Results 251 to 260 of about 844,749 (403)

Roles and regulation of histone methylation in animal development

Nature reviews. Molecular cell biology, 2019
A. Jambhekar, A. Dhall, Yang Shi
semanticscholar   +1 more source

Lactylation‐Driven NUPR1 Promotes Immunosuppression of Tumor‐Infiltrating Macrophages in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Cai et al. report that tumor‐derived lactate induces NUPR1 expression via H3K18 lactylation, which can promote the pro‐tumor M2 macrophage polarization through ERK and JNK signaling pathways. Treatment with NUPR1 selective inhibitor sensitizes synergizes with anti‐PD‐1 therapy in murine preclinical models.
Jialiang Cai, Peiling Zhang, Yufan Cai, Guiqi Zhu, Shiping Chen, Lina Song, Junxian Du, Biao Wang, Weixing Dai, Jian Zhou, Jia Fan, Yiyi Yu, Zhi Dai   +12 more
wiley   +1 more source

YEATS2: a novel cancer epigenetic reader and potential therapeutic target. [PDF]

Cancer Cell Int
Ji K, Chen G, Wang Y, Li Y, Chen J, Feng M.   +5 more
europepmc   +1 more source

The Transcriptional Coactivators p300 and CBP Are Histone Acetyltransferases

Cell, 1996
V. Ogryzko, R. Schiltz, V. Russanova, B. Howard, Y. Nakatani   +4 more
semanticscholar   +1 more source

Compilation analysis of histones and histone genes

Nucleic Acids Research, 1986
openaire   +4 more sources

PPY‐Induced iCAFs Cultivate an Immunosuppressive Microenvironment in Pancreatic Cancer

Advanced Science, EarlyView.
Pancreatic ductal adenocarcinoma features abundant stromal components that hinder therapy efficacy. Single‐cell RNA sequencing analysis combined with experiments identified PPY, a gastrointestinal hormone, as a novel inducer of immunosuppressive iCAFs. Mechanistic studies revealed that PPY activates the non‐canonical NF‐κB pathway via EGFR.
Mengdie Cao, Wang Peng, Bin Cheng, Ronghua Wang, Wei Chen, Luyao Liu, Hai Huang, Shiru Chen, Haochen Cui, JingWen Liang, Qiaodan Zhou, Si Xiong, Shuya Bai, Luoxia Liu, Yuchong Zhao   +14 more
wiley   +1 more source

Temporal and spatial distribution of histone acetylation in mouse molar development. [PDF]

PeerJ
Du W, Luo W, Zheng L, Zhou X, Du W.
europepmc   +1 more source

THE EFFECT OF PHYTOHEMAGGLUTININ ON RIBONUCLEIC ACID SYNTHESIS AND HISTONE ACETYLATION IN EQUINE LEUKOCYTES [PDF]

, 1967
Beatriz G.T. Pogo, V. G. Allfrey, A. E. Mirsky   +2 more
openalex   +1 more source

Combinatorial patterns of histone acetylations and methylations in the human genome

Nature Genetics, 2008
Zhibin Wang, C. Zang, J. Rosenfeld, Dustin E. Schones, A. Barski, Suresh Cuddapah, Kairong Cui, Tae-Young Roh, Weiqun Peng, Michael Q. Zhang, K. Zhao   +10 more
semanticscholar   +1 more source

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

Advanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, Ning Zhao, Jianzhong Su, Zhihua Liu, Hongyan Chen   +13 more
wiley   +1 more source