Results 251 to 260 of about 753,787 (333)

T2T Genomes Unveil Centromere Architecture and Adaptive Divergence in Large Yellow Croaker (Larimichthys crocea)

Advanced Science, EarlyView.
This study presents telomere‐to‐telomere genome assemblies for two populations of Larimichthys crocea. We identified centromere‐specific tandem repeats invaded by LTR/ERV1 retrotransposons, unique 5S rRNA enrichment patterns, and population‐specific structural variants. Comparative genomic analyses further reveal distinct adaptive mechanisms in the MYD
Yu Cui, Yingbo Yuan, Bi Wang, Baolan Wu, Mingyi Cai, Ming Fang, Weiliang Shen, Xiongfei Wu, Fang Han, Zhiyong Wang   +9 more
wiley   +1 more source

Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors. [PDF]

MedComm (2020)
Zhao L, Cui H, Li Y, Ye Y, Shen Z.
europepmc   +1 more source

THE INTERACTION OF RNA POLYMERASE WITH HISTONES

, 1969
Thomas C. Spelsberg, Sharon Tankersley, Lubomir S. Hnilica   +2 more
openalex   +1 more source

Chromatography of histones [PDF]

Biochemical Journal, 1957
openaire   +3 more sources

ACSS2/AATF Drives Soluble FasL‐Mediated CD8+ T Cell Apoptosis in Pancreatic Neuroendocrine Tumors

Advanced Science, EarlyView.
This study unveils that ACSS2‐driven acetate metabolism fuels histone pan‐acetylation in pancreatic neuroendocrine tumors (PNETs), remodeling the epigenetic landscape. The ACSS2/AATF axis transcriptionally activates soluble FasL (sFasL), which engages Fas receptors on infiltrating CD8+ T cells to trigger caspase‐8/3‐mediated apoptosis.
Qin Dang, Ting Wang, Yan Wang, Zeng Ye, Borui Li, Xuan Pan, Zheng Li, Guixiong Fan, Desheng Jing, Junfeng Xu, Qiangsheng Hu, Shunrong Ji, Xiaowu Xu, Xianjun Yu, Yi Qin   +14 more
wiley   +1 more source

Molecular characterization and clinical features of diffuse midline glioma in the pediatric precision oncology registry INFORM. [PDF]

Acta Neuropathol
Pfaff E, Schramm K, Blattner-Johnson M, Jones BC, Stark S, Balasubramanian GP, Previti C, Autry RJ, Fiesel P, Sahm F, Reuss D, von Deimling A, van Tilburg CM, Pajtler KW, Milde T, Dirksen U, Kramm CM, von Bueren AO, Hutter C, de Wilde B, Molenaar J, Gerber NU, Lohi O, Munthe-Kaas MC, Georgantzi K, Kazanowska B, Zápotocký M, Kattamis A, Filippidou M, Fried I, Pfister SM, Witt O, Jones DTW.   +32 more
europepmc   +1 more source

FGF9–FGFR2 Signaling via Osteocytes‐Preosteoblasts Crosstalks to Mediate Mechanotransduction‐Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla

Advanced Science, EarlyView.
This study identifies osteocyte‐derived FGF9 as a mechanosensitive factor that impairs osteogenesis in the underdeveloped maxilla by inducing FGFR2 nuclear translocation in preosteoblasts. Mechanical stimulation reduces FGF9 secretion, relieving its inhibitory effect. These findings reveal a novel osteocyte–preosteoblast FGF9–FGFR2 axis in craniofacial
Yiwen Zhou, Lili Chen, Miaomiao Han, Peixiang Zhu, Yanyi Wang, Xuanxuan Yu, Tingyu Reng, Huijuan Wang, Baochao Li, Caixia Zhang, Ziwei Huang, Shuang Lin, Guoyun Wang, Jie Ge, Baosheng Guo, Huang Li   +15 more
wiley   +1 more source

SET7/9 exhibits sigmoidal kinetics on nucleosomes, hyperbolic kinetics on histones by an ordered sequential mechanism, and methylates lysine and arginine. [PDF]

J Biol Chem
Ige OO, Hendrickson-Rebizant T, Luo W, Cheung P, Lao Y, Zahedi RP, Davie JR, Lakowski TM.   +7 more
europepmc   +1 more source

METTL10‐Mediated PIAS3 Methylation Links Purine Metabolism to Gastric Cancer Progression

Advanced Science, EarlyView.
METTL10‐mediated methylation of PIAS3 at K442 inhibits its SUMO E3 ligase activity toward MITF. This reduces MITF SUMOylation and subsequent RNF4‐mediated ubiquitination, leading to MITF protein accumulation and gastric cancer progression. Abstract Metabolic dysregulation plays a significant role in the development of gastric cancer (GC).
Jinshui Tan, Huiwen Zhou, Jingsong Ma, Chensong Zhang, Yuhua Tan, Baoding Zhang, Jiabao Zhao, Ao Cheng, Chengyu Yang, Meijuan Xu, Shengyi Zhou, Yubo Xiong, Zeyang Lin, Guangchao Pan, Wenjie Ye, Mengya Zhong, Yang Yang, Yifan Zhuang, Shao‐Wei Li, Xianming Deng, Xuehui Hong   +20 more
wiley   +1 more source

Lactate-mediated histone lactylation promotes melanoma angiogenesis via IL-33/ST2 axis. [PDF]

Cell Death Dis
Zhao M, Qian Y, He L, Peng T, Wang H, Wang X, Jiang L, Fan J, Zhang H, Qu D, Zhu Q, Wang H, Zhang S, Li C, Dong X, Zhao X, Wang H, Yang Y, Yi X, Zhao T, Liu Y, Zhang J, Zhang G, Shi Q, Gao T, Li C, Guo W.   +26 more
europepmc   +1 more source