Results 71 to 80 of about 14,188 (207)

Novel role and regulation of HDAC4 in cocaine‐related behaviors [PDF]

Addiction Biology, 2017
AbstractEpigenetic mechanisms have been proposed to contribute to persistent aspects of addiction‐related behaviors. One family of epigenetic molecules that may regulate maladaptive behavioral changes produced by cocaine use are the histone deacetylases (HDACs)—key regulators of chromatin and gene expression.
Rachel D. Penrod, Maria B. Carreira, Makoto Taniguchi, Jaswinder Kumar, Stephanie A. Maddox, Christopher W. Cowan   +5 more
openaire   +2 more sources

Domain organisation of human and Drosophila HDAC4 proteins.

, 2013
A. One isoform of each protein is shown (Human HDAC4 GenBank accession NP_006028, 1084 amino acids; Drosophila HDAC4, isoform D, GenBank accession NP_572868, 1252 amino acids).
Silvia Schwartz (162929), Maxwell J. Scott (192572), Fiona M. Given (494601), Helen L. Fitzsimons (192571)   +3 more
core   +1 more source

HDAC4 is localised to the cytoplasm in the P3 brain.

, 2013
(A) Western blot showing that HDAC4 is localised exclusively to the cytoplasm and absent in Hdac4KO brains. (B) Confocal images demonstrating that HDAC4 is localised to the cytoplasm. Scale bar = 25 μm.
Christian Landles (250060), Gillian P. Bates (135712), Vahri Beaumont (112469), Tamara Seredenina (213942), Georgina F. Osborne (488792), Michal Mielcarek (195209), Ruth Luthi-Carter (18698), Jeffrey C. Silva (488794), Matthew P. Stokes (488791), Sophie A. Franklin (195218), Linda Inuabasi (488793)   +10 more
core   +1 more source

A role for the histone deacetylase HDAC4 in the life-cycle of HIV-1-based vectors

Virology Journal, 2010
HIV-1 integration is mediated by the HIV-1 integrase protein, which joins 3'-ends of viral DNA to host cell DNA. To complete the integration process, HIV-1 DNA has to be joined to host cell DNA also at the 5'-ends. This process is called post-integration
Kao Gary D, Yeung Jennifer, Smith Johanna A, Daniel René   +3 more
doaj   +1 more source

Histone deacetylase inhibitors as venetoclax‐sensitising partners in acute myeloid leukaemia: Mechanisms, pharmacology and translational perspectives

British Journal of Pharmacology, Volume 183, Issue 21, Page 6261-6290, November 2026.
Abstract Venetoclax combined with hypomethylating agents has improved treatment for older or unfit patients with acute myeloid leukaemia (AML), but resistance and relapse remain common. This review analyses the rationale for combining venetoclax with inhibitors of histone deacetylase (HDAC).
Jaebok Lee, Marc Diederich
wiley   +1 more source

HDAC4 regulates skeletal muscle regeneration via soluble factors [PDF]

, 2018
Skeletal muscle possesses a high ability to regenerate after an insult or in pathological conditions, relying on satellite cells, the skeletal muscle stem cells.
Sergio Adamo, Nicoletta Marroncelli, Adamo, Sergio, Viviana Moresi, Alessandra Renzini, Marroncelli, Nicoletta, Renzini, Alessandra, Chiara Noviello, Moresi, Viviana, Noviello, Chiara   +9 more
core   +1 more source

Short‐Chain Fatty Acids: Microbial Metabolites Driving Gut‐Eye Axis Signaling

Comprehensive Physiology, Volume 16, Issue 5, October 2026.
Short‐chain fatty acids generated by gut microbial fermentation link diet to ocular physiology via the gut–eye axis. Through systemic distribution, these metabolites regulate GPCR signaling, epigenetic pathways, inflammation, and angiogenesis, shaping retinal homeostasis and highlighting therapeutic potential in ocular vascular and inflammatory ...
Aleah J. Brokemond, Ronny Amamoo, Fapianey J. Alexandre, Sewedo B. Ajisegiri, Menaka C. Thounaojam, Pamela M. Martin, Ravirajsinh N. Jadeja   +6 more
wiley   +1 more source

Histone deacetylase 4 protects from denervation and skeletal muscle atrophy in a murine model of amyotrophic lateral sclerosisResearch in context

EBioMedicine, 2019
Background: Histone deacetylase 4 (HDAC4) has been proposed as a target for Amyotrophic Lateral Sclerosis (ALS) because it mediates nerve-skeletal muscle interaction and since its expression in skeletal muscle correlates with the severity of the disease.
Eva Pigna, Elena Simonazzi, Krizia Sanna, Krzysztof Marian Bernadzki, Tomek Proszynski, Constantin Heil, Daniela Palacios, Sergio Adamo, Viviana Moresi   +8 more
doaj   +1 more source

Novel Flavonoid Senotherapeutics Identified by Phenotypic Drug Discovery Reduce Senescence and Improve Multiple Markers of Healthspan

Aging Cell, Volume 25, Issue 10, October 2026.
Phenotypic screening and SAR‐guided drug design identified two flavonoid‐derived senolytics, SR29384 and SR31133, which selectively killed different types of senescent cells more efficiently and with greater selectivity than fisetin in culture. In aged and progeroid mice, these fisetin analogs reduced tissue senescence and improved physical function ...
Lei Justan Zhang, Rahagir Salekeen, Carolina Soto‐Palma, Qiuming Wu, Yuanjun He, Osama Elsallabi, Bilel Bdiri, Brian Hughes, Allancer Nunes, Wandi Xu, Borui Zhang, Abdalla Mohamed, Sara J. McGowan, Luise Angelini, Ryan O'Kelly, Theodore M. Kamenecka, Laura J. Niedernhofer, Paul D. Robbins   +17 more
wiley   +1 more source

Stress-induced epigenetic transcriptional memory of acetylcholinesterase by HDAC4 [PDF]

Proceedings of the National Academy of Sciences, 2012
Stress induces long-lasting changes in neuronal gene expression and cholinergic neurotransmission, but the underlying mechanism(s) are incompletely understood. Here, we report that chromatin structure and histone modifications are causally involved in this transcriptional memory. Specifically, the AChE gene encoding the acetylcholine-hydrolyzing enzyme
Badi Sri, Sailaja, Dorit, Cohen-Carmon, Gabriel, Zimmerman, Hermona, Soreq, Eran, Meshorer   +4 more
openaire   +2 more sources