Results 191 to 200 of about 105,425 (257)

GV-001, An Oral Available Histone Deacetylase 6 Inhibitor for the Treatment of Autosomal Dominant Polycystic Kidney Disease. [PDF]

J Med Chem
Wu SS, Hung PY, Yeh TY, Lin PJ, Chern JW, Yu CW.   +5 more
europepmc   +1 more source

Molecular and genomic advances in breast cancer: A comprehensive review of predictive and therapeutic innovations

Precision Medical Sciences, EarlyView.
Breast cancer subtypes, estrogen receptor‐positive (ER+), HER2‐enriched, and TNBC, are defined by genomic and epigenetic signatures. Multi‐omics profiling, immunotherapy, liquid biopsy, and AI‐driven radiogenomics enable precision medicine. Tools like Oncotype DX and PAM50 support personalized care.
Samina Malik, Arif Malik, Shahzad Ahmad, Hassan Mohsin, Shazia Iqbal   +4 more
wiley   +1 more source

HISTONE DEACETYLASE-1 is required for epigenome stability in <i>Neurospora crassa</i>. [PDF]

Proc Natl Acad Sci U S A
Ebot-Ojong F, Ferraro AR, Yap RE, Kaddar F, Hull-Crew C, Scadden AW, Deaven AM, Klocko AD, Lewis ZA.   +8 more
europepmc   +1 more source

2‐Amino‐3H‐phenoxazin‐3‐one is a lead inhibitor of Cuscuta campestris early development: structure–activity relationships of o‐aminophenol‐derived allelochemicals

Pest Management Science, EarlyView.
Phenoxazinones caused differential types of phytotoxic effects in C. campestris early development. APO is a coherent lead inhibiting C. campestris germination and early seedling growth. Abstract BACKGROUND 2‐Amino‐3H‐phenoxazin‐3‐one (synonym: questiomycin A; abbreviated as APO or Phx‐3) is a naturally occurring phenoxazinone‐type allelochemical with ...
Cristina Díaz‐Franco, Mónica Fernández‐Aparicio, José MG Molinillo, Rosa M Varela, Francisco A Macías, Jesús G Zorrilla   +5 more
wiley   +1 more source

NF-κB Is a Potential Therapeutic Target for Histone Deacetylase Inhibitor-Resistant Cutaneous T-Cell Lymphoma. [PDF]

Cancer Sci
Takahashi Y, Kitadate A, Iwama S, Kuroki W, Abe K, Yamada M, Ikeda S, Tagawa H, Wakui H, Hikida M, Takahashi N.   +10 more
europepmc   +1 more source

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

Transient histone deacetylase inhibition induces cellular memory of gene expression and 3D genome folding. [PDF]

Nat Genet
Paldi F, Szalay MF, Dufau S, Di Stefano M, Reboul H, Jost D, Bantignies F, Cavalli G.   +7 more
europepmc   +1 more source

Mapping the Radiopharmaceutical Therapy Landscape for Prostate Cancer: Insights Into Global Clinical Trial Trends and Future Directions

Med Research, EarlyView.
Zhiwu Dong, Sixiang Yan, Xiaodong Liu, Peng Gu   +3 more
wiley   +1 more source

Phthalate Metabolite, Mono(2‐Ethyl‐5‐Hydroxyhexyl) Phthalate (MEHHP), Promotes Uterine‐Fibroid–Associated Phenotypes in Myometrial Stem Cell‐Derived 3D Organoids

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates how phthalate exposure contributes to uterine fibroid (UF) development by studying the effects of the Mono‐(2‐ethyl‐5‐hydroxyhexyl) phthalate (MEHHP), a metabolite of Di(2‐ethylhexyl) phthalate, on myometrial stem cells (MMSCs).
Somayeh Vafaei, Mervat M. Omran, Qiwei Yang, Sandra Madueke‐Laveaux, Ami R. Zota, Ayman Al‐Hendy, Mohamed Ali   +6 more
wiley   +1 more source

Design, Synthesis, and Biological Evaluation of Novel Triazine-Based Dual Histone Deacetylase/phosphatidylinositol 3-kinase Inhibitors for Breast Cancer Therapy. [PDF]

ChemMedChem
Luzietti L, Pires GS, Ryan A, Regidor C, Hiller M, Sarti D, Ní Chonghaile T, Pinheiro PSM, Varešlija D, Rodrigues DA.   +9 more
europepmc   +1 more source