Results 1 to 10 of about 14,188 (207)

Increased Abundance of Nuclear HDAC4 Impairs Neuronal Development and Long-Term Memory

Frontiers in Molecular Neuroscience, 2021
Dysregulation of the histone deacetylase HDAC4 is associated with both neurodevelopmental and neurodegenerative disorders, and a feature common to many of these disorders is impaired cognitive function. HDAC4 shuttles between the nucleus and cytoplasm in
Helen Fitzsimons, Patrick Main
exaly   +4 more sources

Targeting CKIP-1 for Disease Therapy: Cellular Functions, Molecular Networks, and Clinical Potential. [PDF]

Cell Prolif
CKIP‐1, as a scaffold protein with special structural domains, treats related diseases through multiple emerging targeted technologies.
Huang X, Lv S, Li L, Xie J, Cao Z.
europepmc   +2 more sources

Multi-omics identifies promoter methylation and gene expression changes associated with human skeletal muscle atrophy. [PDF]

Exp Physiol
Abstract Skeletal muscle atrophy is a secondary complication in the aetiology of injury and chronic disease. Identifying mechanisms that control muscle mass is necessary to characterise atrophy and develop prevention strategies. We aimed to integrate transcriptomic and epigenomic data to identify key regulatory pathways controlled by promoter DNA ...
Thompson JM, Doering TM, Budiono BP, Mackenzie-Shalders KL, Ashton KJ, Dunn PJ, Coffey VG.   +6 more
europepmc   +2 more sources

ZER1 Restrains Pressure Overload-Induced Cardiac Remodeling by Targeting DVL2 for Gly/N-Degron-Dependent Degradation. [PDF]

Adv Sci (Weinh)
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Jiang M, Lin Z, Chen L, Ni Y, Zhou J, Zhang W, Wang H, Ying P, Lu X, Wang K, Kong Q, Xu N, Zhao D, Li J, Zhong G, Meng X, Hamad S, Zheng J, Fu Y, Qin R, Chu X, Li S, Li Y, Wu Y, Wang Y, Song W, Li Y, Ling S.   +27 more
europepmc   +2 more sources

HDAC4 Regulates the Proliferation, Differentiation and Apoptosis of Chicken Skeletal Muscle Satellite Cells

Animals, 2020
The development of skeletal muscle satellite cells (SMSCs) is a complex process that could be regulated by many genes. Previous studies have shown that Histone Deacetylase 4 (HDAC4) plays a critical role in cell proliferation, differentiation, and ...
Huadong Yin, Haorong He, Shunshun Han
exaly   +3 more sources

N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in Drosophila [PDF]

Open Biology
Histone deacetylase four (HDAC4) undergoes dynamic nucleocytoplasmic shuttling, a process critical for regulating its activity. However, aberrant nuclear accumulation of HDAC4 is associated with both neurodevelopmental and neurodegenerative disease, and ...
Hannah R. Hawley, Andrew J. Sutherland-Smith, Matthew S. Savoian, Helen L. Fitzsimons   +3 more
doaj   +2 more sources

HDAC4 Controls Muscle Homeostasis through Deacetylation of Myosin Heavy Chain, PGC-1α, and Hsc70

Cell Reports, 2019
Summary: HDAC4, a class IIa histone deacetylase, is upregulated in skeletal muscle in response to denervation-induced atrophy. When HDAC4 is deleted postnatally, mice are partially protected from denervation. Despite the name “histone” deacetylase, HDAC4
Leo Widler, Serge Summermatter
exaly   +3 more sources

Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions have never been ...
Dario Coletti, Antonello Mai, Sergio Adamo   +2 more
exaly   +2 more sources

An HDAC4-specific PROTAC degrader achieves radiation sensitization by enhancing ferroptosis in lung cancer [PDF]

Nature Communications
Post-translational modifications (PTMs) play a critical role in cancer radioresistance, yet how they regulate ferroptosis to influence radiotherapy response remains poorly understood.
Chun Cheng, Longhua Sun, Jiaxue Yang, Zhiliang Liu, Fan Zhang, Lingyan Qiu, Meng Yu, Ting Wang, Jianxin Huang, Li Wang, Wei-Ping Min, Tingxiu Xiang, Kaishun Hu, Yi Sang   +13 more
doaj   +2 more sources

HDAC4 mutant represses chondrocyte hypertrophy by locating in the nucleus and attenuates disease progression of posttraumatic osteoarthritis

BMC Musculoskeletal Disorders, 2022
Background The aim of this study was to evaluate whether histone deacetylase 4 S246/467/632A mutant (m-HDAC4) has enhanced function at histone deacetylase 4 (HDAC4) to attenuate cartilage degeneration in a rat model of osteoarthritis (OA).
Xiaodong Gu, Fei Li, Yangyang Gao, Xianda Che, Pengcui Li   +4 more
doaj   +1 more source