Results 241 to 250 of about 167,650 (273)

Histone deacetylase 4 (HDAC4): a new player in anorexia nervosa?

Molecular Psychiatry, 2019
Anorexia nervosa (AN) and other eating disorders continue to constitute significant challenges for individual and public health. AN is thought to develop as a result of complex interactions between environmental triggers, psychological risk factors, sociocultural influences, and genetic vulnerability.
M. Sild, L. Booij
semanticscholar   +3 more sources

Adenovirus-mediated transduction with Histone Deacetylase 4 ameliorates disease progression in an osteoarthritis rat model.

International Immunopharmacology, 2019
BACKGROUND Downregulation of histone deacetylase-4 (HDAC4) contributes to cartilage degeneration in osteoarthritis (OA) because it promotes upregulation of runt-related transcription factor-2 (Runx-2) and osteoarthritis-related genes. The effect of HDAC4
X. Gu, Lei Wei, Peng-cui Li, X. Che, Rui-Peng Zhao, Peng-Fei Han, Jian-gong Lu, Xiao-Chun Wei   +7 more
semanticscholar   +1 more source

Function and regulation of histone deacetylase 4

2006
Histone acetyltransferases and histone deacetylases (HDACs) maintain dynamic acetylation and deacetylation of histories and other proteins in vivo, and are actively involved in the control of gene transcription and other nuclear processes. One mechanism by which functions of these enzymes are regulated operates through differential intracellular ...
openaire   +1 more source

Histone deacetylase inhibitor, apicidin, inhibits human ovarian cancer cell migration via class II histone deacetylase 4 silencing

Cancer Letters, 2012
This study examined the molecular mechanisms of apicidin in the modulation of human ovarian cancer SKOV-3 cells invasion and migration. Apicidin markedly decreased histone deacetylase 4 (HDAC4) expression and blocked cell migration and invasion. Cell migration was inhibited via down-regulation of matrix metalloproteinase-2 (MMP-2) and up-regulation of ...
Mee Young, Ahn, Dong O, Kang, Yong Jin, Na, Sungpil, Yoon, Whan Soo, Choi, Keun Wook, Kang, Hae Young, Chung, Jee H, Jung, Do Sik, Min, Hyung Sik, Kim   +9 more
openaire   +2 more sources

Histone Deacetylase 4: The Epigenetic Hub in Degenerative Musculoskeletal Diseases

Endocrine, Metabolic & Immune Disorders - Drug Targets
Abstract: Aging has rendered Degenerative Musculoskeletal Diseases (DMDs) an increasingly significant public health burden. Growing evidence suggests that epigenetic dysregulation plays a crucial mechanistic role in the pathogenesis of DMDs.
Junyan Huang, Zhengming Wang, Guoqing Du, Zhaozhou Zhang, Mingcai Zhang, Yuanyuan Feng, Yayi Tan, Hong Zhao, Shanshan Zhang, Yizhe Xiong, Xiang Wang, Jun Shen, Hongsheng Zhan   +12 more
openaire   +1 more source

A proteolytic fragment of histone deacetylase 4 protects the heart from failure by regulating the hexosamine biosynthetic pathway

Nature Medicine, 2017
L. Lehmann, Z. H. Jebessa, M. Kreusser, A. Horsch, T. He, Mariya Kronlage, M. Dewenter, Viviana Sramek, Ulrike Oehl, Jutta Krebs-Haupenthal, A. von der Lieth, Andrea Schmidt, Qiang Sun, J. Ritterhoff, D. Finke, M. Völkers, A. Jungmann, S. Sauer, C. Thiel, A. Nickel, M. Kohlhaas, Michael Schäfer, C. Sticht, C. Maack, N. Gretz, M. Wagner, A. El-Armouche, L. Maier, J. C. Camacho Londoño, B. Meder, M. Freichel, H. Grone, P. Most, O. Müller, S. Herzig, E. Furlong, H. Katus, J. Backs   +37 more
semanticscholar   +1 more source

Histone deacetylase 4 is a transcriptional corepressor regulated by nucleocytoplasmic shuttling

2003
This item was digitized as part of a project to share McGill's intellectual legacy with the public. If you are the copyright holder or a relative of the copyright holder who is deceased, you may request withdrawal by emailing escholarship.library@mcgill.ca.
openaire   +1 more source

Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson’s Disease

Molecular Neurobiology, 2017
Qimei Wu, Xiaoyu Yang, Lei Zhang, Yu Zhang, Lin-Yin Feng   +4 more
semanticscholar   +1 more source

Histone deacetylase inhibitors: discovery and development as anticancer agents

Expert Opinion on Investigational Drugs, 2005
Milos Dokmanovic, Paul Marks
exaly  

Phase II, two-stage, single-arm trial of the histone deacetylase inhibitor (HDACi) romidepsin in metastatic castration-resistant prostate cancer (CRPC)

Annals of Oncology, 2010
Gerhardt Attard, L R Molife, P C Fong
exaly