Results 151 to 160 of about 237,704 (293)

Cytoskeleton–Membrane Uncoupling in Duchenne Muscular Dystrophy: Implications for Newborn Screening and Early Protection

Cytoskeleton, EarlyView.
ABSTRACT The cytoskeleton of striated muscle integrates force transmission, mechanotransduction, and sarcolemmal stability through coordinated networks of sarcomeres, costameres, and intermediate filaments. Together, these systems establish mechanical continuity between the contractile apparatus, the sarcolemma, and the extracellular matrix.
Houda Cohen, Nora Hosny, Brian R. Thompson, Joseph M. Metzger   +3 more
wiley   +1 more source

Multicomplex Integrative Structural Modeling of a Human Histone Deacetylase Interactome. [PDF]

Mol Cell Proteomics
Nde J, Majila K, Zimmermann RC, Kempf C, Zhang Y, Cesare J, Thornton JL, Workman JL, Florens L, Viswanath S, Washburn MP.   +10 more
europepmc   +1 more source

Histone Deacetylase 7 (HDAC7) Regulates Cell Survival and Amino Acid Metabolism of CD8+ T cells

HISTONE DEACETYLASE 7 (HDAC7) REGULATES CELL SURVIVAL AND AMINO ACID METABOLISM OF CD8+ T CELLS Histone Deacetylase 7 (HDAC7) Regulates Cell Survival and Amino Acid Metabolism of CD8+ T cells / Hsiao, Hsiang-Jung (Rights reserved) (-
Hsiao, Hsiang-Jung
core  

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

Studies on the chromatin-bound histone deacetylase of HeLa cells

, 1983
The reversible acetylation of histones is thought to play a role in chromatin processing, including transcription, replication and repair. Studies on the acetyltransferases, responsible for acetylating the nucleosomal core histones, have resulted in ...
Hay, Colin William
core   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Selective histone deacetylase inhibition as a therapeutically relevant strategy in H3K27M-glioma. [PDF]

Neuro Oncol
Groves A, Kirkland OO, Lo Cascio C, Wang X, Heaslip C, Graca Marques J, Song C, Poetschke R, Wang T, Chin DH, Asante Y, Liu Q, Kim H, Gu S, Trissal M, Labelle J, Veiga Cruzeiro GA, Jones KL, Cameron AB, Clark LM, Leeper B, Nguyen QD, Gryder BE, Filbin MG, Qi J.   +24 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

The histone deacetylase BpHST1 influences branch angle in white birch (Betula platyphylla). [PDF]

Plant J
Hou L, Li B, Liu Y, Zhang Q, Zheng Z.
europepmc   +1 more source

KBG syndrome: A scoping review of electroclinical features of patients with epilepsy

Epileptic Disorders, EarlyView.
Abstract Background and Objectives KBG syndrome is a rare autosomal developmental disorder caused by pathogenic variants of the ANKRD11 gene. This scoping review aimed to explore all current literature data regarding clinical and electroencephalographic features of patients with KBG syndrome and epilepsy. Materials and Methods We conducted a literature
Stefania Kalampokini, Evripidis Pityrigkas, Zoi Kallia, Georgia Pepe, Antonis Frontistis, Dimitrios Profer, Vasilios Kimiskidis   +6 more
wiley   +1 more source