Histone deacetylase - Open Access .click

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Histone deacetylases (HDAC) are enzymes that regulate biological activity through removal of acetyl groups from histones and non-histone proteins. A few HDAC inhibitors have been approved for use as anti-cancer agents, but their clinical uptake so far has been limited, presumably due to their adverse effect profiles.
Shunsheng Zheng +3 more
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Histone Deacetylase Activity Assay

2009
Histone deacetylases (HDACs) are enzymes that catalyze the removal of acetyl groups from the epsilon-amino groups of conserved lysine residues in the amino terminal tail of histones. In humans, there are 18 potential deacetylase enzymes that are responsible for the removal of acetyl groups and maintenance of the equilibrium of lysine acetylation on ...
Zhigang, Yuan +3 more
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Inhibitors of Histone-deacetylases

Tumori Journal, 2001
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The role of histone deacetylase 4 during chondrocyte hypertrophy and endochondral bone development

Bone and Joint Research, 2020
Xiaochun Wei, Lei Wei
exaly

Histone deacetylase inhibitors: discovery and development as anticancer agents

Expert Opinion on Investigational Drugs, 2005
Paul A Marks, Miloš Dokmanović
exaly

Zinc binding groups for histone deacetylase inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry, 2018
Qixiao Jiang
exaly

Targeting histone deacetylase in cancer therapy

Medicinal Research Reviews, 2006
HSIANG-YÜ Lin, Chang-Shi Chen, Jing-Ru Weng +2 more
exaly

Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC)

Annals of Oncology, 2010
L R Molife, Gerhardt Attard, P C Fong
exaly