancreatic neuroendocrine neoplasms display lineage‐dependent immunogenomic landscapes, in which genomic alterations, epigenetic states, antigen‐presentation status, immune‐cell infiltration, and suppressive microenvironments co‐evolve ...
Yohei Tabe, Eito Nakagawa, Daisuke Asano, Eriko Katsuta, Daisuke Ban, Shogo Kumagai   +5 more
wiley   +1 more source

A Platform for High-throughput and Ultrasensitive Immunopeptidomics. [PDF]

Mol Cell Proteomics
Gul A, Van Moortel L, Willems P, Aernout I, Pedró-Cos L, Ferrell KC, Boucher K, Staes A, Devos S, Lentacker I, Vandekerckhove B, Demangel C, Thery F, Impens F.   +13 more
europepmc   +1 more source

Pleiotropic Roles of FBXO11 in Tumorigenesis: Implications for Targeted Therapy

Cancer Science, EarlyView.
This complex comprises of scaffold CUL1, SKP1, RBX1 and FBXO11 receptor. The substrate is phosphorylated by specific kinase enzyme and recognized by the substrate recognition domain. FBXO11 targets numerous substrates for ubiquitination and degradation, FBXO11 substrates mainly include Snail, ZEB1, p53, BCL6, CDT2, CIITA, Cdc25a, hnRNPA2B1, SAMD1 and ...
Yuqi Zhang, Changyi Fan, Shiheng Chen, Tianyue Lu, Yuanyuan Li, Feng Du, Shanshan Wang   +6 more
wiley   +1 more source

Association between Alzheimer's disease and MHC-I antigen processing and presentation pathway: a narrative review. [PDF]

Front Immunol
Wang C, Yun Q, Zhang Z, Zhao H, Lin F, Cao H.   +5 more
europepmc   +1 more source

The Role of IGF2BP3‐Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer

Cancer Science, EarlyView.
Koumine binds IGF2BP3 and promotes its proteasomal degradation, reducing m6A on EED mRNA, accelerating EED decay, lowering H3K27me3, and promoting IRF transcription, thereby restoring MHC‐I and enhancing CD8+ T cell killing. ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I
Qiu Hongqiang, Lin Hailing, Lou Luqi, Wang Linyao, Lin Tian, Shengjie Zhu, Zhang Dongmei, Chen Rong, Mao Yunyi, Wancai Que, Yu Cheng   +10 more
wiley   +1 more source

Intrinsic tumor cell line immunogenicity may drive CAR-independent T cell responses and confound CAR T cell preclinical modeling. [PDF]

J Immunother Cancer
Sheng MK, Firoz WA, Loi K, Vick LV, Collins CP, Nielsen RN, Schmeling JL, Gulati S, Judge SJ, Canter RJ, Monjazeb AM, Zamora AE, Murphy WJ.   +12 more
europepmc   +1 more source