Results 21 to 30 of about 14,188 (207)

The Chicken HDAC4 Promoter and Its Regulation by MYC and HIF1A

Genes
Background: Histone deacetylase 4 (HDAC4) is a member of the class II histone deacetylase family, whose members play a crucial role in various biological processes. An in-depth investigation of the transcriptional characteristics of chicken HDAC4 can provide fundamental insights into its function.
Yingjie Wang, Ruihong Kong, Ke Xie, Xu Wang, Han Wu, Yani Zhang   +5 more
openaire   +3 more sources

Effects of HDAC4 on IL-1β-induced matrix metalloproteinase expression regulated partially through the WNT3A/β-catenin pathway

Chinese Medical Journal, 2021
. Background:. Histone deacetylase 4 (HDAC4) regulates chondrocyte hypertrophy and bone formation. The aim of the present study was to explore the effects of HDAC4 on Interleukin 1 beta (IL-1β)-induced chondrocyte extracellular matrix degradation and ...
Qi Ning, Ye-Hua Gan, Rui-Rui Shi, Juan-Hong Meng, Xiu-Yuan Hao   +4 more
doaj   +1 more source

Upregulated ribosome pathway plays a key role in HDAC4, improving the survival rate and biofunction of chondrocytes

Bone & Joint Research, 2023
Aims: To explore the novel molecular mechanisms of histone deacetylase 4 (HDAC4) in chondrocytes via RNA sequencing (RNA-seq) analysis. Methods: Empty adenovirus (EP) and a HDAC4 overexpression adenovirus were transfected into cultured human chondrocytes.
Li Guo, Hua Guo, Yuanyu Zhang, Zhi Chen, Jian Sun, Gaige Wu, Yunfei Wang, Yang Zhang, Xiaochun Wei, Pengcui Li   +9 more
doaj   +1 more source

PP2A Regulates HDAC4 Nuclear Import [PDF]

Molecular Biology of the Cell, 2008
Different signal-regulated serine/threonine kinases phosphorylate class II histone deacetylases (HDACs) to promote nuclear export, cytosolic accumulation, and activation of gene transcription. However, little is known about mechanisms operating in the opposite direction, which, possibly through phosphatases, should promote class II HDACs nuclear entry ...
BRANCOLINI, Claudio, CERNOTTA, Nadia, DELLO RUSSO C., FOTI, Carmela, GALLINARI P, ORSATTI L., PALLAORO M., PARONI, Gabriela, STEINKUHLER C, TALAMO F.   +9 more
openaire   +3 more sources

HDAC4 [PDF]

Cell, 2004
RUNX2 is a transcription factor with a well-characterized role in bone development. In this issue of Cell, Vega and colleagues (Vega et al., 2004) show that HDAC4 interacts with RUNX2 and impacts upon chondrocyte hypertrophy and bone formation.
openaire   +3 more sources

Pharmacological and Genetic Inhibition of HDAC4 Alleviates Renal Injury and Fibrosis in Mice

Frontiers in Pharmacology, 2022
Histone deacetylase 4 (HDAC4) has been shown to be involved in cell proliferation, differentiation, and migration and is associated with a variety of cancers. However, the role of HDAC4 in renal fibrogenesis and its mechanisms are unclear.
Fengchen Shen, Xiying Hou, Tingting Li, Jianjun Yu, Huizhen Chen, Na Liu, Andong Qiu, Shougang Zhuang, Shougang Zhuang   +8 more
doaj   +1 more source

Dephosphorylation of HDAC4 by PP2A-Bδ unravels a new role for the HDAC4/MEF2 axis in myoblast fusion [PDF]

Cell Death & Disease, 2019
AbstractMuscle formation is controlled by a number of key myogenic transcriptional regulators that govern stage-specific gene expression programs and act as terminal effectors of intracellular signaling pathways. To date, the role of phosphatases in the signaling cascades instructing muscle development remains poorly understood.
Veloso, Alexandra, Martin, Maud, Bruyr, Jonathan, O'Grady, Tina, Deroanne, Christophe, Mottet, Denis, Twizere, Jean-Claude, Cherrier, Thomas, Dequiedt, Franck   +8 more
openaire   +3 more sources

RETRACTED: HDAC4 depletion ameliorates IL‐13‐triggered inflammatory response and mucus production in nasal epithelial cells via activation of SIRT1/NF‐κB signaling

Immunity, Inflammation and Disease, 2022
Introduction Allergic rhinitis (AR) is frequently known as a chronic respiratory disease with a global high prevalence. The pivotal roles of histone deacetylase 4 (HDAC4) in multiple human diseases have been underlined by numerous studies.
Hangyu Xu, Lingjun Wang, Huaqun Chen, Hefei Cai   +3 more
doaj   +1 more source

Histone Deacetylase 4 Promotes Osteosarcoma Cell Proliferation and Invasion by Regulating Expression of Proliferating Cell Nuclear Antigen

Frontiers in Oncology, 2019
Background/Aims: Osteosarcoma (OS) is commonly characterized by lower survival rates and high incidences of local recurrence due to its highly aggressive nature and metastatic tendencies.
Kun Cao, Hao Wang, Yueyang Fang, Yuan Wang, Lei Wei, Xi Chen, Zheng Jiang, Xiaochun Wei, Yong Hu   +8 more
doaj   +1 more source

Differential localization of HDAC4 orchestrates muscle differentiation [PDF]

Nucleic Acids Research, 2001
The class II histone deacetylases HDAC4 and HDAC5 interact specifically with the myogenic MEF2 transcription factor and repress its activity. Here we show that HDAC4 is cytoplasmic during myoblast differentiation, but relocates to the nucleus once fusion has occurred. Inappropriate nuclear entry of HDAC4 following overexpression suppresses the myogenic
E A, Miska, E, Langley, D, Wolf, C, Karlsson, J, Pines, T, Kouzarides   +5 more
openaire   +2 more sources