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Assays for Histone Deacetylases
Current Topics in Medicinal Chemistry, 2009Epigenetics is defined as heritable changes in gene expression, i.e. the presentation of a certain phenotype, without alterations to the genetic code. This is a central phenomenon in developmental biology but also for the pathogenesis of a variety of diseases, e.g. for cancer in the case of silencing of tumor suppressor proteins.
Hauser, Alexander-Thomas +2 more
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2008
Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
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Deacetylation of histones is required for gene regulation and cell cycle progression and the mediators, the histone deacetylases, are being vigorously pursued as drug targets for cancer chemotherapy. The deacetylases are also potential drug targets against infectious diseases and genome sequencing revealed proteins of this class in each of three ...
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Histone deacetylases and atherosclerosis
Atherosclerosis, 2015Atherosclerosis is the most common pathological process that leads to cardiovascular diseases, a disease of large- and medium-sized arteries that is characterized by a formation of atherosclerotic plaques consisting of necrotic cores, calcified regions, accumulated modified lipids, smooth muscle cells (SMCs), endothelial cells, leukocytes, and foam ...
Xia-xia, Zheng +4 more
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Histone deacetylase inhibitors
European Journal of Medicinal Chemistry, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
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Histone Deacetylase Inhibitors
2004The base sequence of DNA provides the genetic code for proteins. The regulation of expression or suppression of gene transcription is largely determined by the structure of the chromatin--referred to as epigenetic gene regulation (Agalioti et al., 2002; Jenuwein and Allis, 2001; Richards and Elgin, 2002; Spotswood and Turner, 2002; Zhang and Reinberg ...
Paul A, Marks +3 more
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Carbamazepine is an inhibitor of histone deacetylases
Life Sciences, 2005Carbamazepine (CBZ) is a common antiepileptic drug (AED) that acts through multiple mechanisms including blockade and potentiation of cation channels and modulation of neurotransmitter levels. Whether it affects any component of the gene transcription machinery is unknown.
Andreas S, Beutler +3 more
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Selective Histone Deacetylase Inhibitors
Anti-Cancer Agents in Medicinal Chemistry, 2012Histone deacetylases (HDACs) are a family of conserved metalloproteases which play a key role in the development of cancer. They can be divided into 18 subtypes according to their structural diversity. Histone deacetylase inhibitors are considered as potential anti-cancer agents and a lot of pan-HDAC inhibitors have entered clinical trials.
Huili, Pan, Jiangying, Cao, Wenfang, Xu
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Characterization of pea histone deacetylases
Plant Molecular Biology, 1988The present paper is the first report on histone deacetylases from plants. Three enzyme fractions with histone deacetylase activity (HD0, HD1 and HD2) have been partially purified from pea (Pisum sativum) embryonic axes. They deacetylate biologically acetylated chicken histones and, to a lesser extent, chemically acetylated histones, this being a ...
R, Sendra +3 more
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The Human Histone Deacetylase Family
Experimental Cell Research, 2001Since the identification of the first histone deacetylase (Taunton et al., Science 272, 408-411), several new members have been isolated. They can loosely be separated into entities on the basis of their similarity to various yeast histone deacetylases. The first class is represented by its closeness to the yeast Rpd3-like proteins, and the second most
S G, Gray, T J, Ekström
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Histone Deacetylases, the Erasers of the Code
2016The acetylation of the N-terminal tail domains of core histones provides a rich potential source of epigenetic information. Acetylation involves the addition of an acetyl group to a lysine residue by the action of the histone/lysine acetyltransferase enzymes (HATs/KATs).
Lamberti, María Julia +3 more
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