Results 31 to 40 of about 14,188 (207)
Role of Glucocorticoid Signaling and HDAC4 Activation in Diaphragm and Gastrocnemius Proteolytic Activity in Septic Rats [PDF]
, 2022 Sepsis increases glucocorticoid and decreases IGF-1, leading to skeletal muscle wasting and cachexia. Muscle atrophy mainly takes place in locomotor muscles rather than in respiratory ones.
Priego, Teresa +17 more
core +1 more source
Irisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4. [PDF]
PLoS ONE, 2016 Irisin is a recently identified myokine which brings increases in energy expenditure and contributes to the beneficial effects of exercise through the browning of white adipose tissues. However, its effects in the heart remains unknown. This study sought
Yu Tina Zhao +5 more
doaj +1 more source
Frontiers in Cellular Neuroscience, 2021 Denervation can activate the catabolic pathway in skeletal muscle and lead to progressive skeletal muscle atrophy. At present, there is no effective treatment for muscle atrophy. Histone deacetylase 4 (HDAC4) has recently been found to be closely related
Wenjing Ma +9 more
doaj +1 more source
HDAC4 regulates satellite cell proliferation and differentiation by targeting P21 and Sharp1 genes
Scientific Reports, 2018 Skeletal muscle exhibits a high regenerative capacity, mainly due to the ability of satellite cells to replicate and differentiate in response to appropriate stimuli. Epigenetic control is effective at different stages of this process.
Nicoletta Marroncelli +9 more
doaj +1 more source
HDAC4 promotes nasopharyngeal carcinoma progression and serves as a therapeutic target
Cell Death and Disease, 2021 Histone deacetylases (HDACs) are involved in tumor progression, and some have been successfully targeted for cancer therapy. The expression of histone deacetylase 4 (HDAC4), a class IIa HDAC, was upregulated in our previous microarray screen.
Chun Cheng +6 more
doaj +1 more source
Frontiers in Medicine, 2022 PurposeHistone deacetylase 4 (HDAC4) regulates the progression of autoimmune diseases. This study aimed to further investigate the correlation between HDAC4 and Th cells, inflammation, disease activity, and treatment response in patients with ankylosing ...
Bin Dou +3 more
doaj +1 more source
Role of Phosphorylated HDAC4 in Stroke-Induced Angiogenesis [PDF]
BioMed Research International, 2017 Acetylation or deacetylation of chromatin proteins and transcription factors is part of a complex signaling system that is involved in the control of neurological disorders. Recent studies have demonstrated that histone deacetylases (HDACs) exert protective effects in attenuating neuronal injury after ischemic insults.
Juan Liu +9 more
openaire +2 more sources
Overexpression of histone deacetylase 4 inhibits proliferation and invasion of colorectal cancer cells [PDF]
Jichu yixue yu linchuangObjective To investigate the regulatory role of histone deacetylase 4(HDAC4) overexpression in the proliferation and invasion of human colorectal cancer (CRC) cells.
LIU Huoxi, HUANG Botian, ZHAO Yuntao, ZHANG Jiayang, WU Wenmei
doaj +1 more source
Frontiers in Physiology, 2022 Craniofacial development involves the regulation of a compendium of transcription factors, signaling molecules, and epigenetic regulators. Histone deacetylases (HDACs) are involved in the regulation of cell proliferation, differentiation, and homeostasis
Nayoung Ha +9 more
doaj +1 more source
Nuclear translocation of histone deacetylase 4 induces neuronal death in stroke
Neurobiology of Disease, 2016 Mounting evidence suggests that epigenetic modifications play critical roles in the survival/death of stressed neurons. Chief among these modifications is the deacetylation of histones within the chromatin by histone deacetylases (HDACs). HDAC4 is highly
Hui Yuan +6 more
doaj +1 more source