Results 191 to 200 of about 237,704 (293)

Correction: Histone deacetylase inhibitors are protective in acute but not in chronic models of ototoxicity. [PDF]

Front Cell Neurosci
Yang CH, Liu Z, Dong D, Schacht J, Arya D, Sha SH.   +5 more
europepmc   +1 more source

Not Just Mycosis Fungoides: A Case Series of Concurrent Fungal Infections in Patients With Cutaneous T‐Cell Lymphoma

JEADV Clinical Practice, EarlyView.
ABSTRACT Mycosis fungoides is a misnomer that means ‘mushroom‐like fungal disease’, but it is, in fact, the most common form of cutaneous T‐cell lymphoma. The diagnosis of mycosis fungoides is often delayed due to non‐specific symptoms and cutaneous signs that mimic other common benign inflammatory dermatoses.
Ji Fung Yong, Orla Smith, Claire Quigley, Stephen Crowther, Shyam B. Verma, Kevin Molloy   +5 more
wiley   +1 more source

Histone deacetylase 3‑mediated histone deacetylation combined with activating transcription factor 3 promotes renal fibrosis by inhibiting Klotho. [PDF]

Mol Med Rep
Yang Z, Wang X, Li W, Chen H, Liu G.
europepmc   +1 more source

Data‐Independent Acquisition Mass Spectrometry in Tumor Classification and Cancer Biomarker Research

Mass Spectrometry Reviews, EarlyView.
Abstract Cancer treatment is far from optimal also because current classification systems do not reflect the complex molecular status of the tumor and its phenotype in sufficient detail. To construct molecular tumor classifiers, omics tools provide complex molecular data reflecting many aspects from genotype to phenotype.
Jan Simonik, Petr Lapcik, Pavla Bouchalova, Pavel Bouchal   +3 more
wiley   +1 more source

Transient histone deacetylase inhibition reveals cell type invariant and specific effects of chromatin decondensation on irradiation response. [PDF]

Front Cell Dev Biol
Li H, Maben C, Young L, Pal D, Davern S, McCord RP.   +5 more
europepmc   +1 more source

Recent Advances in Top‐Down Proteomics for Single‐Cell Research

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley   +1 more source

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Macrocyclic histone deacetylase inhibitor-based near-infrared-responsive ionic nanomedicines for enhanced cancer therapy. [PDF]

Int J Pharm
Oyebade A, Hossain MR, Hasan M, Oluremi A, Rahman MS, Ali N, Griffin RJ, Oyelere AK, Siraj N.   +8 more
europepmc   +1 more source

Proteoforms in Disease: Biomedical Applications of Top‐Down Proteomics

Mass Spectrometry Reviews, EarlyView.
ABSTRACT The proteome is a dynamic landscape of proteoforms arising from genetic mutations, alternative splicing, and post‐translational modifications (PTMs), which collectively drive biological function and disease phenotypes. Mass spectrometry (MS)‐based proteomics has emerged as an essential technique for elucidating this molecular complexity ...
Holden T. Rogers, Zachery R. Gregorich, Megan S. Gant, Zhan Gao, Julia Chamot‐Rooke, Ying Ge   +5 more
wiley   +1 more source

In vitro characterization of the catalytic domain of human histone deacetylase 5. [PDF]

Sci Rep
Mammen C, Hornung FM, Anzenhofer C, Schumacher J, Reiners J, Li J, Mazzone F, Bilsing FL, Kassack MU, Kurz T, Smits SHJ.   +10 more
europepmc   +1 more source