Results 141 to 150 of about 56,937 (264)

The Role of the MCM2-7 Helicase Subunit MCM2 in Epigenetic Inheritance

Biology
Recycling histone proteins from parental chromatin, a process known as parental histone transfer, is an important component in chromosome replication and is essential for epigenetic inheritance.
Jing Jia, Chuanhe Yu
doaj   +1 more source

Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response

Nature Communications, 2019
The autophagy protein p62 undergoes liquid-liquid phase separation but how this is regulated is unclear. Here, the authors report that the histone chaperone DAXX interacts with p62 in the cytoplasm to drive its phase separation.
Yi Yang, Thea L. Willis, Robert W. Button, Conor J. Strang, Yuhua Fu, Xue Wen, Portia R. C. Grayson, Tracey Evans, Rebecca J. Sipthorpe, Sheridan L. Roberts, Bing Hu, Jianke Zhang, Boxun Lu, Shouqing Luo   +13 more
doaj   +1 more source

Decoding stress resilience in soybean: Regulatory networks and precision breeding under climate change

Journal of Integrative Plant Biology, EarlyView.
This review covers recent progress in the understanding of stress‐responsive regulatory networks in soybean and highlights emerging genomic and breeding strategies. Integrating molecular insights and precision breeding will help to accelerate the development of climate‐resilient soybean cultivars.
Ali Shahzad, Monan Sun, Shuangkang Pei, Xiaoyu Liu, Yinhe Zhang, Keheng Xu, Hongtao Gao, Yonggang Zhou, Haiyan Li   +8 more
wiley   +1 more source

A long non-coding RNA is required for targeting centromeric protein A to the human centromere

eLife, 2014
The centromere is a specialized chromatin region marked by the histone H3 variant CENP-A. Although active centromeric transcription has been documented for over a decade, the role of centromeric transcription or transcripts has been elusive.
Delphine Quénet, Yamini Dalal
doaj   +1 more source

Autoimmunity and Periodontitis

Journal of Periodontal Research, EarlyView.
In a microbe‐driven inflammatory environment, peptidyl‐arginine deiminase (PAD) enzymes from neutrophils and Porphyromonas gingivalis citrullinate both microbial and self‐antigens. B cell presentation of citrullinated or self‐mimicking epitopes activates T cells that assist B cells in antibody isotype switching, affinity maturation, epitope spreading ...
Massimo Costalonga, Vivek Thumbigere‐Math, Mark C. Herzberg   +2 more
wiley   +1 more source

Imaging the fate of histone Cse4 reveals de novo replacement in S phase and subsequent stable residence at centromeres

eLife, 2014
The budding yeast centromere contains Cse4, a specialized histone H3 variant. Fluorescence pulse-chase analysis of an internally tagged Cse4 reveals that it is replaced with newly synthesized molecules in S phase, remaining stably associated with ...
Jan Wisniewski, Bassam Hajj, Jiji Chen, Gaku Mizuguchi, Hua Xiao, Debbie Wei, Maxime Dahan, Carl Wu   +7 more
doaj   +1 more source

Hydrogen Gas Enhances Salinity Tolerance in Tomato Seedlings by Regulating the S‐Nitrosylation of MEK1

Plant Biotechnology Journal, EarlyView.
ABSTRACT Hydrogen gas (H2) effectively alleviates abiotic stress in horticultural plants. Protein S‐nitrosylation, a key post‐translational modification, serves as a critical mechanism for nitric oxide (NO) to exert its biological function under adverse conditions.
Hua Fang, Xuetong Wu, Dengjing Huang, Xinfang Chen, Zhiya Liu, Xuejuan Pan, Huan Chen, Dandan Zheng, Caicai Ma, Xuemei Hou, Shuya Wang, Chunlei Wang, Weibiao Liao   +12 more
wiley   +1 more source

USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization

Nature Communications, 2018
Histone chaperone ASF1A is often dysregulated in cancers, however the regulation of its abundance is unclear. Here, the authors show that USP52 promotes ASF1A stability through deubiquitination while impairment of this stability reduces breast ...
Shangda Yang, Ling Liu, Cheng Cao, Nan Song, Yuejiao Wang, Shuai Ma, Qi Zhang, Na Yu, Xiang Ding, Fuquan Yang, Shanshan Tian, Kai Zhang, Tao Sun, Jie Yang, Zhi Yao, Shaoyuan Wu, Lei Shi   +16 more
doaj   +1 more source

A stage‐dependent seed defense response to explain efficient seed transmission of Xanthomonas citri pv. fuscans to common bean

Plant, Cell &Environment, EarlyView.
Abstract Although seed represents an important means of plant pathogen dispersion, the seed–pathogen dialogue remains largely unexplored. A multiomic approach was performed at different seed developmental stages of common bean (Phaseolus vulgaris L.) during asymptomatic colonization by Xanthomonas citri pv.
Armelle Darrasse, Łukasz Paweł Tarkowski, Martial Briand, David Lalanne, Nicolas W. G. Chen, Matthieu Barret, Jerome Verdier   +6 more
wiley   +1 more source

Insights Into the Role of Lysine Acetylation of Non‐Histone Proteins in Plant Immunity

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant immunity is regulated by numerous transcriptional and posttranslational mechanisms. Among these, lysine acetylation, which is controlled by lysine acetyltransferases (KATs) and lysine deacetylases (KDACs), has been extensively studied, particularly in the context of epigenetic regulation through histone acetylation.
Jérémy Villette, Chloé Ilbert, Sébastien Aimé, Hoai‐Nam Truong, Marielle Adrian, Stéphane Bourque   +5 more
wiley   +1 more source