Results 231 to 240 of about 167,650 (273)

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source

Multiscale Effects of Environmentally Relevant Mixtures Containing Two Estrogenic Endocrine Disruptors, Chlordecone and Propylparaben, in Hydra vulgaris Pallas, 1766

Environmental Toxicology, EarlyView.
ABSTRACT This study investigates the chronic effects of chlordecone (CLD) and propylparaben (PP), two pro‐estrogenic endocrine disruptors, on Hydra vulgaris Pallas, 1766 using a multiscale approach over a 14‐day exposure period. Environmentally relevant concentrations of CLD (0.5, 5, 20 μg L−1) and PP (0.01, 0.05, 0.40 μg L−1) were tested individually ...
Magali Domallain, Romain Colpaert, Xavier Moreau, Laetitia De Jong, Karim Benbrahim, Raphael Coatmeur, Valérie Pique, Maxime Robin, Pierre‐Henri Villard   +8 more
wiley   +1 more source

Epigenetic Control of Stress-Induced Depression: Emerging Roles of HDAC3 and HDAC6. [PDF]

Int J Mol Sci
Mohan AS, Jayasankar N, Kashid VA, Patel RJ, Prajapati B.   +4 more
europepmc   +1 more source

immunoHuMiX: A personalizable gut‐on‐chip model for unraveling human microbiome–immune interactions

VIEW, EarlyView.
The study introduces a personalized gut model that brings together human immune cells and intestinal cells to better mimic how the body interacts with microbes. This system successfully maintained both human cells and a 17‐strain probiotic community, showing consistent immune responses across different donors.
Charlotte De Rudder, Kacy Greenhalgh, Joanna Baginska, Camille Martin‐Gallausiaux, Léa Grandmougin, Rémy Villette, Mara Lucchetti, Bérénice Hansen, Marek Ostaszewski, Viacheslav A. Petrov, Koji Atarashi, Lena Weidert, Audrey Frachet Bour, Dominik Ternes, Javier Ramiro‐Garcia, Antoine Malabirade, Takeshi Tanoue, Marc Mac Giolla Eain, Elisabeth Letellier, Matthew Barrett, Jérôme Lacombe, Frederic Zenhausern, Coralie Guérin, Markus Ollert, Carole Seguin‐Devaux, Kenya Honda, Paul Wilmes   +26 more
wiley   +1 more source

Selective histone deacetylase inhibition as a therapeutically relevant strategy in H3K27M-glioma. [PDF]

Neuro Oncol
Groves A, Kirkland OO, Lo Cascio C, Wang X, Heaslip C, Graca Marques J, Song C, Poetschke R, Wang T, Chin DH, Asante Y, Liu Q, Kim H, Gu S, Trissal M, Labelle J, Veiga Cruzeiro GA, Jones KL, Cameron AB, Clark LM, Leeper B, Nguyen QD, Gryder BE, Filbin MG, Qi J.   +24 more
europepmc   +1 more source

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Molecular and Functional Characterization of Histone Deacetylase 4 (HDAC4).

Methods in molecular biology, 2016
Histone deacetylases (HDACs) regulate various nuclear and cytoplasmic processes. In mammals, these enzymes are divided into four classes, with class II further divided into two subclasses: IIa (HDAC4, HDAC5, HDAC7, HDAC9) and IIb (HDAC6 and HDAC10). While HDAC6 is mainly cytoplasmic and HDAC10 is pancellular, class IIa HDACs are dynamically shuttled ...
Lin Li, Xiang-Jiao Yang
semanticscholar   +3 more sources

Histone deacetylase 4 mediates high glucose-induced podocyte apoptosis via upregulation of calcineurin.

Biochemical and Biophysical Research Communications - BBRC, 2020
Hyperglycemia promotes podocyte apoptosis and plays an important role in the pathogenesis of diabetic nephropathy (DN). Calcium/calcineurin (CaN) signaling is critical for podocyte apoptosis.
Wanxin Shi, Ying Huang, Xing-Chen Zhao, Zhi-Yong Xie, W. Dong, Rui-Zhao Li, Yuan-Han Chen, Zhuo Li, Wen-Jian Wang, Zhi-Ming Ye, Shuang-Xin Liu, Li Zhang, Xin-Ling Liang   +12 more
semanticscholar   +1 more source

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart from Failure.

Circulation, 2019
BACKGROUND World-wide, diabetes and heart failure represent frequent comorbidities with high socioeconomic impact and steadily growing incidence, calling for a better understanding of how diabetic metabolism promotes cardiac dysfunction.
Mariya Kronlage, M. Dewenter, Johannes Grosso, T. Fleming, Ulrike Oehl, L. Lehmann, I. Falcão-Pires, A. Leite-Moreira, Nadine Volk, H. Grone, O. Müller, A. Sickmann, H. Katus, J. Backs   +13 more
semanticscholar   +1 more source