Results 301 to 310 of about 844,749 (403)

DNA–Protein Binding is Dominated by Short Anchoring Elements

Advanced Science, EarlyView.
This study delineate the binding mechanism of transcription factors (TFs) in the genome with the knowledge obtained at thermodynamic equilibrium conditions. Through KaScape experiments, combined with the AEEscape algorithm development, they identified the minimal dominant interacting elements, termed as Anchoring Elements (AEs).
Hong Chen, Yongping Xu, Hao Ge, Xiao‐Dong Su   +3 more
wiley   +1 more source

Function of HP1BP3 as a linker histone is regulated by linker histone chaperones, NPM1 and TAF-I. [PDF]

Epigenetics Chromatin
Hisaoka M, Komatsu T, Hashimoto T, Lin J, Ohkawa Y, Okuwaki M.   +5 more
europepmc   +1 more source

The Fractionation of Arginine-rich Histones from Fetal Calf Thymus by Exclusion Chromatography

, 1967
C. M. Mauritzen, Wesley C. Starbuck, Iengar S. Saroja, Charles W. Taylor, Harris Busch   +4 more
openalex   +1 more source

Inhibiting the Histone Demethylase Kdm4a Restrains Cardiac Fibrosis After Myocardial Infarction by Promoting Autophagy in Premature Senescent Fibroblasts

Advanced Science, EarlyView.
Kdm4a downregulation restrains excessive cardiac interstitial fibrosis and remodeling by depressing the premature senescence of fibroblasts in the advanced stage after MI but does not affect early ventricular rupture. It verified that Kdm4a downregulation promotes autophagy in premature senescent fibroblasts by increasing the H3K9m3 modification of the
Ming Jin, Chuling Li, Zhaoyi Wu, Zhenquan Tang, Jingfang Xie, Guoquan Wei, Zhiwen Yang, Senlin Huang, Yijin Chen, Xinzhong Li, Yanmei Chen, Wangjun Liao, Yulin Liao, Guojun Chen, Hao Zheng, Jianping Bin   +15 more
wiley   +1 more source

Histone bivalency in CNS development. [PDF]

Genes Dev
Mätlik K, Govek EE, Hatten ME.
europepmc   +1 more source

Histone methylation: a dynamic mark in health, disease and inheritance

Nature reviews genetics, 2012
E. L. Greer, Yang Shi
semanticscholar   +1 more source

Neuronal C/EBPβ Shortens the Lifespan via Inactivating NAMPT

Advanced Science, EarlyView.
Schematic diagram illustrating the mechanism of shortened lifespan in Thy 1‐C/EBPβ transgenic mice and intervention strategies. Briefly, C/EBPβ/AEP escalation in the aging brain triggers NAMPT fragmentation and NAD+ depletion. Knockout of AEP from Thy 1‐C/EBPβ Tg/Tg mice ameliorates cognitive impairments and elongates the lifespan.
Bowei Li, Zhongyun Xie, Mengmeng Wang, Shuke Nie, Zhengjiang Qian, Xin Meng, Xia Liu, Seong Su Kang, Keqiang Ye   +8 more
wiley   +1 more source

The Effects of Histones and Other Polycations on Cellular Energetics

, 1965
Arnold Schwartz
openalex   +1 more source

Unraveling Neurodevelopment: Synergistic Effects of Intrinsic Genetic Programs and Extrinsic Environmental Cues

Advanced Science, EarlyView.
Overview of the regulation of intrinsic and extrinsic signals during neurodevelopment. Intrinsic genetic signals from NSCs, in conjunction with cues from microglia and blood vessels, collaboratively regulate the proliferation of NSCs, their fate determination, synaptogenesis, synaptic pruning, neuronal survival, and death, as well as communication ...
Yanyan Wang, Shukui Zhang, Huiyang Jia, Fen Ji, Jianwei Jiao   +4 more
wiley   +1 more source

Tip60 HAT activators as therapeutic modulators for Alzheimer's disease. [PDF]

Nat Commun
Bhatnagar A, Thomas CM, Nge GG, Zaya A, Dasari R, Chongtham N, Manandhar B, Kortagere S, Elefant F.   +8 more
europepmc   +1 more source