Results 191 to 200 of about 753,787 (333)

Histone modifications: Unveiling the epigenetic enigma of degenerative skeletal diseases. [PDF]

open access: yesJ Orthop Translat
Zhang Y   +9 more
europepmc   +1 more source

Lactylation of HMGB1 at K177 Drives Nuclear Export of TIAR to Promote Hypoxia‐Induced Stress Granule Formation

open access: yesAdvanced Science, EarlyView.
This study uncovers a novel mechanism in which p300‑catalyzed lactylation of HMGB1 triggers nuclear export of the HMGB1‐TIAR complex, driving TIAR‐dependent SGs formation in the cytoplasm. Mass spectrometry and mutagenesis reveals that K177 lactylation is essential for this export and subsequent SGs formation.
Chengyu Li   +8 more
wiley   +1 more source

Metabolism of Histones of Brain and Liver

open access: hybrid, 1966
R. S. Piha   +2 more
openalex   +1 more source

Restoring Histone Acetylation Accelerates Diabetic Wound Repair by Improving the Spatiotemporal Dynamics of Macrophages

open access: yesAdvanced Science, EarlyView.
Butyrate—via epigenetic modulation of the histone core—rebalance dysregulated macrophage function and promotes wound healing under persisting hostile conditions of diabetic mice. Additionally, butyrate harmonizes macrophage interactions with keratinocytes and fibroblasts as well as breaks the vicious cycle of inflammation in chronic wounds by restoring
Karmveer Singh   +11 more
wiley   +1 more source

Long non-coding RNAs promote colorectal cancer development through other epigenetic modifications. [PDF]

open access: yesGastroenterol Rep (Oxf)
Wang G   +9 more
europepmc   +1 more source

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