Results 241 to 250 of about 724,595 (331)
Recent Advances in mRNA Delivery Systems for Cancer Therapy
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang+9 more
wiley +1 more source
Protective effect of exercise on metabolic dysfunction‑associated fatty liver disease: Potential epigenetic mechanisms (Review). [PDF]
Zhang Y, Wei Y, Liu H, Guo Y.
europepmc +1 more source
DILUTION OF POLIOVIRUS RIBONUCLEIC ACID AS AN IMPORTANT STEP IN OBTAINING INFECTIVITY WITH HISTONE [PDF]
E. H. Ludwig, Christine E. Smull
openalex +1 more source
The TALENTs randomized controlled trial evaluates the potential of nucleotides supplementation as an anti‐aging intervention in older adults. After 19 weeks, nucleotides supplementation significantly reduces DNA methylation age, suggesting a delay in epigenetic aging, and improves insulin sensitivity without severe adverse events.
Shuyue Wang+9 more
wiley +1 more source
PHF20L1: An Epigenetic Regulator in Cancer and Beyond. [PDF]
Wang Y+10 more
europepmc +1 more source
THE METACHROMATIC INTERACTION OF BIEBRICH SCARLET WITH HISTONE AND OTHER CATIONIC POLYMERS
James W. Winkelman, Samuel S. Spicer
openalex +1 more source
The authors find that by targeting intratumoral copper, they can enhance p62‐mediated ubiquitination of EZH2 at the Ub‐K63 site by suppressing copper binding to SMURF2, an E3 ligase of EZH2, leading to its autophagic degradation. This mechanism suppressed OSCC progression and potentiated anti‐PD‐1 immunotherapy, highlighting a potential new therapeutic
Xiaohu Lin+9 more
wiley +1 more source
Written in chromatin: The enduring legacy of C. David Allis. [PDF]
Strahl BD, Wang GG.
europepmc +1 more source
This study identifies MTCH2 as a crucial regulator of ferroptosis in colorectal cancer (CRC) progression. High expression of MTCH2 is correlated with poor prognosis in CRC patients. Furthermore, MTCH2 depletion induces ferroptosis to suppress CRC liver metastasis via the E2F4/TFRC axis and sensitizes tumors to sorafenib treatment, supporting MTCH2 as a
Pu Xing+18 more
wiley +1 more source