Results 81 to 90 of about 14,188 (207)

Oxidation of HDAC4 by Nox4-derived H2O2 maintains tube formation by endothelial cells

Redox Biology, 2020
NADPH oxidases produce reactive oxygen species that differ in localization, type and concentration. Within the Nox family only Nox4 produces H2O2 which can directly oxidize cysteine residues. With this post-translational modification, activity, stability,
Tim Schader, Oliver Löwe, Christina Reschke, Pedro Malacarne, Fabian Hahner, Niklas Müller, Anna Gajos-Draus, Johannes Backs, Katrin Schröder   +8 more
doaj   +1 more source

RETRACTED: Compression regulates gene expression of chondrocytes through HDAC4 nuclear relocation via PP2A-dependent HDAC4 dephosphorylation

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2016
Biomechanics plays a critical role in the modulation of chondrocyte function. The mechanisms by which mechanical loading is transduced into intracellular signals that regulate chondrocyte gene expression remain largely unknown. Histone deacetylase 4 (HDAC4) is specifically expressed in chondrocytes.
Chongwei, Chen, Xiaochun, Wei, Shaowei, Wang, Qiang, Jiao, Yang, Zhang, Guoqing, Du, Xiaohu, Wang, Fangyuan, Wei, Jianzhong, Zhang, Lei, Wei   +9 more
openaire   +2 more sources

The presence of HDAC4 and HDAC5 in mouse myocardium.

, 2013
The myocytes were stained with anti-sarcomeric actinin (green), HDAC4 and HDAC5 proteins were stained with anti-HDAC4 and HDAC5 (red). Nuclei were stained with 4′6-diamidino-2-phenylindole (DAPI, blue). Images show an overlay of myocytes, HDAC4 and HDAC5
Shugang Zhuang (420017), Ting C. Zhao (102950), Jianfeng Du (420016), Ling X. Zhang (420018), Paul Liu (78766)   +4 more
core   +1 more source

Conditional deletion of HDAC4 from collagen type 2α1-expressing cells increases angiogenesis in vivo

Molecular Medicine, 2020
Background HDAC4 is a key regulator of chondrocyte hypertrophy and skeletal development, but it is not clear whether the increase in vascular invasion at growth plates is related to HDAC4 expression.
Lilan Gao, Shengchun Li, Xiaochun Wei, Guoqing Du, Dennis Wei, Lei Wei   +5 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, Volume 20, Issue 9, Page 2135-2162, September 2026.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

HDAC4 deacetylase associates with and represses the MEF2 transcription factor [PDF]

The EMBO Journal, 1999
The acetylation state of histones can influence transcription. Acetylation, carried out by acetyltransferases such as CBP/p300 and P/CAF, is commonly associated with transcriptional stimulation, whereas deacetylation, mediated by the three known human deacetylases HDAC1, 2 and 3, causes transcriptional repression. The known human deacetylases represent
E A, Miska, C, Karlsson, E, Langley, S J, Nielsen, J, Pines, T, Kouzarides   +5 more
openaire   +2 more sources

Hdac4 Modulates Cranial Neural Crest Mesenchymal Cells In Intramembranous Ossification

International Dental Journal
Aim or purpose: Congenital craniofacial developmental defects refer to congenital abnormalities in the bones or soft tissues of the head and face, accounting for one-third of all congenital defects.The specific pathogenic mechanisms involve transcription
Shuai Wang, Xudong Wang, Hao Sun
doaj   +1 more source

Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p

Cancer Management and Research, 2020
Jun Liu,1 Guang Feng,2 Zhengwei Li,3 Rui Li,1 Peng Xia1 1Department of Hand Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130000, People’s Republic of China; 2The Fourth Medical Center of PLA General Hospital, Beijing 100048 ...
Liu J, Feng G, Li Z, Li R, Xia P
doaj  

Metabolic Memory in Cardiovascular Disease: Encoding, Propagation, and Therapeutic Targeting

Advanced Science, Volume 13, Issue 54, 28 September 2026.
Cardiovascular risk often persists after metabolic abnormalities are corrected. This conceptual Review frames such persistence as metabolic memory, encoded through a narrowing therapeutic window from reversible marks to irreversible damage, with continuous input from peripheral organs.
Cheng Cheng, Minghui Tang, Zhaobo Zhang, Ruoyi Qu, Jianfei Pei, Tian Liu, Siyao Qu, Shilong You, Shenshen Cui, Wenke Wang, Rui Zhao, Yingxian Sun, Naijin Zhang   +12 more
wiley   +1 more source

Crosstalk of HDAC4, PP1, and GSDMD in controlling pyroptosis

Cell Death & Disease
AbstractGasdermin D (GSDMD) functions as a pivotal executor of pyroptosis, eliciting cytokine secretion following cleavage by inflammatory caspases. However, the role of posttranslational modifications (PTMs) in GSDMD-mediated pyroptosis remains largely unexplored.
Weilv Xu, Qiao Jin, Xinyue Li, Danyue Li, Xinyu Fu, Nan Chen, Qian Lv, Yuhua Shi, Suhui He, Lu Dong, Yang Yang, Yuqi Yan, Fushan Shi   +12 more
openaire   +3 more sources