Results 121 to 130 of about 31,902 (257)

Histone chaperones: Variety and functions

Moscow University Biological Sciences Bulletin, 2016
Histone chaperones are required for the formation of the nucleosome—the basic unit of chromatin that consists of the DNA and histones. In this review, participation of histone chaperones CAF-1, ASF1, NAP1, and FACT in key cellular processes is discussed.
M. E. Valieva, A. V. Feofanov, V. M. Studitsky   +2 more
openaire   +2 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Histone chaperone HIRA deposits histone H3.3 onto foreign viral DNA and contributes to anti-viral intrinsic immunity [PDF]

, 2017
The HIRA histone chaperone complex deposits histone H3.3 into nucleosomes in a DNA replication- and sequence-independent manner. As herpesvirus genomes enter the nucleus as naked DNA, we asked whether the HIRA chaperone complex affects herpesvirus ...
Brock, Claire, Adams, Peter D., Rather, Mohammad, Taranjit Singh Rai, Claire Brock, Marsden, Morgan, Roger D. Everett, Mandy Glass, Matthew Neilson, Peter D. Adams, Glass, Mandy, Rai, Taranjit Singh, Cole, John J., Rather, Mohammad I., Morgan Marsden, Neilson, Matthew, Ian R. Humphreys, John J. Cole, Mohammad I. Rather, Everett, Roger D., Humphreys, Ian R.   +20 more
core   +1 more source

Histone binding of ASF1 is required for fruiting body development but not for genome stability in the filamentous fungus Sordaria macrospora

mBio
The highly conserved eukaryotic histone chaperone ASF1 is involved in the assembly and disassembly of nucleosomes during transcription, DNA replication, and repair. It was the first chaperone discovered to be involved in all three of these processes. The
Jan Breuer, Tobias Busche, Jörn Kalinowski, Minou Nowrousian   +3 more
doaj   +1 more source

Maintenance of cell fates and regulation of the histone variant H3.3 by TLK kinase in Caenorhabditis elegans

Biology Open, 2019
Cell-fate maintenance is important to preserve the variety of cell types that are essential for the formation and function of tissues. We previously showed that the acetylated histone-binding protein BET-1 maintains cell fate by recruiting the histone ...
Yukimasa Shibata, Yoshiyuki Seki, Kiyoji Nishiwaki   +2 more
doaj   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone [PDF]

, 2001
We previously identified and purified a nucleolar phosphoprotein, nucleophosmin/B23, as a stimulatory factor for replication from the adenovirus chromatin. We show here that nucleophosmin/B23 functions as a histone chaperone protein such as nucleoplasmin,
Matsumoto, Ken, Tsujimoto, Masafumi, Ken Matsumoto, Nagata, Kyosuke, Masafumi Tsujimoto, Kyosuke Nagata, Okuwaki, Mitsuru, Mitsuru Okuwaki   +7 more
core   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Regulation of histone acetylation and turnover by histone chaperones

The FASEB Journal, 2009
Acetylation of histone H3 on lysine 56 occurs on newly synthesized histones in fungal species, and the absence of this modification is associated with extreme sensitivity to genotoxic agents. H3‐K56 acetylation is catalyzed when Rtt109, a distant homolog of p300/CBP acetyltransferases, is stimulated by either ...
openaire   +1 more source

Histone chaperone Nap1 facilitates histone dynamics in the nucleosome

The FASEB Journal, 2018
We developed a single‐molecule FRET (smFRET) experimental system with which we can separately monitor histone H2A‐H2B dimer dynamics and DNA dynamics within a nucleosome particle. Utilizing the system, we monitored the nucleosome dynamics in the presence of histone chaperone Nap1 in order to investigate how the chaperone alters the dynamics of the ...
Tae‐Hee Lee, Jaehyoun Lee
openaire   +1 more source