Results 71 to 80 of about 724,595 (331)

Circulating histones as clinical biomarkers in critically ill conditions

FEBS Letters, EarlyView.
Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez, Juan Carlos Ruiz‐Rodríguez, Ricard Ferrer, Raquel Durá, Antonio Artigas, Iván Bajaña, David Bolado López de Andujar, Irene Cánovas‐Cervera, Adrián Ceccato, Luis Chiscano‐Camón, Elena Climent‐Martinez, Georgia García Fernández, Gemma Goma, Verónica Monforte, Beatriz Quevedo‐Sánchez, Adolf Ruiz‐Sanmartín, Antonio Sierra‐Rivera, Nieves Carbonell Monleón   +17 more
wiley   +1 more source

A length-dynamic Tonks gas theory of histone isotherms

, 2002
We find exact solutions to a new one-dimensional (1D) interacting particle theory and apply the results to the adsorption and wrapping of polymers (such as DNA) around protein particles (such as histones).
Marko J. F., Piasecki J., Poland D., Sinden R. R., Thompson C., Tom Chou, Vilfan A., Vilfan A., Widom J.   +8 more
core   +1 more source

MicroRNAs as new Characters in the Plot between Epigenetics and Prostate Cancer

Frontiers in Genetics, 2011
Prostate cancer (PCA) still represents a leading cause of death. An increasing number of studies have documented that microRNAs (miRNAs), a subgroup of non-coding RNAs with gene regulatory functions, are differentially expressed in PCA respect to the ...
Alessio ePaone, Roberta eGalli, Muller eFabbri   +2 more
doaj   +1 more source

First report of root and crown rot caused by Dactylonectria novozelandica on strawberry in Uruguay

Agrociencia Uruguay, 2022
Since 2015, a high mortality rate of strawberry plants has been observed in the north of Uruguay related to crown and root diseases caused by a pathogens complex. In 2016, associated with the death of plants, Cylindrocarpon spp.
Micaela Vigliecca, Pablo González, Alex Machín, Esteban Vicente, Elisa Silvera   +4 more
doaj   +1 more source

Structural basis for the Rad6 activation by the Bre1 N-terminal domain

eLife, 2023
The mono-ubiquitination of the histone protein H2B (H2Bub1) is a highly conserved histone post-translational modification that plays critical roles in many fundamental processes. In yeast, this modification is catalyzed by the conserved Bre1–Rad6 complex.
Meng Shi, Jiaqi Zhao, Simin Zhang, Wei Huang, Mengfei Li, Xue Bai, Wenxue Zhang, Kai Zhang, Xuefeng Chen, Song Xiang   +9 more
doaj   +1 more source

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Interaction of the 89K murine cytomegalovirus immediate-early protein with core histones [PDF]

, 1988
The conditions that permit the interaction of immediate-early proteins of murine cytornegalovirus (MCMV) with DNA were studied. Chromatography of extracts from infected cells on MCMV DNA cellulose and calf thymus DNA cellulose showed that pp89, the ...
Alberts, Bookout, Ebeling, Einck, Everett, Faber, Freeman, Green, Günther M. Keil, Hay, Hermiston, Isenberg, Kedes, Keil, Keil, Keil, Keil, Konrad Munch, Koszinowski, Koszinowski, Koszinowski, Kristie, Kristie, Martin Messerle, O'Hare, Ohlenbusch, Purifoy, Reddehase, Rigby, Stein, Tevethia, Ulrich H. Koszinowski, Weissbach   +32 more
core   +1 more source

DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation

Cell Reports, 2021
Summary: Histone lysine methylation functions at the interface of the extracellular environment and intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known ...
Tanjing Song, Qingli Zou, Yingying Yan, Suli Lv, Neng Li, Xuefeng Zhao, Xianyun Ma, Haigang Liu, Borui Tang, Lidong Sun   +9 more
doaj  

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Methylated DNMT1 and E2F1 Are Targeted for Proteolysis by L3MBTL3 and CRL4DCAF5 Ubiquitin Ligase [PDF]

, 2018
Many non-histone proteins are lysine methylated and a novel function of this modification is to trigger the proteolysis of methylated proteins. Here, we report that the methylated lysine 142 of DNMT1, a major DNA methyltransferase that preserves ...
Alejo, Salvador, Hoang, Nam, Leng, Feng, Lu, Fei, Sun, Hong, Yu, Jiekai, Zhang, Chunxiao, Zhang, Hui   +7 more
core   +3 more sources