Results 171 to 180 of about 237,704 (293)

Chronic Prostatitis/Chronic Pelvic Pain Syndrome: Research Progress and Precision Diagnosis‐Therapy Under the Integrated Neuro–Immune–Metabolic–Microbiota Axis Framework

iMetaMed, EarlyView.
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is increasingly recognized as a systemic disorder rather than a purely local prostate disease. The diagram illustrates the transition from the traditional local prostate‐centered model to a multi‐axis systemic framework involving clinical heterogeneity, local prostatic inflammation, systemic ...
Kun Wang, Jinfei Liu, Qiangsheng Wang, Lei Fan, Ziang Li, Xuexin Yu, Yonghao Chen, Xiaofan Lu, Guiyi Liao, Jialin Meng, Yu Guan   +10 more
wiley   +1 more source

Histone deacetylase enzyme activity is not the universal anticancer target of HDAC inhibitors. [PDF]

Signal Transduct Target Ther
Rai C, Ruan H, Li X, Li W, Jeong HH, Song C, Liu P, Chang Y, Fang H, Kumar S U, Sun Y, You MJ, Guan D, Liu Z, Han L, Hou X, Sun Z.   +16 more
europepmc   +1 more source

Organ‐Resolved Host Proteomic and Post‐Translational Modification Landscapes in a Mouse Model of Talaromyces marneffei Infection

iMetaMed, EarlyView.
We presented an organ‐resolved, multiple PTM remodeling atlas of systemic T. marneffei infection, integrating quantitative proteome, phosphoproteome, ubiquitinome, acetylome, and lactylome data across the liver, lung, and spleen. The atlas delineated organ‐specific PTM signatures and a functional convergence of divergent modification types on immune ...
Wudi Wei, Shiyi Lai, Xiaotao He, Xiaoting Wei, Xiaoting Xie, Weihong Huang, Baili Zhan, Meng Zhang, Zongxiang Yuan, Rongfeng Chen, Jingzhen Lai, Yuyuan Huang, Kang Li, Sanqi An, Li Ye, Hao Liang, Junjun Jiang   +16 more
wiley   +1 more source

Design, Synthesis, and Antitumor Activities of Novel Coumarin-Based Histone Deacetylase Inhibitors. [PDF]

Biomolecules
Yan S, Chang J, Lei D, Lv X, Li Y, Zhuo Y, Jin L, Pan L.   +7 more
europepmc   +1 more source

Butyrate ameliorates acute‐on‐chronic liver failure by regulating macrophage polarization

iMetaOmics, EarlyView.
Multi‐omics profiling identifies progressive microbiota‐metabolism‐immunity axis dysfunction in acute‐on‐chronic liver failure (ACLF), characterized by gut dysbiosis, reduced butyrate production, intestinal barrier disruption, microbial translocation, and pro‐inflammatory macrophage polarization, thereby exacerbating hepatic inflammation and fibrosis ...
Jing Xiao, Hang You, Zongyi Liu, Yong Sun, Yu Zhang, Li Wei, Ning Ling, Hong Ren, Shiying Li, Peng Hu, Mingli Peng   +10 more
wiley   +1 more source

Zinc Affinity of Benzamide-Based Histone Deacetylase Inhibitors: A DFT Study. [PDF]

Molecules
Toshev N, Velichkov K, Uzunova Y, Cheshmedzhieva D, Dudev T.   +4 more
europepmc   +1 more source

OXCT1‐driven succinylation of PSMG3 stabilizes the proteasome to facilitate picornavirus replication

iMetaOmics, EarlyView.
Upon entering the pig, foot‐and‐mouth disease virus (FMDV) regulates host glycolysis and the citrate cycle by modulating the expression of metabolic enzymes, resulting in changes in post‐translational modifications (PTMs) including succinylation, lactylation, crotonylation, acetylation, and phosphorylation.
Huisheng Liu, Qiao Xue, Pengfei Liu, Zhihua Dong, Weijun Cao, Fan Yang, Yingming Zhu, Lei Deng, Zixiang Zhu, Haixue Zheng   +9 more
wiley   +1 more source

Histone Deacetylase Meets Protein Degradation: Accelerating Anticancer Drug Discovery. [PDF]

Med Res Rev
Wang JJ, Gao Y, Ji XQ, Yin JY, Zhang MZ, Wang B, Liu HM, Feng S, Wang N, Lu GL, Li Y, Herdewijn P, Zheng YC, Yan P, Dai XJ.   +14 more
europepmc   +1 more source

Epigenetic Regulation in the Pathogenesis of Renal Inflammation: Insights and Therapeutic Potentials

iNew Medicine, EarlyView.
ABSTRACT Renal inflammation is a common pathological process in various kidney diseases, often initiated by factors such as toxins, ischemia, or autoimmune reactions. This inflammatory response can result in structural damage and a rapid decline in renal function.
Yu‐Hang Dong, Xiao‐Yu Shen, Han‐Cheng Jin, Xiang‐Yu Li, Hao He, Xiao‐Ming Meng   +5 more
wiley   +1 more source

Yeast Rpd3L histone deacetylase couples nutrient shifts to genome-wide chromatin reprogramming. [PDF]

Cell Rep
Bhattacharya S, Sutter BM, Tu BP.
europepmc   +1 more source