Results 171 to 180 of about 83,183 (296)

Irradiated Liver Cancer Cell Vaccine Transfected With GM‐CSF Induces Specific and Long‐Lasting Anti‐tumour Immunity Through the Synergistic Effect of Oxidised mtDNA and GM‐CSF

Cell Proliferation, EarlyView.
Song et al. developed an mGM‐CSF‐loaded, liver cancer cell‐based vaccine that potently activated dendritic cells and elicited tumour‐specific T cell responses. Mechanistically, radiation‐induced oxidative damage to mitochondrial DNA in cancer cells triggers the cGAS‐STING pathway in DCs, which synergizes with mGM‐CSF‐driven JAK2‐STAT3 signalling to ...
Zhiruo Song, Yujie Jiang, Yu Zhang, Danyi Ao, Chunjun Ye, Xiya Huang, Yingqiong Zhou, Hanle Yang, Ruolan Xia, Jiayuan Ai, Dandan Wan, Aiping Tong, Yuquan Wei, Xuemei He, Aqu Alu, Xiawei Wei   +15 more
wiley   +1 more source

T-cell receptor insights: Determinants of Major Histocompatibility Complex class I versus class II recognition. [PDF]

Protein Sci
De Almeida Mendes M, Chihab L, Nilsson JB, Scheffer L, Nielsen M, Peters B.   +5 more
europepmc   +1 more source

Principles of whole organ transplantation [PDF]

, 1984
Iwatsuki, S, Shaw, BW, Starzl, TE
core  

Impact of G‐CSF on Donor TCR Clonal Diversity and T Cell Function During Donor HSC Mobilisation

Cell Proliferation, EarlyView.
In this study, we found that G‐CSF mobilisation caused a reduction in TCR clonal diversity and down‐regulation of T‐cell function in donors. This may be one of the reasons for the low incidence of GVHD mediated by G‐CSF after allo‐HSCT. Source: Created in BioRender. Li https://BioRender.com/otownki.
Xinye Li, Zhixi Chen, Jie Chen, Xingwei Zhang, Jiamian Zheng, Zirui Liu, Meixue Pan, Yue Li, Bo Yu, Shaohua Chen, Jing Lai, Xianfeng Zha, Liye Zhong, Yikai Zhang, Yangqiu Li   +14 more
wiley   +1 more source

Case Report: A novel CIITA mutation causing MHC class II deficiency: first reported case in Morocco. [PDF]

Front Immunol
Kattra AB, Ailal F, Benhsaien I, Fahi M, Drissi Bourhanbour A, Elamine A, Aadam Z, Errami A, Bousfiha AA, El Bakkouri J.   +9 more
europepmc   +1 more source

Gene Therapy and Gene Editing in Type 1 Diabetes: CRISPR‐Based β‐Cell Replacement and Treg Immune Modulation Approaches

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background Type 1 diabetes mellitus (T1DM) is a chronic autoimmune disease marked by the destruction of pancreatic β‐cells, resulting in lifelong dependence on exogenous insulin. Despite advances in insulin delivery and glucose monitoring technologies, patients remain at risk for acute and long‐term complications, underscoring the need for ...
Tzu‐Min Lin, Hui‐Fang Chang, Tzu‐Ching Lin, Cheng‐Han Lin, Yu‐Ling Sun, Chih‐Sheng Lin   +5 more
wiley   +1 more source

Four Novel HLA-B and HLA-C Alleles Identified in Brazilian Individuals. [PDF]

HLA
Fabreti-Oliveira RA, de Oliveira CKF, Nascimento E.   +2 more
europepmc   +1 more source

Immunological Tolerance: One of Biology's Most Intriguing Mysteries [PDF]

, 1999
Bach FH, Barnard CN, Billingham RE, Calne RY, Calne RY, Carrel A, Dausset J, Demirleau, Derom F, Gatti RA, Gibson T, Goodwin WE, Groth CG, Hamburger J, Kuss R, Lillehei RC, Mazariegos GV, Meeker W, Merrill JP, Moore FD, Moore FD, Murray JE, Owen RD, Przepiorka D, Ramos HC, Schwartz R, Schwartz R, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Starzl TE, Thomas ED, Wessman M, Zinkernagel RM, Zinkernagel RM, Zukoski CF   +48 more
core   +1 more source

Minimal Residual Disease as a Biological Trait: Rethinking Disease Persistence in Hematologic Malignancies

European Journal of Haematology, EarlyView.
ABSTRACT Minimal residual disease (MRD) has emerged as a central biomarker in hematologic malignancies, enabling highly sensitive detection of tumor persistence beyond conventional morphologic assessment and serving as an increasingly important surrogate endpoint in clinical trials.
Santino Caserta, Enrica Antonia Martino, Ernesto Vigna, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Graziella D'Arrigo, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Maria Eugenia Alvaro, Giovanni Tripepi, Fortunato Morabito, Massimo Gentile   +14 more
wiley   +1 more source

Clustering-based identification of immune-related gene signatures in hepatocellular carcinoma. [PDF]

Ecancermedicalscience
Brahmaiah J, Adiga U, Augustine AJ, Vasishta S.   +3 more
europepmc   +1 more source