SIRT1 retention in elongating spermatids interferes with histone displacement by counteracting MOF-dependent H4K16 acetylation. [PDF]
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Pharmaco-Epigenetics and Epigenetic Drugs in Type 2 Diabetes: Can Epigenetics Predict Drug Efficiency? [PDF]
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Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation. [PDF]
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Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications. [PDF]
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Histone Acetylation and Histone Deacetylation
Molecular Biotechnology, 2002Regulation of inflammatory gene transcription is controlled, at least in part, by the degree of local unwinding of nucleosomal DNA. This unwinding is regulated by histone acetylation--increased acetylation results in a more loosely wound structure allowing access of basal transcription factors and RNA polymerase II.
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Highly specific antibodies were raised to histone 1 (H1) and the histone complexes H3 2 -H4 2 and H2A-H2B, isolated by salt extraction. Antibody to H1 could detect irreversible conformational changes in acid- or urea-treated H1. The antibodies showed different reactivities with chromosomes as
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