Results 51 to 60 of about 14,188 (207)

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas [PDF]

Science, 2009
Histone deacetylase 4 (HDAC4) shuttles between the nucleus and cytoplasm and serves as a nuclear co-repressor that regulates bone and muscle development. We report that HDAC4 regulates the survival of retinal neurons in the mouse in normal and pathological conditions.
Bo, Chen, Constance L, Cepko
openaire   +2 more sources

Protein kinase A mediates novel serine-584 phosphorylation of HDAC4 [PDF]

, 2019
Given the well-established diversified signaling pathways for histone deacetylase 4 (HDAC4) and the regulation of HDAC4 by several post-translational modifications (PTMs), including phosphorylation, sumoylation, and ubiquitination, an unbiased and ...
Doddi, Shanmukha K., M.V., Jagannadam, Kummari, Githavani, Kalle, Arunasree M   +3 more
core   +1 more source

hdac4 mediates perichondral ossification and pharyngeal skeleton development in the zebrafish [PDF]

PeerJ, 2019
Background Histone deacetylases (HDACs) are epigenetic factors that function to repress gene transcription by removing acetyl groups from the N-terminal of histone lysines.
April DeLaurier, Cynthia Lizzet Alvarez, Kali J Wiggins   +2 more
doaj   +2 more sources

Seneca Valley virus 3C protease cleaves HDAC4 to antagonize type I interferon signaling

Journal of Virology
Seneca Valley virus (SVV) is a newly identified pathogen that poses a notable threat to the global pig industry. SVV has evolved multiple strategies to evade host antiviral innate immune responses.
Zijian Li, Jingjing Yang, Ruiyi Ma, Shijie Xie, Dan Wang, Rong Quan, Xuexia Wen, Jue Liu, Jiangwei Song   +8 more
doaj   +1 more source

The epigenetic landscape of skeletal muscle in response to exercise and aging

The FEBS Journal, EarlyView.
Epigenetic mechanisms regulate gene expression in response to exercise and aging, thereby supporting skeletal muscle plasticity. Acute exercise induces chromatin remodeling through histone modifications and DNA methylation, promoting the expression of exercise‐responsive genes.
Sabrina Champsi, David A. Hood
wiley   +1 more source

HDAC4 induces relocation of MEF2 in nuclei.

, 2013
A. Confocal projection through the posterior brain showing expression of MEF2 (green) and HDAC4 (red) in Kenyon cells. Scale bar = 50 μm. B. A single confocal plane (1 μm) through the Kenyon cells at the level of the calyx (asterisk) shows MEF2 is ...
Silvia Schwartz (162929), Maxwell J. Scott (192572), Fiona M. Given (494601), Helen L. Fitzsimons (192571)   +3 more
core   +1 more source

Epigenomic Cascades Across Organs in Metabolic Dysfunction–Associated Steatotic Liver Disease: New Therapeutic Horizons

Obesity Reviews, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is the most common chronic liver disorder worldwide, affecting approximately one‐third of the population and increasing the risk of severe hepatic and cardiovascular complications.
Shurui Yang, Zhongyu Huang, Sanchun Tan, Fengxia Liang, Li Chen   +4 more
wiley   +1 more source

Epigenetic influence of KAT6B and HDAC4 in the development of skeletal malocclusion [PDF]

American Journal of Orthodontics and Dentofacial Orthopedics, 2013
Genetic influences on the development of malocclusion include heritable effects on both masticatory muscles and jaw skeletal morphology. Beyond genetic variations, however, the characteristics of muscle and bone are also influenced by epigenetic mechanisms that produce differences in gene expression.
Huh, Ahrin, Horton, Michael J, Cuenco, Karen T, Raoul, Gwenael, Rowlerson, Anthea M, Ferri, Joel, Sciote, James J   +6 more
openaire   +3 more sources

HDAC4 preserves skeletal muscle structure following long-term denervation by mediating distinct cellular responses

Skeletal Muscle, 2018
Background Denervation triggers numerous molecular responses in skeletal muscle, including the activation of catabolic pathways and oxidative stress, leading to progressive muscle atrophy.
Eva Pigna, Alessandra Renzini, Emanuela Greco, Elena Simonazzi, Stefania Fulle, Rosa Mancinelli, Viviana Moresi, Sergio Adamo   +7 more
doaj   +1 more source

Toward “Obesityomics”: Domain‐Specific Omics in Precision Obesity Medicine with a Brief AI Perspective

Obesity Reviews, EarlyView.
ABSTRACT Background Obesity's global rise has outpaced the effectiveness of “one‐size‐fits‐all” prevention and treatment strategies. The promise of precision medicine lies in addressing the etiological and biological diversity of obesity and transforming it into actionable endotypes.
Nadia Abu Samra, Sara G. I. Suliman, Mohammed Al‐Hadad, Dorret I. Boomsma, Fadwa Alhantoobi, Maithah Alsamahi, Haneen Abufarajallah, Alia Al Tikriti, Zeyar Aung, Selena Richards, Abdulrahim Sajini, Mira Mousa, Fatima Sulaiman, Wael Osman   +13 more
wiley   +1 more source