Results 61 to 70 of about 14,188 (207)

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations [PDF]

Journal of Clinical Investigation, 2013
Anorexia nervosa and bulimia nervosa are common and severe eating disorders (EDs) of unknown etiology. Although genetic factors have been implicated in the psychopathology of EDs, a clear biological pathway has not been delineated. DNA from two large families affected by EDs was collected, and mutations segregating with illness were identified by whole-
Huxing, Cui, Jarrette, Moore, Sunbola S, Ashimi, Brittany L, Mason, Jordan N, Drawbridge, Shizhong, Han, Benjamin, Hing, Abigail, Matthews, Carrie J, McAdams, Benjamin W, Darbro, Andrew A, Pieper, David A, Waller, Chao, Xing, Michael, Lutter   +13 more
openaire   +2 more sources

A Direct HDAC4-MAP Kinase Crosstalk Activates Muscle Atrophy Program.

, 2012
Prolonged deficits in neural input activate pathological muscle remodeling, leading to atrophy. In denervated muscle, activation of the atrophy program requires HDAC4, a potent repressor of the master muscle transcription factor MEF2.
Simmons, Bryan J, Li, Ming, Cox, Gregory A, Cohen, Todd J, Choi, Moon-Chang, Zhao, Yingming, Barrientos, Tomasa, Yang, Jeong Soo, Yao, Tso-Pang, Wang, Bin   +9 more
core   +1 more source

Interfering histone deacetylase 4 inhibits the proliferation of vascular smooth muscle cells via regulating MEG3/miR-125a-5p/IRF1

Cell Adhesion & Migration, 2019
In this study, we investigated the role ofhistone deacetylase 4 (HDAC4) and MEG3/miR-125a-5p/interferonregulatoryfactor 1 (IRF1) on vascular smooth muscle cell (VSMCs)proliferation.
Xiangtao Zheng, Ziheng Wu, Ke Xu, Yihui Qiu, Xiang Su, Zhen Zhang, Mengtao Zhou   +6 more
doaj   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, Volume 159, Issue 11, Page 2633-2652, 1 December 2026.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source

The expression of HDAC4 in transfected SGC-7901 cells.

, 2014
HDAC4 expression was determined in SGC-7901 cells transfected with empty vector (NC) or HDAC4 (A) and (B). HDAC4 expression was determined in SGC-7901 cells transfected with siRNA oligos targeting HDAC4 (si-HDAC4) or scrambled siRNA (si-NC) by qRT-PCR ...
Sen Hong (572430), Yu-Yang Lin (572429), Lei Wang (6656), Jian-Tao Zhang (572428), Chun-Hua Yuan (270168), Chun-Yan Wang (358603), Ping-Wei Zhao (558412), Wen-Liang Zhang (572427), Chen-Yao Li (572431), Zhen-Hua Kang (572426)   +9 more
core   +1 more source

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, Volume 46, Issue 6, Page 1477-1498, November 2026.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Investigation of differential HDAC4 methylation patterns in eating disorders [PDF]

Psychiatric Genetics, 2018
The objective of this study was to investigate the relationship between methylation patterns of the histone deacetylase 4 gene and eating disorders in a site previously associated with anorexia nervosa (AN). Women with AN (N=28) or bulimia nervosa (BN) (N=19) were age-matched and sex-matched to controls (N=45).
Subha, Subramanian, Patricia R, Braun, Shizhong, Han, James B, Potash   +3 more
openaire   +2 more sources

HDAC4 is a target of miR-29a.

, 2015
(A) Predicted putative (upper) and mutated (lower, shown in red) binding sequence in the 3’UTR of HDAC4 mRNA, displayed from 5’ to 3’. (B) The relative luciferase activity.
Yingliang Ou (803807), Jinrui Ou (455887), Huiling Wang (169598), Caixia Li (522464), Zhixiang Jian (455888)   +4 more
core   +1 more source

Hdac4 Modulates Bone Biology Via Regulation Of Mineralization And Ferroptosis

International Dental Journal
Aim or purpose: To investigate the role of HDAC4 in bone homeostasis and regeneration, focusing on its epigenetic regulation of mesenchymal stem cells (MSCs) mineralization and osteoblasts ferroptosis.
Xiaofeng Wang, Xudong Wang, Shuai Wang
doaj   +1 more source

Identification of MEF2A, MEF2C, and MEF2D interactomes in basal and Fsk‐stimulated mouse MA‐10 Leydig cells

Andrology, Volume 14, Issue 8, Page 2401-2418, November 2026.
Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos, Marie‐Pier Scott‐Boyer, Arnaud Droit, Robert S. Viger, Jacques J. Tremblay   +4 more
wiley   +1 more source