Results 101 to 110 of about 56,937 (264)
Ectopic application of the repressive histone modification H3K9me2 establishes post-zygotic reproductive isolation in Arabidopsis thaliana [PDF]
, 2017 Hybrid seed lethality as a consequence of interspecies or interploidy hybridizations is a major mechanism of reproductive isolation in plants. This mechanism is manifested in the endosperm, a dosage-sensitive tissue supporting embryo growth.
De Jaeger, Geert +6 more
core +1 more source
Conservation of centromeric histone 3 interaction partners in plants [PDF]
, 2020 The loading and maintenance of centromeric histone 3 (CENH3) at the centromere are critical processes ensuring appropriate kinetochore establishment and equivalent segregation of the homologous chromosomes during cell division.
Geelen, Danny +3 more
core +1 more source
Histone H3-K56 Acetylation Is Catalyzed by Histone Chaperone-Dependent Complexes [PDF]
Molecular Cell, 2007 Acetylation of histone H3 on lysine 56 occurs during mitotic and meiotic S phase in fungal species. This acetylation blocks a direct electrostatic interaction between histone H3 and nucleosomal DNA, and the absence of this modification is associated with extreme sensitivity to genotoxic agents.
Tsubota, Toshiaki +7 more
openaire +3 more sources
Animal Models and Experimental Medicine, EarlyView.This narrative review discusses animal models of exosome‐based myocardial infarction treatments. Emerging techniques aim to improve exosome stability, targeting, and bioavailability for MI treatment as drug delivery vehicles and regenerative mediators that promote myocardial regeneration. Abstract Exosomes have emerged as promising therapeutic carriers,
Chayanisa Phutiyothin +2 more
wiley +1 more source
In vivo Study of the Histone Chaperone Activity of Nucleolin by FRAP
Biochemistry Research International, 2011 Nucleolin is a major nucleolar protein involved in various aspects of ribosome biogenesis such as regulation of polymerase I transcription, pre-RNA maturation, and ribosome assembly.
Xavier Gaume +4 more
doaj +1 more source
Nature Communications, 2023 Here the authors investigated the direct collaboration between ubiquitinated histone H2B (ubH2B) with FACT at the nucleosome level. They found ubH2B enhances FACT’s chaperone property, recruits FACT to form a stable altered nucleosome state, and provides
Anfeng Luo +10 more
doaj +1 more source
DNA Repair Factor APLF Is a Histone Chaperone [PDF]
Molecular Cell, 2011 Poly(ADP-ribosyl)ation plays a major role in DNA repair, where it regulates chromatin relaxation as one of the critical events in the repair process. However, the molecular mechanism by which poly(ADP-ribose) modulates chromatin remains poorly understood.
Mehrotra, Pawan Vinod +7 more
openaire +4 more sources
Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy
BMEMat, EarlyView.Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu +5 more
wiley +1 more source
How two become one: HJURP dimerization drives CENP-A assembly [PDF]
, 2013 CENP‐A containing nucleosomes epigenetically specify centromere position on chromosomes. Deposition of CENP‐A into chromatin is mediated by HJURP, a specific CENP‐A chaperone. Paradoxically, HJURP binding sterically prevents dimerization of CENP‐A, which
Bodor, Dani L, Jansen, Lars E T
core +1 more source
Histone Chaperones Nap1 and Vps75 Regulate Histone Acetylation during Transcription Elongation [PDF]
Molecular and Cellular Biology, 2013 Histone chaperones function in chromatin assembly and disassembly, suggesting they have important regulatory roles in transcription elongation. The Saccharomyces cerevisiae proteins Nap1 and Vps75 are structurally related, evolutionarily conserved histone chaperones.
Yu-Ming, Xue +6 more
openaire +2 more sources