Results 111 to 120 of about 31,902 (257)

Structural insights into histone chaperone Chz1-mediated H2A.Z recognition and histone replacement.

PLoS Biology, 2019
Chz1 is a specific chaperone for the histone variant H2A.Z in budding yeast. The ternary complex formed by Chz1 and H2A.Z-H2B dimer is the major in vivo substrate of Swi2/snif2-related 1 (SWR1), the ATP-dependent chromatin remodeling enzyme that deposits
Yunyun Wang, Sheng Liu, Lu Sun, Ning Xu, Shan Shan, Fei Wu, Xiaoping Liang, Yingzi Huang, Ed Luk, Carl Wu, Zheng Zhou   +10 more
doaj   +1 more source

Purification of Advanced Therapeutics by Flow‐Through Pseudo‐Affinity Chromatography: Bi‐Specific mABs, Fc Fusion Proteins, and Adeno‐Associated Viruses

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Modern biopharmaceutical manufacturing requires purification platforms capable of processing structurally and functionally diverse products while addressing the challenge of removing persistent and high‐risk host cell proteins (HCPs).
Wenning Chu, Eduardo Barbieri, Arianna Minzoni, Shriarjun Shastry, Jacob P. LeBarre, Qingbo Shu, Taufika Williams, Xuanwen Li, Divya Chandra, Xuankuo Xu, Jerome Bill, David Roush, Joseph Taris, Patrick Gilbert, Andre Kiesewetter, Oliver Rammo, Michael Schulte, Christopher Major, Trina Mouchahoir, Steven Cramer, Cristiana Boi, Ruben G. Carbonell, Abraham Lenhoff, Stefano Menegatti   +23 more
wiley   +1 more source

Molecular functions of the histone acetyltransferase chaperone complex [PDF]

, 2008
Histone acetylation and nucleosome remodeling regulate DNA damage repair, replication and transcription. Rtt109, a recently discovered histone acetyltransferase (HAT) from Saccharomyces cerevisiae, functions with the histone chaperone Asf1 to acetylate ...
Susan Lee, John M Denu, James M, Paul D Kaufman, Toshiaki Tsubota, James L Keck, Scott E Lindner, Christopher E Berndsen   +7 more
core  

H3K56me3 is a novel, conserved heterochromatic mark that largely but not completely overlaps with H3K9me3 in both regulation and localization. [PDF]

, 2013
Histone lysine (K) methylation has been shown to play a fundamental role in modulating chromatin architecture and regulation of gene expression. Here we report on the identification of histone H3K56, located at the pivotal, nucleosome DNA entry/exit ...
Pünzeler, Sebastian, Sebastian Pünzeler (381339), Gunnar Schotta (116394), Jack, Antonia P. M., Michael Wells (381341), Bussemer, Silva, Martha Snyder (381340), Hake, Sandra B., Matthias Hahn, Irina Solovei, Solovei, Irina, Hahn, Matthias, Wells, Michael, Gunnar Schotta, Sebastian Pünzeler, Martha Snyder, Sandra B. Hake (165089), Matthias Hahn (209009), Antonia P. M. Jack (381337), Irina Solovei (85), Sandra B Hake, Silva Bussemer, Michael Wells, Antonia P M Jack, Silva Bussemer (381338), Gyorgyi Csankovszki (5654086), Snyder, Martha, Schotta, Gunnar, Csankovszki, Gyorgyi, Gyorgyi Csankovszki   +29 more
core   +1 more source

Harnessing ferroptosis from multilayer defense networks to nanoplatforms for specific cancer therapy

BMEMat, EarlyView.
Nanomaterials target metabolically‐regulated ferroptosis for cancer therapy. Iron‐based or alternative nanoplatforms integrate ferroptosis with chemotherapy, immunotherapy, or radiotherapy. They enable stimulus‐responsive therapies (photothermal, photodynamic, sonodynamic) activated by near‐infrared, light, or ultrasound, achieving potent synergistic ...
Xinyue Xu, Xuejian Wang, Wenyan Jiang, Wan Hairul Anuar Kamaruddin, Chunyan Fang, Pengfei Zhang   +5 more
wiley   +1 more source

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3 [PDF]

, 2016
Anti-silencing function 1 (ASF1) is a histone H3-H4 chaperone involved in DNA replication and repair, and transcriptional regulation. Here, we identify ASF1B, the mammalian paralog to ASF1, as a proliferation-inducing histone chaperone in human β-cells ...
Peter W. Lewis (1337268), Mary E. Rabaglia (113055), Alan D. Attie (42426), Christina Kendziorski (42423), Mark P. Keller (42421), Ning Leng (386645), Pradyut K. Paul (3224484), Chen-Yu Wang (435114), Donald S. Stapleton (201995)   +8 more
core   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

Prognostic value of histone chaperone FACT subunits expression in breast cancer [PDF]

, 2017
Kristopher Attwood,1 Daria Fleyshman,2 Laura Prendergast,2 Geraldine Paszkiewicz,2 Angela R Omilian,3 Wiam Bshara,3 Katerina Gurova2 1Department of Biostatistics and Bioinformatics, 2Department of Cell Stress Biology, 3Department of Pathology, Roswell ...
Prendergast L, Omilian AR, Attwood K, Gurova K, Fleyshman D, Bshara W, Paszkiewicz G   +6 more
core  

A Quantitative Characterization of Nucleoplasmin/Histone Complexes Reveals Chaperone Versatility. [PDF]

, 2016
Nucleoplasmin (NP) is an abundant histone chaperone in vertebrate oocytes and embryos involved in storing and releasing maternal histones to establish and maintain the zygotic epigenome. NP has been considered a H2A-H2B histone chaperone, and recently it
Alonso, E., Muga, A., Alonso, E, Fernández-Rivero, Noelia, Franco, Aitor, Franco, A., Alonso, Edurne, Prado, A., Muga, A, Velázquez-Campoy, A., Velázquez-Campoy, A, Muga, Arturo, Velázquez-Campoy, Adrián, Fernández-Rivero, N., Fernández-Rivero, N, Franco, A, Prado, A, Prado, Adelina   +17 more
core   +1 more source