Results 11 to 20 of about 14,188 (207)

Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology

Journal of Medicinal Chemistry, 2022
Huntington's disease (HD) is a lethal autosomal dominant neurodegenerative disorder resulting from a CAG repeat expansion in the huntingtin (HTT) gene. The product of translation of this gene is a highly aggregation-prone protein containing a polyglutamine tract >35 repeats (mHTT) that has been shown to colocalize with histone deacetylase 4 (HDAC4) in ...
Natsuko Macabuag, William Esmieu, Perla Breccia, Rebecca Jarvis, Wesley Blackaby, Ovadia Lazari, Liudvikas Urbonas, Maria Eznarriaga, Rachel Williams, Annelieke Strijbosch, Rhea Van de Bospoort, Kim Matthews, Cole Clissold, Tammy Ladduwahetty, Huw Vater, Patrick Heaphy, Douglas G. Stafford, Hong-Jun Wang, John E. Mangette, George McAllister, Vahri Beaumont, Thomas F. Vogt, Hilary A. Wilkinson, Elizabeth M. Doherty, Celia Dominguez   +24 more
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HDAC4 Inhibitors as Antivascular Senescence Therapeutics [PDF]

Oxidative Medicine and Cellular Longevity, 2022
Aging is an inevitable consequence of life, and during this process, the epigenetic landscape changes and reactive oxygen species (ROS) accumulation increases. Inevitably, these changes are common in many age‐related diseases, including neurodegeneration, hypertension, and cardiovascular diseases. In the current research, histone deacetylation 4 (HDAC4)
Chuoji Huang, Zhongxiao Lin, Xiaoyan Liu, Qian Ding, Jianghong Cai, Zhongyi Zhang, Peter Rose, Yi Zhun Zhu   +7 more
core   +4 more sources

HDAC4 integrates PTH and sympathetic signaling in osteoblasts [PDF]

Journal of Cell Biology, 2014
Parathyroid hormone (PTH) and the sympathetic tone promote Rankl expression in osteoblasts and osteoclast differentiation by enhancing cyclic adenosine monophosphate production through an unidentified transcription factor for PTH and through ATF4 for the sympathetic tone.
Obri, Arnaud, Makinistoglu, Munevver Parla., Zhang, Hong, Karsenty, Gerard   +3 more
openaire   +5 more sources

HDAC4 in ischemic stroke: mechanisms and therapeutic potential [PDF]

Clinical Epigenetics, 2018
Stroke is one of the leading causes of death and disability worldwide, and the majority of the cases are ischemic stroke. However, it still lacks effective treatment except for thrombolytic therapy in an extremely narrow time window. Increased evidence suggests that histone deacetylase 4 (HDAC4) was dysregulated in ischemic stroke, which plays a key ...
Qingsheng Kong, Yongnan Hao, Xin Li, Xin Wang, Bingyuan Ji, Yili Wu   +5 more
openaire   +4 more sources

The histone deacetylase HDAC4 regulates long-term memory in Drosophila. [PDF]

PLoS ONE, 2013
A growing body of research indicates that pharmacological inhibition of histone deacetylases (HDACs) correlates with enhancement of long-term memory and current research is concentrated on determining the roles that individual HDACs play in cognitive ...
Helen L Fitzsimons, Silvia Schwartz, Fiona M Given, Maxwell J Scott   +3 more
doaj   +2 more sources

Histone deacetylase HDAC4 promotes gastric cancer SGC-7901 cells progression via p21 repression. [PDF]

PLoS ONE, 2014
Gastric cancer (GC) is one of the leading causes of cancer death in the world. The role of histone deacetylase 4 (HDAC4) in specific cell and tissue types has been identified.
Zhen-Hua Kang, Chun-Yan Wang, Wen-Liang Zhang, Jian-Tao Zhang, Chun-Hua Yuan, Ping-Wei Zhao, Yu-Yang Lin, Sen Hong, Chen-Yao Li, Lei Wang   +9 more
doaj   +2 more sources

Beside the MEF2 axis: Unconventional functions of HDAC4

Cellular Signalling, 2013
The class IIa deacetylase HDAC4 is unequivocally known as a negative regulator of MEF2-dependent transcription. In the past years several works have allowed us to understand how different signals, mirroring specific environmental circumstances keep in check the repressive action of HDAC4 against MEF2s.
Clocchiatti A, DI Giorgio E, Demarchi F, BRANCOLINI, Claudio   +3 more
openaire   +3 more sources

HDAC4 is required for inflammation-associated thermal hypersensitivity [PDF]

The FASEB Journal, 2015
Transcriptional alterations are characteristic of persistent pain states, but the key regulators remain elusive. HDAC4 is a transcriptional corepressor that has been linked to synaptic plasticity and neuronal excitability, mechanisms that may be involved in peripheral and central sensitization.
Crow, Megan, Khovanov, Nikita, Kelleher, Jayne H, Sharma, Simone, Grant, Andrew D, Bogdanov, Yury, Wood, John N, McMahon, Stephen B, Denk, Franziska   +8 more
openaire   +5 more sources

HDAC4: an emerging target in diabetes mellitus and diabetic complications

European Journal of Medical Research
Diabetes mellitus (DM) is a metabolic disease with complex pathogenic mechanisms. Histone deacetylase 4 (HDAC4) is a member of an important family of epigenetic modifications.
Yiqi Lin, Yuetong Li, Caiying Ke, Ying Jin, Wanwen Lao, Yiling Wu, Yang Liu, Xinyi Kong, Jie Qiao, Aixia Zhai, Changlong Bi   +10 more
doaj   +3 more sources

Somatic Hdac4-902fs mutations lead to loss of HDAC4 function through nonsense-mediated mRNA degradation

Abstract Histone deacetylases (HDACs) are essential chromatin regulators and are involved in the regulation of gene expression by removing acetyl groups from histone and non-histone proteins. Histone deacetylase 4 (HDAC4) is known to regulate the process of endochondral ossification in mice by non-enzymatic repression of the activity of
Harikrishnareddy Paluvai, Mark E. Pepin, Friederike Schreiter, Alireza Saadatmand, Marco Hagenmueller, Johannes Backs   +5 more
openaire   +2 more sources