Results 111 to 120 of about 31,898 (266)

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

The chaperone-histone partnership: for the greater good of histone traffic and chromatin plasticity

, 2011
Histones are highly positively charged proteins that wrap our genome. Their surface properties also make them prone to nonspecific interactions and aggregation.
Ladurner, Andreas G., Andreas G Ladurner, Hondele, Maria, Maria Hondele   +3 more
core   +1 more source

Post‐Translational Modifications of Key Proteins in Hematologic Malignancies: Carcinogenic Mechanisms, Biomarker Potential, and New Therapeutic Strategies

iLABMED, EarlyView.
This article reviews the pivotal role of post‐translational modifications of proteins in the development and progression of hematologic malignancies, and explores their clinical translation potential as novel biomarkers and therapeutic targets. ABSTRACT Post‐translational modifications (PTMs) of proteins have emerged as critical regulators in the ...
Yuxuan Han, Chaowei Zhang, Weiyi Yao, Qing Hong, Xinyu Tang, Yanan Zhu, Na Chen   +6 more
wiley   +1 more source

Histone chaperones: Variety and functions

Moscow University Biological Sciences Bulletin, 2016
Histone chaperones are required for the formation of the nucleosome—the basic unit of chromatin that consists of the DNA and histones. In this review, participation of histone chaperones CAF-1, ASF1, NAP1, and FACT in key cellular processes is discussed.
M. E. Valieva, A. V. Feofanov, V. M. Studitsky   +2 more
openaire   +2 more sources

The Multifunctional Protein Nucleophosmin (NPM1) Is a Human Linker Histone H1 Chaperone

, 2011
Linker histone H1 plays an essential role in chromatin organization. Proper deposition of linker histone H1 as well as its removal is essential for chromatin dynamics and function.
Sajad Hussain Syed, P. Senapati, R.E. Rajan, Venkatesh Swaminathan, Tapas K. Kundu, P.G. Pelicci, Roshan Elizabeth Rajan, S. Dimitrov, Parijat Senapati, Stefan Dimitrov, T. K. Kundu T.K., V. Swaminathan, Shrikanth S. Gadad, S.S. Gadad, Pier Giuseppe Pelicci, Udaykumar Ranga, Jayasha Shandilya, S.H. Syed, S. Chatterjee, E. Colombo, Emanuela Colombo, Snehajyoti Chatterjee, U. Ranga, J. Shandilya   +23 more
core   +1 more source

A Quantitative Characterization of Nucleoplasmin/Histone Complexes Reveals Chaperone Versatility. [PDF]

, 2016
Nucleoplasmin (NP) is an abundant histone chaperone in vertebrate oocytes and embryos involved in storing and releasing maternal histones to establish and maintain the zygotic epigenome. NP has been considered a H2A-H2B histone chaperone, and recently it
Alonso, E., Muga, A., Alonso, E, Fernández-Rivero, Noelia, Franco, Aitor, Franco, A., Alonso, Edurne, Prado, A., Muga, A, Velázquez-Campoy, A., Velázquez-Campoy, A, Muga, Arturo, Velázquez-Campoy, Adrián, Fernández-Rivero, N., Fernández-Rivero, N, Franco, A, Prado, A, Prado, Adelina   +17 more
core   +1 more source

Salt‐induced nutritional and metabolic shifts in halophytes: implications for food security

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Plant species vary in their response to salinity: some crops show a degree of salt tolerance, while halophytes – whether wild or cultivated – are characterized by a high capacity to thrive under saline conditions. Halophytes are considered a source of valuable secondary metabolites with potential economic value, yet they might also produce ...
Giulia Atzori, Pedro Garcia Caparros, Antonella Castagna, Luisa Custódio, Valentina Lazazzara, Claus Krogh Madsen, Felicia Menicucci, Maria João Rodrigues, Katalin Solymosi, Jose Ramon Acosta Motos   +9 more
wiley   +1 more source

The Multifunctional Protein Nucleophosmin (NPM1) Is a Human Linker Histone H1 Chaperone

, 2016
Linker histone H1 plays an essential role in chromatin organization. Proper deposition of linker histone H1 as well as its removal is essential for chromatin dynamics and function.
Tapas K. Kundu (382662), Sajad Hussain Syed (2211199), Jayasha Shandilya (382659), Snehajyoti Chatterjee (382661), Parijat Senapati (382660), Pier Giuseppe Pelicci (268773), Emanuela Colombo (2211193), Shrikanth S. Gadad (2211190), Stefan Dimitrov (463330), Udaykumar Ranga (317403), Venkatesh Swaminathan (2211187), Roshan Elizabeth Rajan (2211196)   +11 more
core   +1 more source

Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity [PDF]

, 2017
The HIRA histone chaperone complex deposits histone H3.3 into nucleosomes in a DNA replication- and sequence-independent manner. As herpesvirus genomes enter the nucleus as naked DNA, we asked whether the HIRA chaperone complex affects herpesvirus ...
Brock, Claire, Adams, Peter D., Rather, Mohammad, Taranjit Singh Rai, Claire Brock, Marsden, Morgan, Roger D. Everett, Mandy Glass, Matthew Neilson, Peter D. Adams, Glass, Mandy, Rai, Taranjit Singh, Cole, John J., Rather, Mohammad I., Morgan Marsden, Neilson, Matthew, Ian R. Humphreys, John J. Cole, Mohammad I. Rather, Everett, Roger D., Humphreys, Ian R.   +20 more
core   +1 more source

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source