Results 251 to 260 of about 724,595 (331)

Pharmacoepigenetics in schizophrenia: Predicting drug response. [PDF]

World J Psychiatry
Yıldırım SA, Dal I, Özkan-Kotiloğlu S, Baskak B, Kaya-Akyüzlü D.   +4 more
europepmc   +1 more source

Chromatography of histones [PDF]

Biochemical Journal, 1957
openaire   +3 more sources

Accounting for ALA Natural Mutations Enhances the Efficiency of Graphene Oxide Nanopriming in Bar‐Modified Arabidopsis

Advanced Science, EarlyView.
Nanopriming enhances plant resilience to environmental challenges; however, its effectiveness across diverse genetic backgrounds, including genetic modifications and natural variations, remains uncertain. These findings demonstrate that nanopriming improves efficacy when natural genetic variations are considered, particularly in genetically modified ...
Yining Wu, Rui Sun, Yueting Cui, Jun Qiao, Chengdong Zhang   +4 more
wiley   +1 more source

Regulation of plant immunity through histone H3 β-hydroxybutyrylation-mediated transcriptional control. [PDF]

Nat Commun
Xu Q, Chen Z, Wang R, Ma X, Duan Y, Hai D, Chen J, Cheng Z, Zheng L, Huang J, Zhang J, Zhao Y, Chen X.   +12 more
europepmc   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Modulation of histone tail electrostatic potentials in nucleosome core particles by acetylation and PARylation. [PDF]

Proc Natl Acad Sci U S A
Bolik-Coulon N, Rößler P, Nosella ML, Kim TH, Kay LE.   +4 more
europepmc   +1 more source

Nrf2 Drives Epigenetic Reprogramming and Acts as the Master Regulator of KLF4 Expression and Activity in Arsenic‐Induced Transformation

Advanced Science, EarlyView.
Nrf2 isn't just a protector—it's a driver of cancer stemness. The study uncovers how arsenic‐activated Nrf2 directly upregulates KLF4, a key pluripotency factor, fueling oncogenic reprogramming. Through enhancer activation and self‐reinforcing loop, Nrf2 and KLF4 co‐opt gene networks linked to epithelial‐to‐mesenchymal transition and tumor growth ...
Ziwei Wang, Zhuoyue Bi, Jessica Bamrah, Yiran Qiu, Wenxuan Zhang, Bandar Saeed Almutairy, Haoyan Ji, John D. Haley, Chitra Thakur, Fei Chen   +9 more
wiley   +1 more source

A comprehensive review of histone modifications during mammalian oogenesis and early embryo development. [PDF]

Histochem Cell Biol
Bozdemir N, Kablan T, Biyikli E, Cinar O, Uysal F.   +4 more
europepmc   +1 more source

Organization of the Proteostasis Network of Membraneless Organelles

Advanced Science, EarlyView.
A comprehensive mapping of the proteostasis network (PN) across membraneless organelles (MLOs) reveals how central PN components coordinate MLO regulation. The analysis uncovers principles of specificity and promiscuity within the PN. The findings suggest that HSP70 chaperones act as generic MLO regulators, while client specific HSP70 co‐chaperones may
Christine M. Lim, Yuqi Bian, Alicia González Díaz, Frank Pun, Alex Zhavoronkov, Richard I. Morimoto, Michele Vendruscolo   +6 more
wiley   +1 more source

Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetitive elements in early mammalian embryos. [PDF]

Nat Commun
Wang YF, Wan YT, Qi QR, Tian Q, Liu XM, Xie QZ, Yin Y, Zhou LQ.   +7 more
europepmc   +1 more source