Results 71 to 80 of about 570,523 (273)
Mapping Dynamic Histone Acetylation Patterns to Gene Expression in Nanog-depleted Murine Embryonic Stem Cells [PDF]
PLoS Comp Bio, 2010 Dec 16;6(12):e1001034, 2010 Embryonic stem cells (ESC) have the potential to self-renew indefinitely and to differentiate into any of the three germ layers. The molecular mechanisms for self-renewal, maintenance of pluripotency and lineage specification are poorly understood, but recent results point to a key role for epigenetic mechanisms.
arxiv +1 more source
The Roles of Histone Deacetylases and Their Inhibitors in Cancer Therapy
Frontiers in Cell and Developmental Biology, 2020 Genetic mutations and abnormal gene regulation are key mechanisms underlying tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores, represent the basic units of chromatin. The fifth amino group (Nε) of histone lysine residues is a
Guo Li, Yuan Tian, Wei-Guo Zhu
semanticscholar +1 more source
Study of histone—histone interactions by affinity chromatography [PDF]
FEBS Letters, 1974 The structure and the function of the chromatin are de~nding upon the interactions between its major components: DNA, histones and non-h&one proteins (NHP). Histones and probably NHP are known to interact with DNA at least by electrostatic binding. But little is known about protein-protein interactions.
Gérard Biserte +4 more
openaire +3 more sources
Dissecting Nucleosome Function with a Comprehensive Histone H2A and H2B Mutant Library
G3: Genes, Genomes, Genetics, 2017 Using a comprehensive library of histone H2A and H2B mutants, we assessed the biological function of each amino acid residue involved in various stress conditions including exposure to different DNA damage-inducing reagents, different growth temperatures,
Shuangying Jiang +8 more
doaj +1 more source
Frontiers in Microbiology, 2019 Understanding of the molecular responses underpinning diatom responses to ocean acidification is fundamental for predicting how important primary producers will be shaped by the continuous rise in atmospheric CO2.
Ruiping Huang +7 more
doaj +1 more source
Constraints, Histones, and the 30 Nanometer Spiral [PDF]
, 2001 We investigate the mechanical stability of a segment of DNA wrapped around a histone in the nucleosome configuration. The assumption underlying this investigation is that the proper model for this packaging arrangement is that of an elastic rod that is free to twist and that writhes subject to mechanical constraints.
arxiv +1 more source
Epigenetic Regulation of Autophagy: A Path to the Control of Autoimmunity
Frontiers in Immunology, 2018 Autoimmune diseases are a significant cause of debilitation and mortality globally and are in need of cost-effective therapeutics. Autophagy is a cellular pathway that facilitates immune modulation involved in both pathogen control and autoimmunity ...
Jessica C. Hargarten +1 more
doaj +1 more source
Writing, erasing and reading histone lysine methylations
Experimental &Molecular Medicine, 2017 Histone modifications are key epigenetic regulatory features that have important roles in many cellular events. Lysine methylations mark various sites on the tail and globular domains of histones and their levels are precisely balanced by the action of ...
K. Hyun +3 more
semanticscholar +1 more source
On the origin of the histone fold [PDF]
BMC Structural Biology, 2007 AbstractBackgroundHistones organize the genomic DNA of eukaryotes into chromatin. The four core histone subunits consist of two consecutive helix-strand-helix motifs and are interleaved into heterodimers with a unique fold. We have searched for the evolutionary origin of this fold using sequence and structure comparisons, based on the hypothesis that ...
Alva, Vikram +3 more
openaire +5 more sources
Frontiers in Endocrinology, 2018 Gonadotropin-releasing hormone (GnRH) stimulates the expression of multiple genes in the pituitary gonadotropes, most notably to induce synthesis of the gonadotropins, luteinizing hormone (LH), and follicle-stimulating hormone (FSH), but also to ensure ...
Philippa Melamed +6 more
doaj +1 more source