Results 261 to 270 of about 753,787 (333)

Studies on the Heterogeneity and Metabolic Activity of Histones from Rabbit Bone Marrow Cells

, 1963
E.J. Hídvégi, I Árky, F. Antoni, V. Várterész   +3 more
openalex   +1 more source

H3K27ac Is Essential for Human Naive Pluripotency Modulated by m6A‐Driven EP300 Expression

Advanced Science, EarlyView.
An et al. reveal H3K27ac elevation is essential for establishing and maintaining human naive pluripotency; its inhibition disrupts this state while enhancement promotes it. METTL3‐mediated m6A modification indirectly controls H3K27ac by suppressing EP300 expression. Reduced EP300 lowers H3K27ac, impeding naive pluripotency.
Chenrui An, Ke Zhong, Xiangjin Kang, Yingying Zhang, Yudan Shang, Hao Liu, Yushan Ji, Jinbei Zeng, Jiajin Lin, Long Jin, Zelong Lin, Yang Yu, Xuetao Shi, Yong Fan   +13 more
wiley   +1 more source

ARID1A regulates histone octamer transfer activity of human canonical BAF complex. [PDF]

Nucleic Acids Res
Moro N, Fujisawa-Tanaka Y, Watanabe S.
europepmc   +1 more source

Hepatic CBP/p300 Orchestrate Amino Acid‐Driven Gluconeogenesis through Histone Crotonylation

Advanced Science, EarlyView.
Hepatic CBP/p300 control amino acid‐driven gluconeogenesis by modulating histone crotonylation. This study identifies 2‐aminoadipate (2‐AAA) as a key metabolite that enhances crotonylation and activates amino acid and gluconeogenic gene expression.
Chunxiang Sheng, Tianjiao Li, Hong Lin, Xiaoqin Ma, Feiye Zhou, Mingzhu Li, Yiru Wang, Shushu Wang, Jialin Tan, Junmin Chen, Yulin Yang, Jianmin Liu, Yufang Bi, Jieli Lu, Xiao Wang, Libin Zhou   +15 more
wiley   +1 more source

Transforming Cancer Diagnostics: The Emergence of Liquid Biopsy and Epigenetic Markers. [PDF]

MedComm (2020)
Saha D, Kanjilal P, Kaur M, Menon SV, Ashraf A, Kumar MR, Alqahtani T, Atteri S, Uti DE, Dhara B.   +9 more
europepmc   +1 more source

BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation

Advanced Science, EarlyView.
BHLHE40 interacts directly with GATA2 and GATA3 and co‐occupies genomic loci critical for STB differentiation and function. BHLHE40 also affects GATA2/3 binding at enhancer and promoter regions. Moreover, BHLHE40 is potentially involved in genome‐wide remodeling of H3K4me3 and H3K27ac chromatin landscapes through GATA2/3 recruitment, activating ...
Lijin Peng, Weijie Zhao, Chunfang Xu, Yue Li, Jiani Guo, Taotao Zhou, Philip Chiu, Huimei Wu, Qingyu Wu, Yanxing Wei, Shaorong Gao, Meirong Du   +11 more
wiley   +1 more source

Correction: Non-histone lactylation: unveiling its functional significance. [PDF]

Front Cell Dev Biol
Shi P, Ma Y, Zhang S.
europepmc   +1 more source

Calf and Pea Histone IV

, 1969
Robert J. DeLange, Douglas M. Fambrough, Emil L. Smith, James Bonner   +3 more
openalex   +1 more source

Engineering Bacteria as Living Therapeutics in Cancer Therapy

Advanced Science, EarlyView.
Through synthetic biology approaches, natural bacteria can be genetically programmed into multifunctional living therapeutics. These engineered bacteria are capable of secreting anti‐tumor factors, displaying tumor‐associated antigens on their surface, or undergoing programmed self‐lysis to release therapeutic cargo.
Jiangfeng Chen, Jiaqi Chen, Yixuan Chen, Wenxuan Yuan, Jiao Zhang, Guoqing Wang, Zhuojun Dai   +6 more
wiley   +1 more source

Lactylation as a cross-regulatory node in tumor metabolism and epigenetics: insights and therapeutic implications. [PDF]

Front Immunol
Lv Z, Yang R, Liu L, Shi X, Wang R, Wu J, Jiao J.   +6 more
europepmc   +1 more source