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SIRT1 retention in elongating spermatids interferes with histone displacement by counteracting MOF-dependent H4K16 acetylation. [PDF]

open access: yesFront Cell Dev Biol
Porreca V   +12 more
europepmc   +1 more source

Protamine expression in somatic cells condenses chromatin and disrupts transcription without altering DNA methylation. [PDF]

open access: yesEpigenetics Chromatin
Puri D   +6 more
europepmc   +1 more source

Epigenetics in pharmacogenes encoding metabolizing enzymes of second-generation antipsychotics used in schizophrenia and its clinical implications. [PDF]

open access: yesFront Pharmacol
Alvarado AT   +12 more
europepmc   +1 more source

Sulforaphane from broccoli, an epigenetic modulator in cancer cells. [PDF]

open access: yesDiscov Oncol
Dabre S   +7 more
europepmc   +1 more source

Engineered histones reshape chromatin in human cells

open access: yes
Jena SG   +9 more
europepmc   +1 more source
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Histone Acetylation and Histone Deacetylation

Molecular Biotechnology, 2002
Regulation of inflammatory gene transcription is controlled, at least in part, by the degree of local unwinding of nucleosomal DNA. This unwinding is regulated by histone acetylation--increased acetylation results in a more loosely wound structure allowing access of basal transcription factors and RNA polymerase II.
Kazuhiro Ito, Ian M. Adcock
openaire   +2 more sources

Antibodies to Histones and Histone-Histone Complexes: Immunochemical Evidence for Secondary Structure in Histone 1

Science, 1976
Highly specific antibodies were raised to histone 1 (H1) and the histone complexes H3 2 -H4 2 and H2A-H2B, isolated by salt extraction. Antibody to H1 could detect irreversible conformational changes in acid- or urea-treated H1. The antibodies showed different reactivities with chromosomes as
Orlando J. Miller   +2 more
openaire   +3 more sources

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