Results 191 to 200 of about 83,183 (296)

Major histocompatibility complex class II expression on CD14^pos cells in canine peripheral blood across various hematologic disorders-a preliminary study. [PDF]

J Vet Diagn Invest
Martínez-Caro J, Agulla B, Lemos M, Pastor J.   +3 more
europepmc   +1 more source

Haemochromatosis ‐ a modern clinician’s guide

Internal Medicine Journal, EarlyView.
Abstract Haemochromatosis is an inherited disorder of iron metabolism affecting approximately 100 000 Australians. Iron overload may result in end organ dysfunction, most commonly manifesting as chronic liver disease, arthropathy and endocrinopathies. End organ complications can be prevented, minimised or reversed, with early diagnosis and initiation ...
James G. Fiori, John K. Olynyk
wiley   +1 more source

External proficiency testing exercises: challenges and opportunities

Frontiers in Genetics
Ilias Doxiadis, Claudia Lehmann
doaj   +1 more source

Two Distinct Endocrine Conditions in a Single Pediatric Patient: Congenital Adrenal Hyperplasia and Type 1 Diabetes Mellitus. [PDF]

Cureus
Gomes C, Bravo M, Goncalves Marques A, Rosmaninho-Salgado J, Mirante A.   +4 more
europepmc   +1 more source

Mapping malignant T‐cell states and immune circuits in Sézary syndrome by single‐cell analysis

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Peripheral blood single‐cell RNA‐seq from leukaemic CTCL defined three malignant T‐cell programmes: MTC CM, MTC Reg and MTC E/EM, each with distinct features and candidate vulnerabilities. For example, inferred immune circuits highlighted actionable IL‐10/JAK–TYK2–STAT3 signalling, KIR–MHC I inhibitory interactions and myeloid/B‐cell inflammatory and ...
Beth A. Childs, Eslam A. Elghonaimy, Praveen Ramakrishnan Geethakumari, Kiran A. Kumar, Joseph F. Merola, Heather W. Goff, Todd A. Aguilera   +6 more
wiley   +1 more source

Landscapes of HLA Mismatching in Contemporary Unrelated Haematopoietic Cell Transplantation. [PDF]

HLA
Arrieta-Bolaños E, Bonneville EF, Crivello P, Gedde-Dahl T, Peffault de Latour R, Salmenniemi U, Kröger N, Yakoub-Agha I, Zecca M, Choi G, Crawley C, Tholouli E, Dubois V, Peräsaari J, Wieten L, Marsh SGE, Bengtsson M, Hoogenboom JD, Kuball J, Malard F, Ruggeri A, Fleischhauer K.   +21 more
europepmc   +1 more source

Genomic and proteomic insights into hidradenitis suppurativa

Journal of the European Academy of Dermatology and Venereology, EarlyView.
A dual pathogenic model of HS involving both epithelial dysfunction and systemic inflammation is supported. The HLA‐DRA association hints at autoimmune overlap, but the proteomic signature which is dominated by innate immune mediators favours an autoinflammatory classification, which may guide future therapeutic strategies and patient stratification ...
Maria Argyropoulou, Emmanouil Stylianakis, Isis Ricaño‐Ponce, Nick Keur, Theodora Kanni, Dimitra Stergianou, Mihai G. Netea, Vinod Kumar, Evangelos J. Giamarellos‐Bourboulis   +8 more
wiley   +1 more source

Challenges and opportunities in bringing non-HLA antibody testing for post-transplant monitoring. [PDF]

Front Transplant
Philogene MC, Tchoukina I, Gimferrer I.
europepmc   +1 more source

High‐throughput multispecies quantitative polymerase chain reaction assays to study the effects of acute thermal stress in three species of Acipenser sturgeon

Journal of Fish Biology, EarlyView.
Abstract Fishes experience thermal stress in their natural environment that can be caused by natural or anthropogenic factors and can directly affect their physiology. In this study, we developed a multispecies OpenArray™ qPCR (quantitative polymerase chain reaction) ‘chip’ to measure the effects of acute thermal stress on the mRNA response of ...
Hossein Haghighi, Kyle Madden, William S. Bugg, Faith M. Penny, Scott A. Pavey, Nicholas J. Bernier, Kenneth M. Jeffries   +6 more
wiley   +1 more source

Case Report: Atypical extensive orbitofacial tuberculosis extending to the skull base and cavernous sinus revealed major histocompatibility complex class II deficiency in an 11-year-old girl. [PDF]

Front Pediatr
Mezri S, Amri A, Essghaier S, Tlili K, Rabhi M, Marmouri M, Barakizou H.   +6 more
europepmc   +1 more source