Results 91 to 100 of about 14,188 (207)

HDAC4 gene silencing alleviates epilepsy by inhibition of GABA in a rat model

, 2019
Yinian Zhang,1,2,* Hua-Teng Dong,3,* Lei Duan,1,2 Liang Niu,1,2 Guo-Qiang Yuan,1,2 Jun-Qiang Dai,1,2 Bo-Ru Hou,1,2 Ya-Wen Pan1,2 1Department of Neurosurgery and Laboratory of Neurosurgery, Lanzhou University Second Hospital, Lanzhou 730030, People’
Duan L, Dong HT, Niu L, Yuan GQ, Dai JQ, Zhang YN, Hou BR, Pan YW   +7 more
core  

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, Volume 293, Issue 18, Page 5481-5513, September 2026.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

Adaptation of White Adipocytes to Cooler Temperatures: Impacts on Energy Metabolism and Protein Acetylation

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Cultured white adipocytes exposed to 31°C undergo cell‐autonomous metabolic adaptation characterized by enhanced mitochondrial function and widespread remodeling of the mitochondrial acetylome. Acetyl‐proteomic and metabolomic profiling identified mitochondria‐associated proteins, including SHMT2 and PCCA, whose acetylation changes were linked to ...
Hiroyuki Mori, Hadla Hariri, William Moe, Sophia Durham, Yuridia Guzman, Emma Paulsson, Rachel C. Simmermon, Parth B. Bhanderi, Sydney K. Peterson, Mia J. Dickson, Charles R. Evans, Ormond A. MacDougald   +11 more
wiley   +1 more source

OA impairs the HDAC4 nuclear import induced by CTS.

, 2016
(A) Fluorescence microscope showed GFP-HDAC4 was mainly located in the nucleus in cells subjected to CTS only (a-c), and mainly in the cytoplasm in cells subjected to CTS with OA (d-f).
Zhi Lv (321968), Xiaojuan Sun (151034), Yang Zhang (30734), Yongping Li (331330), Shaowei Wang (490684), Lei Wei (18880), Qiang Jiao (2697121), Chongwei Chen (2697124), Xiaochun Wei (413327), Xiaohu Wang (95084)   +9 more
core   +1 more source

HDAC4: studying the pro-oncogenic role in human immortalized fibroblasts [PDF]

, 2016
In vitro transformation of primary human fibroblasts has been commonly used to understand the specific steps required to generate neoplastic cells following the ordered introduction of cellular and viral oncogenes and/or the down-modulation of tumor ...
GAGLIOSTRO, Enrico
core   +1 more source

Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis

BMC Biology
Background Dysregulation of nucleocytoplasmic shuttling of histone deacetylase 4 (HDAC4) is associated with several neurodevelopmental and neurodegenerative disorders.
Wei Jun Tan, Hannah R. Hawley, Sarah J. Wilson, Helen L. Fitzsimons   +3 more
doaj   +1 more source

Overexpression of miR-29a decreased HDAC4 expression in primary HSCs.

, 2015
Treatment with a miR-29a mimic and HDAC4 RNAi significantly deceased HDAC4 expression in the HSCs of WT mice. Data are expressed as the mean ± SE of four independent experiments. *indicates a p < 0.05 between the groups.
Mao-Meng Tiao (446593), Ying-Hsien Huang (446595), Jiin-Haur Chuang (171983), Li-Tung Huang (280487), Kuang-Che Kuo (787054), Feng-Sheng Wang (787055), Ya-Ling Yang (664304)   +6 more
core   +1 more source

Effects of electrical stimulation on the CIHH-induced reduction of HDAC4 and nuclear HDAC4 protein.

, 2016
Gastrocnemius muscles were isolated from the lower limb of three groups of rats at 2 weeks (A) and 4 weeks (B). Analyses of the expression of HDAC4 and nuclear HDAC4 proteins were performed by Western blotting.
Xiao-Tong Wang (2588068), Shi-Yuan Huang (551009), Xian-Xun Jiang (2588074), Cui-Cui Zhao (2097124), Jiang-Qiong Ke (2588071), Jie Shen (31533), Lu-Lu Pan (2588065)   +6 more
core   +1 more source

Class IIa HDAC Downregulation Contributes to Surgery-Induced Cognitive Impairment Through HMGB1-Mediated Inflammatory Response in the Hippocampi of Aged Mice

Journal of Inflammation Research, 2021
Chen-miao Huang,1,2 Jia-jing Cai,1,2 Shao-wu Jin,1,2 Qi-cheng Lin,1,2 Qian-juan Fang,1,2 Ke Nan,1,2 Yuan Han,1,2 Wen-wei Ge,1,2 Yu Liu,1,2 Yuan-xiang Tao,1,3 Hong Cao,1,2 Jun Li1,2 1Department of Anesthesiology and Perioperative Medicine, The Second ...
Huang C, Cai J, Jin S, Lin Q, Fang Q, Nan K, Han Y, Ge W, Liu Y, Tao Y, Cao H, Li J   +11 more
doaj  

Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p [Retraction]

Cancer Management and Research, 2023
Liu J, Feng G, Li Z, Li R, Xia P. Cancer Manag Res. 2020;12:10199–10210. We, the Editors and Publisher of Cancer Management and Research, have retracted the following article. Since publication, concerns have been raised about the integrity of the
Liu J, Feng G, Li Z, Li R, Xia P
doaj